Am J Transplant, Volume 16, Suppl 3 Archives - Page 30 of 180 - ATC Abstracts

2016 American Transplant Congress
Evaluating Posttransplant BKV-Specific T Cell Responses in Patients with Alemtuzumab Induction and Belatacept-Based Regimen.
M. McRae, T. How, A. Kirk, H. Xu.
Department of Surgery, Duke University, Durham, NC.
Belatacept-based maintenance regimens prevent acute allograft rejection following alemtuzumab induction, and patients so treated maintain intact anti-CMV and -EBV T cell immune responses without viral…
2016 American Transplant Congress
Digital Kidney Biopsy Evaluation: Quantification of Macrophage Prevalence in a Cross Sectional Study.
J. Schmitz,¹ A. Khalifa,¹ H. Haller,² H. Kreipe,¹ F. Feuerhake,¹ J. Bräsen.¹
¹Institute of Pathology, Hannover Medical School, Hannover, Germany; ²Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Standardized markers based on quantitative and qualitative evaluation of immune cell mass and localization in kidney biopsies may help in diagnosis and prognosis in transplantation…
2016 American Transplant Congress
Presence of Highly Immunogenic Mismatch Eplets Is Associated with Development of Chronic Active Antibody-Mediated Rejection: A First Report from Japan.
D. Iwami, K. Morita, H. Sasaki, H. Higuchi, Y. Takada, N. Shinohara.
Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Backgrounds: De novo donor specific antibody (dnDSA) correlates with chronic active antibody-mediated rejection (CAAMR), a major leading cause of graft loss. It will be a…
2016 American Transplant Congress
Absence of Host CD137 Signaling Converts Chronic GVHD Toward Acute GVHD.
H. Cho,^1,3 J. Lee,^1,4 J. Kim,¹ U. Moon,¹ B. Kwon,^1,2 S. Park,³ K. Park.⁴
¹Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; ³Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.
CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…
2016 American Transplant Congress
IL-17A Preactivated Mesenchymal Stem Cells (MSC-17) Are Enriched for Genes Involved in T Cell Chemotaxis to Mediate Superior Immunosuppression.
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Gronthos,⁴ S. Grey,⁵ P. Coates.^1,2,3
¹School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ²Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research and Robinson Institute, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁴Mesenchymal Stem Cell Laboratory, School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁵Transplant Immunology Group, Garvin Institute of Medical Research, Sydney, New South Wales, Australia.
Human bone marrow derived MSC-17 are superior T cell immunomodulators for allotransplantation. Untreated-MSC (UT-MSC) or 5 days IFNγ (MSCγ) or IL-17A (MSC-17) treated MSC were…
2016 American Transplant Congress
TNT009 and Its Parental Mouse Monoclonal Antibody TNT003 Target Complement Component C1s and Effectively Block Alloantibody-Induced Classical Complement Pathway Activation – The Preclinical Experience.
M. Wahrmann,¹ J. Mühlbacher,¹ H. Regele,¹ F. Eskandary,¹ J. Gilbert,² S. Panicker,² G. Böhmig.¹
¹VIETAC Laboratories, Medical University of Vienna, Vienna, Austria; ²True North Therapeutics, Inc., South San Francisco, CA.
Introduction. Considering the key role of the classical complement pathway as a trigger of inflammation and injury in antibody-mediated rejection (ABMR), targeted classical pathway inhibition…
2016 American Transplant Congress
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.
L. Gallon,¹ J. Leventhal,¹ C. Dumur,² J. Mathew,¹ L. Nadimpalli,¹ A. Shetty,¹ S. Ildstad,³ V. Mas.²
¹Medicine/Nephrology, Northwestern University, Chicago, IL; ²Medicine/Nephology, University of Virginia Health System, Charlottesville, VA; ³Immunology, University of Louisville, Louisville, KT.
Organ transplantation relies upon nonspecific immunosuppressive (IS) agents to prevent graft rejection. However, IS drugs have significant toxicities and chronic rejection occurs despite their usage.…
2016 American Transplant Congress
Rapid Detection of Acute Infection in Immunosuppressed Renal Patients with IRIDICA: A Pilot Study.
S. Hassan,¹ A. Adwaney,¹ A. Massiah,² R. Murphy,² S. Law,¹ S. Mohd-Afzal,¹ M. Wilks,² R. Thuraisingham.¹
¹Renal, Royal London Hospital, Barts Health Trust, London, United Kingdom; ²Microbiology, Barts Health Trust, London, United Kingdom.
BackgroundThe Abbott IRIDICA bacterial bloodstream (BAC BSI) assay is a rapid semi-quantitative diagnostic test that is able to detect over 800 significant pathogens using PCR…
2016 American Transplant Congress
Donor-Derived Toxoplasmosis in Solid Organ Transplant 2008 – 2015: Opportunities for Improvement.
C. Wolfe,¹ A. Wilk,² S. Tlusty,² C. Sifri,¹ M. Morris,¹ A. Mehta,¹ D. Kaul.¹
¹DTAC, Richmond, VA; ²United Network for Organ Sharing, Richmond, VA.
Background: Donor-derived Toxoplasmosis (DDT) is uncommon, but outcomes may be poor. Donor risk factors are difficult to recognize, and donor screening is not currently universally…
2016 American Transplant Congress
Outcomes in Black vs Non-Black Patients Administered Belatacept (Bela) or Cyclosporine (CsA) in BENEFIT-EXT.
S. Florman,¹ A. Durrbach,² V. Duro Garcia,³ K. Calderon,⁴ U. Meier-Kriesche,⁴ M. Polinsky,⁴ H. Zhao,⁴ J. Medina Pestana.⁵
¹Mount Sinai Med Ctr, New York; ²Univ Hôpital of Bicêtre, Le Kremlin-Bicêtre, France; ³Hosp Dom Vicente Scherer, Porto Alegre, Brazil; ⁴BMS, Lawrenceville; ⁵Hosp do Rim, Sao Paulo, Brazil.
Studies consistently show worse outcomes for black vs non-black kidney transplant recipients. At 7 yrs post-transplant in BENEFIT-EXT (NCT00114777), bela was associated with similar graft…