Relationship Between Dialisys Duration and Prevalence of Cardiovascular Diseases in Kidney Transplantation Recipients.

K. Unagami,¹ M. Okumi,² T. Hirai,² Y. Okabe,³ K. Masutani,⁴ T. Shimizu,² K. Omoto,² M. Inui,² H. Ishida,² T. Kitazono,⁴ K. Nitta,¹ K. Tanabe,² The Japan Academic Consortium of Kidney Transplantation (JACK).

¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan
²Urology, Tokyo Women's Medical University, Tokyo, Japan
³Surgery, Kyushu University, Fukuoka, Japan
⁴Medicine and Clinical Science, Kyushu University, Fukuoka, Japan.

Meeting: 2016 American Transplant Congress

Abstract number: C266

Keywords: Graft survival, Kidney transplantation

Topic:

Session Information

Session Name: Poster Session C: Poster Session 1: Kidney Complications-Other

Date: Monday, June 13, 2016

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Background: Among kidney transplantation (KTx) recipients, the prevalence of Cardiovascular disease (CVD) is high. However, to our knowledge, the relationship between the prevalence of CVD in KTx recipients and the hemodialysis duration before KTx has not yet been evaluated. Moreover, although we previously reported that there was no significant relationship between patient or graft survival and dialysis duration, we did not evaluate the relationship with prevalence of CVD. In this study, we evaluated the influence of dialysis duration on the outcome of KTx.

Methods: Between 2000 and 2013, we performed 1050 KTx from living related donors. We divided the patients into three groups according to dialysis duration: group A: ≤16 months (N=350), group B: 17-47 months (N=351), group C: ≥48 months (N=349).

Results: Data were statistically analyzed using the log-rank test for trend. The mean duration of dialysis across all groups was 28 months (7, 28, 86 months in groups A, B, and C, respectively; p<0.001). Seventy-four patients in Group A underwent preemptive KTx. Age of recipients, follow-up period, type of related donors, and kinds of calcineurin inhibitors administered for immunosuppresion were significantly different (both p <0.001). The prevalence of CVD increased significantly with the increase in hemodialysis duration (p=0.026) . However, no significant differences were observed in patient or graft survival among the three groups (p=0.942, p=0.581, respectively). Serum creatinine levels, estimated GFR levels, and biopsy proven rejection rates after KTx showed no significant differences in both groups.

Conclusions: Despite no significant differences in patient or graft survival, the prevalence of CVD significantly increased with the increase in hemodialysis duration.

CITATION INFORMATION: Unagami K, Okumi M, Hirai T, Okabe Y, Masutani K, Shimizu T, Omoto K, Inui M, Ishida H, Kitazono T, Nitta K, Tanabe K, The Japan Academic Consortium of Kidney Transplantation (JACK) Relationship Between Dialisys Duration and Prevalence of Cardiovascular Diseases in Kidney Transplantation Recipients. Am J Transplant. 2016;16 (suppl 3).

To cite this abstract in AMA style:

Unagami K, Okumi M, Hirai T, Okabe Y, Masutani K, Shimizu T, Omoto K, Inui M, Ishida H, Kitazono T, Nitta K, Tanabe K. Relationship Between Dialisys Duration and Prevalence of Cardiovascular Diseases in Kidney Transplantation Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/relationship-between-dialisys-duration-and-prevalence-of-cardiovascular-diseases-in-kidney-transplantation-recipients/. Accessed July 28, 2021.

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