ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Analysis of FSGS (Focal Segmental Glomerulosclerosis) Recurrence After Renal Transplantation.

    J. Mansur, G. Basso, M. Cristelli, G. Mata, T. Sandes-Freitas, G. Kirsztajn, H. Tedesco-Silva, J. Medina-Pestana.

    Nephrology-Division, Hospital do Rim - UNIFESP, São Paulo, Brazil.

    Purpose: To describe clinical-laboratorial profile and outcome of patients diagnosed with recurrent FSGS submitted to plasmapheresis.Methods: Retrospective single-center cohort study including all patients with recurrent…
  • 2016 American Transplant Congress

    Does DCD Donor Time-to-Death After Withdrawal of Support Affect Recipient Outcomes? Implications of Time-to-Death at a High-Volume Center in the United States.

    J. Scalea, L. Fernandez, A. D'Alessandro, M. Anderson, D. Foley, J. Mezrich.

    Surgery, University of Wisconsin, Madison, WI.

    Introduction: Donation after circulatory death (DCD) kidneys represent 15% of the deceased donor kidneys transplanted in the United States. A majority of transplant centers will…
  • 2016 American Transplant Congress

    Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.

    C. Lefaucheur,1 L. Hidalgo,2 J. Reeve,2 D. Viglietti,1 C. Gosset,1 O. Aubert,3 C. Ulloa,3 C. Legendre,3 D. Glotz,1 P. Halloran,2 A. Loupy.3

    1Saint-Louis Hospital, Paris, France; 2University of Alberta, Edmonton, Canada; 3Necker Hospital, Paris, France.

    Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…
  • 2016 American Transplant Congress

    Potential Kidney Donors with Asymptomatic Micorsocpic Hematuria: Histopathological Findings & Outcomes.

    E. Hassan,1,2 H. Aleid,1 T. Zulfiquar,1 I. Ibrahim,1,3 H. Almana.4

    1Department of Kidney & Pancreas Transplantation, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; 2Department of Nephrology, Fayoum University, Fayoum, Egypt; 3Department of Nephrology, Cairo University, Cairo, Egypt; 4Department of Anatomic Pathology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

    Background: Microscopic hematuria is not uncommon in potential kidney donors. After excluding urological causes, most of these donors require kidney biopsy to exclude glomerular lesions.…
  • 2016 American Transplant Congress

    mRNA Expression of BAFF and APRIL Receptors Increases in Acute Rejection in Kidney Transplant Recipients.

    M. Minz,1 R. Dhital,1 R. Minz,2 A. Sharma,1 R. Nada,3 S. Singh,1 D. Kenwar.1

    1Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 2Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 3Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

    Introduction:BAFF and APRIL are known survival and growth of B- cells.BAFF and APRIL share two receptors i-TACI and ii- BCMA. Additionally, BAFF has strong affinity…
  • 2016 American Transplant Congress

    Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.

    R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.

    Mayo Clinic, Phoenix, AZ.

    BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…
  • 2016 American Transplant Congress

    Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.

    A. Sánchez-Escuredo,1 A. Sagasta,2 F. Diekmann,1 I. Revuelta,1 L. Rodas,1 D. Paredes,3 M. Musquera,4 N. Esforzado,1 M. Ricart,1 F. Cofan,1 V. Torregrosa,1 J. Campistol,1 M. Sole,2 F. Oppenheimer.1

    1Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain; 2Pathology, Hospital Clínic, Barcelona, Spain; 3Transplant Foundation, Hospital Clínic, Barcelona, Spain; 4Urology, Hospital Clínic, Barcelona, Spain.

    There is no consensus of selection criteria used to allocate renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) has been…
  • 2016 American Transplant Congress

    Eary Use of Statins Associated with Improved Death-Censored Graft Survival Following Kidney Transplant.

    T. Horwedel,1 D. Brennan,2 K. Lentine,3 J. Hagopian.1

    1Barnes-Jewish Hospiptal, St. Louis, MO; 2Washington University School of Medicine, St. Louis, MO; 3St. Louis University, MO.

    Purpose: The impacts of statin therapy on patient and graft outcomes after kidney transplantation (KT) are controversial.Methods: We performed a retrospective cohort study of adult…
  • 2016 American Transplant Congress

    CD9+ Regulatory B Lymphocytes Control Chronic Lung Inflammation by Inducing Effector T Cell Apoptosis.

    C. Brosseau,1,2 M. Durand,1 F. Braza,1 E. Durand,2 J. Loy,2 P. Lacoste,2 P. Royer,2 M.-A. Cheminant,2 A. Magnan,2 S. Brouard.1

    1ITUN-INSERM U1064, Nantes, France; 2Institut du thorax, INSERM U1087/CNRS U6291, Nantes, France.

    Several observations highlight the relevance of regulatory B cells (Breg) to clinical transplantation. We have identified a new Breg population expressing the CD9, able to…
  • 2016 American Transplant Congress

    Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.

    V. Cantaluppi,1 S. Dellepiane,2 D. Medica,2 G. Tognarelli,2 M. Quaglia,1 C. Musetti,1 A. Airoldi,1 L. Biancone.2

    1Nephrology, Dialysis and Kidney Transplantation Unit, University of Eastern Piedmont "A. Avogadro", Novara, Italy; 2Nephrology, Dialysis and Kidney Transplantation Unit, University of Torino, Torino, Italy.

    Anti-HLA antibodies (abs) bind to kidney graft endothelial cells inducing complement-mediated injury and humoral rejection. Endothelial Progenitor Cells (EPC) are bone marrow-derived precursors able to…
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