ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Utility of Six-Minute-Walk Distance in Predicting Lung Transplant Benefit in the Lung Allocation Score Era.

    S. Shah,1 D. Tumin,3 B. Whitson,2 A. Pope-Harman,1 S. Kirkby,1 A. Kilic,2 P. Lee,2 D. Hayes.1,3

    1Pulmonary and Critical Care, Ohio State University Wexner Medical Center, Columbus, OH; 2Division of Cardiac Surgery, Ohio State University Wexner Medical Center, Columbus, OH; 3Pediatrics, Ohio State University, Columbus, OH.

    Transplant physicians evaluate patients for lung transplant (LTx) who are on ventilators and ECMO with high lung allocation scores (LAS). Six-minute walk distance (6MWD) predicts…
  • 2016 American Transplant Congress

    Combination of Veto Cell Transfer and iNKT Cell Therapy Establishes Complete Hematopoietic Chimerism in Non-Myeloablative BMT Recipients.

    R. Ishii,1 T. Hirai,1 Y. Ishii,2 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Laboratory for Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.

    Hematopoietic chimerism after non-myeloablative bone marrow transplantation (nmBMT) has been found beneficial for establishment of transplant tolerance. Since bone marrow cells (BMCs) are endowed with…
  • 2016 American Transplant Congress

    Would Transplanting Kidneys Currently Being Discarded in the US Place Programs at Risk for Regulatory Review?

    J. Snyder, N. Salkowski, B. Thompson, A. Wey, A. Israni, B. Kasiske, S. Leppke.

    Scientific Registry of Transplant Recipients, Minneapolis.

    In the US in 2014, 17,188 potential kidneys were available from 8594 deceased donors (2014 SRTR/OPTN Annual Data Report). Of these, 25% were not recovered…
  • 2016 American Transplant Congress

    Analysis of Intra-Graft Anti-HLA Antibodies Suggests That HLA Sensitization Occurs Long After an Allograft Nephrectomy and Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney.

    D. Milongo,1 N. Congy-Jolivet,2 A. Del Bello,1 F. Sallusto,3 L. Esposito,1 L. Rostaing,1 N. Kamar.1

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Department of Immunology, CHU Rangueil, Toulouse, France; 3Department of Urology and Kidney Transplantation, CHU Rangueil, Toulouse, France.

    Background: The mechanism leading to the appearance of anti-HLA antibodies and donor-specific antibodies (DSAs) after an allograft nephrectomy (NTx) is not fully understood. Two mechanisms…
  • 2016 American Transplant Congress

    Optimal Donor/Recipient Pairing for High KDPI Grafts Can Yield Similar Survival to Medium KDPI Grafts.

    M. Selim, E. Saad, M. Zimmerman, C. Johnson.

    Medical College of Wisconsin, Milwaukee.

    KDPI is a predictor of deceased-donor (DD) graft survival, calculated using donor factors. It does not consider recipient or other post-procurement factors. This retrospective analysis…
  • 2016 American Transplant Congress

    Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.

    M. Lubetzky,1 P. O Broin,2 Y. Bao,1 E. Akalin.1

    1Transplantation, Albert Einstein College of Medicine, Bronx; 2School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.

    Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
  • 2016 American Transplant Congress

    High Efficacy of Ledipasvir/Sofosbuvir with Ribavirin in HCV Genotype-1 Infected Patients with Decompensated Liver Disease: Analysis by MELD Score from the SOLAR-1 and SOLAR-2 Trials.

    M. Charlton,1 E. Yoshida,2 M. Bouliere,3 S. Flamm,4 A. Muir,5 M. Fried,6 N. Terrault,7 S. Arterburn,8 C. Yun,8 P. Pang,8 A. Osinusi,8 J. Spellman,8 M. Natha,8 D. Brainard,8 J. McHutchison,8 M. Manns,9 N. Afdhal.10

    1Intermountain Medical Center, Salt Lake City; 2Vancouver General Hospital, Vancouver, Canada; 3Hopital Saint Joseph, Marseilles, France; 4Northwestern University, Chicago; 5Duke University, Durham; 6University of North Carolina, Chapel Hill; 7UCSF, SF; 8Gilead Sciences Inc, Foster City; 9Hannover Medical School, Hannover, Germany; 10BIDMC, Boston.

    Introduction: HCV infected patients with decompensated liver disease have significant morbidity & mortality. The efficacy & safety of LDV/SOF + RBV was evaluated in a…
  • 2016 American Transplant Congress

    Early Post Renal Transplant aHUS in Patients with Heterozygous CFHR3-CFHR1 Deletion.

    S. Rhazouani, A. Malone, T. Alhamad, T. Maw, D. Brennan, R. Delos Santos.

    Renal Division, Washington University, Saint Louis, MO.

    Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease with a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Subjects homozygous for…
  • 2016 American Transplant Congress

    Learning Curve of Laparoscopic Donor Nephrectomy for Abdominal Transplant Surgery Fellows.

    O. Serrano,1 A. Bangdiwala,2 D. Vock,3 V. Kirchner,1 T. Dunn,1 E. Finger,1 T. Pruett,1 A. Matas,1 R. Kandaswamy.1

    1Surgery, Univ. of Minnesota, Minneapolis, MN; 2Biostatistics, Masonic Cancer Center, Minneapolis, MN; 3Biostatistics, Univ. of Minnesota, Minneapolis, MN.

    PURPOSE: Laparoscopic donor nephrectomy (LDN) requires a high degree of surgical competence and skill. UNOS recommends that fellowship-trained surgeons participate in 15 LDN to be…
  • 2016 American Transplant Congress

    Phenotype and Outcome of Antibody-Mediated Rejection Due to Pre-Existing and De Novo DSA in Kidney Recipients.

    O. Aubert,1 A. Loupy,1 L. Hidalgo,2 J. Reeve,3 D. Glotz,1 C. Legendre,1 C. Lefaucheur,1 P. Halloran.3

    1Paris Research Center for Organ Transplantation, Paris, France; 2University of Alberta, Edmonton, Canada; 3ATAGC, Edmonton, Canada.

    Antibody-mediated rejection (ABMR) presents with either pre-existing or de novo DSA. The aim of the study was to compare the two ABMR phenotypes and their…
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