ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Relationship Between Dialisys Duration and Prevalence of Cardiovascular Diseases in Kidney Transplantation Recipients.

    K. Unagami,1 M. Okumi,2 T. Hirai,2 Y. Okabe,3 K. Masutani,4 T. Shimizu,2 K. Omoto,2 M. Inui,2 H. Ishida,2 T. Kitazono,4 K. Nitta,1 K. Tanabe,2 The Japan Academic Consortium of Kidney Transplantation (JACK).

    1Nephrology, Tokyo Women's Medical University, Tokyo, Japan; 2Urology, Tokyo Women's Medical University, Tokyo, Japan; 3Surgery, Kyushu University, Fukuoka, Japan; 4Medicine and Clinical Science, Kyushu University, Fukuoka, Japan.

    Background: Among kidney transplantation (KTx) recipients, the prevalence of Cardiovascular disease (CVD) is high. However, to our knowledge, the relationship between the prevalence of CVD…
  • 2016 American Transplant Congress

    Quantiferon-CMV Test, CMV-Specific ELISPOT and CMV-Dextramer Assays in Assessing the Risk of CMV Infection in Seropositive Kidney Transplant Recipients.

    H. Lee,1 K. Park,2 J. Ryu,2 J. Yu,3 B. Chung,3 C. Yang,3 E.-J. Oh.1

    1Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea; 2Department of Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Korea; 3Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.

    Human cytomegalovirus (CMV) infection is one of the primary opportunistic pathogens and is a leading cause of morbidity and mortality in kidney transplant recipients. Assessing…
  • 2016 American Transplant Congress

    Predictors of Post Transplant Lymphoprolipherative Disorder Among Adult Kidney Transplant Recipients.

    M. Mohamed, S. Parajuli, B. Muth, A. Djamali, B. Astor.

    Internal Medicine, University of Wisconsin School of Medicine, Madison, WI.

    Objective: Identifying predictors of Post Transplant Lymphoprolipherative Disorder (PTLD); early (0 - 3 years) and late in kidney transplantation.Methodology: Single center longitudinal study among kidney…
  • 2016 American Transplant Congress

    C1q Donor Specific Antibody Associates with Post Transplant Biopsy Findings in Highly Sensitized Kidney Transplant Recipients.

    S. Kuppachi,1 D. Holanda,2 S. Gallegos,3 E. Field.3,4

    1Nephrology, University of Iowa Hospitals and Clinics, Iowa City, IA; 2Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA; 3Iowa Regional Histocompatibility and Immunogenetics Laboratory, Veteran Affairs Medical Center, Iowa City, IA; 4Immunology, University of Iowa Hospitals and Clinics, Iowa City, IA.

    We performed monitoring of conventional donor specific antibodies (DSA) and C1q binding DSA (C1q DSA) to correlate levels with pathology findings in protocol kidney biopsies…
  • 2016 American Transplant Congress

    The Effect of Tocilizmab Treatment (TCZ-Rx) on Total IgG and Anti-CMV-IgG Levels in HLA-Sensitized (HS) Kidney Transplant Patients.

    B.-H. Shin, S. Ge, J. Choi, J. Kahwaji, A. Vo, A. Petrosyan, S. Jordan, M. Toyoda.

    Transplant Immunology Lab, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: TCZ has anti-B cell and anti-inflammatory properties. We have reported its successful use for pre-transplant (Tx) desensitization (DES) and treatment of ABMR. We also…
  • 2016 American Transplant Congress

    Inflammatory Conditions Switch the Effect of MSC on B Cells from Pro-Tolerogenic to Anti-Proliferative.

    M. Franquesa,1,2 F. Luk,1 S. Korevaar,1 L. Boon,3 F. Borras,2 M. Betjes,1 C. Baan,1 M. Hoogduijn.1

    1Transplantation and Nephrology Lab, Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2IVECAT, Nephrology Department, IGTP, Badalona, Spain; 3Bioceros, Utrecht, Netherlands.

    The immunomodulatory capacity of mesenchymal stem cells (MSC) makes them a promising therapeutic tool in transplantation. MSC are recently gaining interest for their immunomodulatory effects…
  • 2016 American Transplant Congress

    High Resolution Detection of Human Pancreatic Islet Damage During and After Isolation Procedure Using MicroRNAs.

    S. Prathab Balaji,1 M. Kanak,2 G. Yoshimatsu,1 C. Chang,1 M. Levy,2 M. Lawrence,1 P. Kim,3 N. Onaca,3 B. Naziruddin.3

    1Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; 2Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX.

    Background: Pancreatic islets are subjected to stresses throughout isolation procedures that account for considerable variation in quality and yield. Multiparameter methods are needed to monitor…
  • 2016 American Transplant Congress

    Calcineurin Inhibitor (CNI) Nephrotoxicity Is Mediated by Defective Amp-Activated Protein Kinase (AMPK) Activation.

    A. Zmijewska, J. Chen, J. Zmijewski, R. Mannon.

    Medicine, UAB, Birmingham, AL.

    Background: CNIs are potent immunosuppressant therapies, but associated with nephrotoxicity manifested by interstitial fibrosis and progressive graft dysfunction. AMPK is a major sensor and regulator…
  • 2016 American Transplant Congress

    Three-Year Outcome After HSCT with Subsequent KT from the Same Haploidentical Donor without Immunosuppression.

    C. Schwarz,1 A. Lawitschka,2 G. Böhmig,3 E. Dauber,4 H. Greinix,5 N. Kozakowski,6 F. Mühlbacher,1 G. Berlakovich,1 T. Wekerle.7

    1Dept. of Surgery, Div. of Transplantation, Medeical University of Vienna, Vienna, Austria; 2St. Anna Children's Hospital, Vienna, Austria; 3Dept. of Internal Medicine, Division of Nephrology, Medical University of Vienna, Vienna, Austria; 4Dept. of Transfusion Medicine, Medical University of Vienna, Vienna, Austria; 5Dept of Internal Medicine, Div of Hematology, Medical University of Graz, Graz, Austria; 6Dept. of Clinical Pathology, Medical University of Vienna, Vienna, Austria; 7Section of Transplantation Immunology, Dept. of Surgery, Medical University of Vienna, Vienna, Austria.

    Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to donor-specific tolerance. Patients reported in the literature that underwent kidney transplantation (KT) after a previous HSCT…
  • 2016 American Transplant Congress

    Assessing Vaccination Status in Transplant Candidates and Recipients: Current Status and Challenges to Successful Implementation.

    H. Leung, K. Cameron, B. Ho, M. Ison.

    Northwestern University Feinberg School of Medicine, Chicago, IL.

    Background: Vaccines are safety and efficacy of vaccines in transplant candidates and recipients. Several studies have demonstrated significant underutilization of vaccines which increases the risk…
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