Am J Transplant, Volume 16, Suppl 3 Archives - Page 39 of 180 - ATC Abstracts

2016 American Transplant Congress
Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.
J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
2016 American Transplant Congress
A Novel, Non-Viral mRNA Delivery System for Targeted Protein Translation in Human Islets.
J. Oberholzer,^1,2 D. Gutierrez,^1,2 E. Marchese,¹ M. Nourmohammadzadeh,^1,2 Y. Wang.^1,2
¹Department of Surgery, University of Illinois at Chicago, Chicago, IL; ²Department of Bioengineering, University of Illinois at Chicago, Chicago, IL.
Background: We propose using an innovative technology that utilizes gold nanoparticles (AuNPs) as a non-viral method of delivery. Our laboratory was one of the first…
2016 American Transplant Congress
NKG2A-Expressing Natural Killer Cells Dominate the Response to Latent Epstein-Barr Virus Infection.
O. Hatton,¹ D. Strauss-Albee,² S. Krams,¹ C. Blish,² O. Martinez.¹
¹Surgery, Stanford University School of Medicine, Stanford, CA; ²Medicine, Stanford Univerity School of Medicine, Stanford, CA.
Introduction: EBV infection elicits a robust host immune response in healthy, immunocompetant individuals. EBV immunity is essential for preventing EBV-associated lymphomas in transplant recipients, including…
2016 American Transplant Congress
Ex Vivo Expansion and Functional Characterization of Human Alloantigen-Specific Regulatory T Cells.
J. Mathew,¹ S. McEwen,¹ I. Konieczna,¹ X. Huang,¹ J. He,¹ R. Kornbluth,² J. Miller,¹ L. Gallon,¹ J. Leventhal.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Multimeric Biotherapeutics, Inc, La Jolla, CA.
Purpose: Regulatory T cells (Tregs) have been associated with clinical transplant tolerance and they have been shown to prolong graft survival in animal models without…
2016 American Transplant Congress
Vaccination Compliance in Listed Kidney Transplant Candidates: A Retrospective Chart Review.
I. Tawhari,¹ C. Staffeld-Coit,² J. Garcia-Diaz.¹
¹Infectious Disease, Ochsner Health System, New Orleans, LA; ²Nephrology, Ochsner Health System, New Orleans, LA.
Background: Infections in solid organ transplant recipients, some of which are vaccine preventable, may result in excessive morbidity and mortality. Immunosuppressive agents increase the risk…
2016 American Transplant Congress
Innate Immune Signaling During Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² C. Lassman,¹ R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,¹ E. Reed.¹
¹Pathology and Lab Medicine, University of California-Los Angeles, Los Angeles, CA; ²Surgery, University of California-Los Angeles, Los Angeles, CA.
Background: Orthotopic liver transplantation (OLT) success is hampered by cellular damage elicited by ischemia-reperfusion injury (IRI) which lowers allograft survival. Research using murine models has…
2016 American Transplant Congress
Successful Prophylactic Use of Eculizumab in aHUS Kidney Transplant Patients: A Report of 9 Cases.
A. Kumar,¹ Z. Stewart,³ A. Reed,³ D. Orozco,² R. Smith,^1,2 C. Nester,^1,2 C. Thomas.^1,2
¹Internal Medicine, Univ of Iowa, Iowa City; ²Pediatrics, Univ of Iowa, Iowa City; ³Surgery, Univ of Iowa, Iowa City.
AHUS is a thrombotic microangiopathy (TMA) triggered by alternate complement pathway (AP) dysregulation. In 60% of patients, a pathogenic variant can be identified in one…
2016 American Transplant Congress
Should HLA DR and DQ Eplet Mismatching Replace Traditional DR and DQ Mismatching for Deceased Donor Offers in Pediatric Renal Transplantation?
C. Bryan, V. Chadha, B. Warady.
Midwest Transplant Network, Kansas City, KS; Nephrology, Childrens Mercy Hospital, Kansas City, MO; Nephrology, Childrens Mercy Hospital, Kansas City, MO.
Introduction. It is now appreciated that greater HLA DR mismatching of the first pediatric kidney transplantation is associated with higher degrees of sensitization, lower rates…
2016 American Transplant Congress
Influence of Donor and Recipient CYP3A4, CYP3A5 and ABCB1 Genotypes on Outcomes in Liver Transplants.
M. Debette-Gratien,¹ J. Woillard,² N. Picard,² M. Sebbagh,⁴ D. Sautereau,⁵ V. Loustaud-Ratti,¹ D. Samuel,³ P. Marquet.²
¹Hepatology, INSERM UMR 850, Univ Limoges, CHU Limoges, Limoges, France; ²Pharmacology and Toxicology, INSERM UMR 850, Univ Limoges, CHU Limoges, Limoges, France; ³Hepatology, INSERM U785, Centre hépatobiliaire, Villejuif, France; ⁴Hepatology, Centre Hépatobiliaire, Villejuif, France; ⁵Hepatology, CHU Limoges, Limoges, France.
Liver transplantation is a life-saving technique for patients with end-stage liver disease. Pharmacogenetics is promising to explain a part of variability of calcineurin inhibitors efficacy…
2016 American Transplant Congress
Optimal Integration of Kidney Exchange Programs with Antibody Reduction Therapy to Increase Successful Transplant in Difficult to Match Recipients.
K. Melancon,¹ N. Koizumi,² M. Gentili,³ C. Callender.⁴
¹Surgery, George Washington University Hospital, Washington, DC; ²Public Policy, George Mason Univ, Arlington, VA; ³Operations Research, University of Louisville, Louisville, KY; ⁴Surgery, Howard University Hospital, Washington, DC.
Kidney paired donation (KPD) allows incompatible pairs to exchange kidneys with other incompatible pairs. However, evidence suggests there stills exist barriers to KPD utilization, especially…