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American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.

    J. Ruben,1 G. Garcia-Romo,1 E. Breman,1 S. van der Kooij,1 A. Redeker,2 R. Arens,2 C. van Kooten.1

    1Nephrology, Leiden University Medical Centre, Leiden, Netherlands; 2Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.

    Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
  • 2016 American Transplant Congress

    Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.

    J. Leigh,1 P. Shao,1 M. Saha,1 I. Lobb,1 A. Pasch,5 H. van Goor,4 M. Feelisch,2 R. Wang,3 A. Sener.1

    1Western University, London, Canada; 2University of Southhampton, Southhampton, United Kingdom; 3Lakehead University, Thunder Bay, Canada; 4University of Gronigen, Groningen, Netherlands; 5University Hospital Bern, Bern, Switzerland.

    Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…
  • 2016 American Transplant Congress

    Circulating miR-215, miR-let-7c miR-154, miR-193a, NR_036506.1 and NR_027669.1 as Biomarkers Predict Fungal Infection in Post-Transplanted Recipients.

    A. Yang, Z. Guo, W. Ju, C. Zhang, Z. Li, X. Yuan, Q. Zhao, H. Ye, Y. Liao, X. Zhu, X. He.

    Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Aims: The incidence of fungal infection in post-transplanted patients is 13%-17%, which seriously effecting perioperative survival and increasing their economic burden. We wanted to find…
  • 2016 American Transplant Congress

    The Epidemiology of Clostridium difficile Infection in a National Kidney Transplant Center.

    C. Kennedy,1 C. Waldron,1 M. Scally,2 K. Burns,2 C. Magee,1 F. Fitzpatrick.2

    1Department of Nephrology, Beaumont Hospital, Dublin, Ireland; 2Department of Microbiology, Beaumont Hospital, Dublin, Ireland.

    BackgroundKidney transplant recipients (KTRs) are at increased risk of Clostridium difficile infection (CDI). We aimed to retrospectively describe the epidemiology of CDI in a national…
  • 2016 American Transplant Congress

    Significance of Preservation Fluid Cultures in Solid Organ Transplantation.

    H. Nam, N. Perni, K. Galen, M. Campara, R. Roca-Garcia, V. Yeldandi.

    University of Illinois at Chicago, Chicago.

    Introduction. The study aim was to determine microbiological characteristics of preservation fluid (PF) cultures in solid organ transplant (SOT) patients and to evaluate their impact…
  • 2016 American Transplant Congress

    Two-Year Safety Results from the Phase 3b Switching Study of Kidney Transplant Patients with Tremor to LCP-Tacro (STRATO) Study.

    S. Steinberg,1 R. Gedaly,2 L. Chan,3 A. Langone.4

    1California Institute of Renal Research, San Diego; 2University of Kentucky Medical Center, Lexington; 3University of Colorado, Aurora; 4Vanderbilt University Medical Center, Nashville.

    Tremor is a common side effect of tacrolimus (tac) correlated with peak-dose drug concentration. Envarsus XR®, a novel, once-daily, extended-release formulation of tac, has a…
  • 2016 American Transplant Congress

    Low Pretransplant BMI/Weight and Changes in Posttransplant T Cell Exhaustion Levels Are Associated with Viremia/Viral Infection in Pediatric Kidney Transplantation in the First Post-Transplant Year – A Report from the IMPACT Study Consortium.

    R. Ettenger,1 H. Chin,2 P. Grimm,3 K. Kesler,2 E. Reed,4 M. Sarwal,5 B. Warshaw,6 E. Tsai,1 A. Kirk.7

    1Pediatrics, UCLA, LA, CA; 2Rho, Chappel Hill, NC; 3Pediatrics, Stanford Univ, Palo Alto, CA; 4Pathology, UCLA, LA, CA; 5Surgery, UCSF School of Medicien, SF, CA; 6Pediatric Nephrolgoy, Children's Healthcare of Atlanta, Atlanta, GA; 7Surgery, Duke University, Durham, NC.

    Viral consequences of immunosuppression (IS) in pediatric(ped)kidney(kid)transplantation(Tx)patients(pts) are not fully known. We prospectively examined the immunologic and infectious (inf) history of 106 ped Tx pts…
  • 2016 American Transplant Congress

    Deceased Non-A2 Donor ABO-Incompatible Liver Transplantation – Promising Results with Anti-A/B Antibody Reduction Both Pre- and Post-Transplant.

    U. Dahlgren,1 G. Herlenius,1 J. Mölne,2 L. Rydberg,3 O. Samuelsson,4 W. Bennet.1

    1Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden; 2Department of Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden; 3Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; 4Department of Nephrology, Sahlgrenska University Hospital, Gothenburg, Sweden.

    IntroductionOne way to expand the donor pool for patients with acute liver failure could be to use deceased donor (DD) ABO-incompatible (ABOi) liver grafts. However,…
  • 2016 American Transplant Congress

    When Liver Transplants and Procurement Occur at One Location – A National Study of Graft Survivals.

    J. Ortiz,1 N. Koizumi,2 C. Kwon,2 Y. Zhang,2 C. Ortiz.3

    1University of Toledo, Toledo, OH; 2George Mason University, Fairfax, VA; 3Bucknell University, Lewisburg, PA.

    Organ procurement and placement processes entail complex scheduling, logistics and other administrative challenges, especially when organs travel outside the procuring Organ Procurement Organization (OPO) area.…
  • 2016 American Transplant Congress

    Portal Venous Flow Volume Measurements May Aid Intraoperative Management of Large Portosystemic Shunts During Pediatric Liver Transplantation.

    T. Pshak,1 J. Roach,2 F. Karrer,2 M. Wachs.2

    1Transplant Surgery, Univ of Colorado, Aurora, CO; 2Transplant Surgery, Children's Hospital Colorado, Aurora, CO.

    PURPOSE: In pediatric patients undergoing liver transplantation, portal hypoperfusion can result in irreversible portal vein thrombosis and early graft loss. Intraoperative hepatic hemodynamic studies have…
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