ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Adenovirus Infection in Kidney Transplant Recipients: Report of a Case Series.

    C. Simancas-Ruiz, L. Marino-Vazquez, A. Meraz-Muñoz, A. Nuñez-Abreu, R. Rivera-Marfil, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplant and Pathology, National Institute of Medical Sciences and Nutrition SZ, México, DF, Mexico.

    Introduction: In kidney transplant recipients, the incidence of adenovirus infection is 4.1%, usually occur in the first three months after transplantation. Patients may have viral…
  • 2016 American Transplant Congress

    Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.

    J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.

    Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
  • 2016 American Transplant Congress

    Expansion of Anti-HLA Antibodies After Renal Transplantation and Prognosis in Those Which Fix C1q.

    P. Ruiz-Esteban,1 M. Gonzalez-Molina,1 A. Caballero,2 A. Torio,2 M. Leon,3 E. Palma,1 D. Burgos,1 M. Cabello,1 V. Lopez,1 M. Rodriguez,4 D. Hernandez.1

    1Nephrology, Regional University Hospital, IBIMA, University of Malaga, Malaga, Spain; 2Immunology, Regional University Hospital, IBIMA, University of Malaga, Malaga, Spain; 3Pathology, Regional University Hospital, IBIMA, University of Malaga, Malaga, Spain; 4Nephrology, Torrecardenas Hospital, Almeria, Spain.

    Introduction. Antibody-mediated rejection (ABMR) is the major cause of allograft failure. We studied the evolution and prognostic effect of pre-formed and de novo anti-HLA antibodies…
  • 2016 American Transplant Congress

    In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells – A Novel Approach for Tolerance Induction in Transplantation.

    M. Siemionow, E. Tfaily, M. Cyran, R. Gendek, M. Strojny, E. Szilagyi, J. Cwykiel.

    Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.

    Background: Cell-based therapies represent a new promising approach for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…
  • 2016 American Transplant Congress

    Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.

    E. Montanari,1 R. Meier,2 D. Bosco,1 R. Mahou,3 P. Morel,2 J. Seebach,4 C. Wandrey,3 C. Gonelle-Gispert,1 L. Bühler.2

    1University of Geneva, Geneva, Switzerland; 2Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; 3Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 4Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.

    Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
  • 2016 American Transplant Congress

    Necroptosis Is Involved in CD4+ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.

    C. Kwok,1,2 N. Montwill,1,2 A. Pavlosky,1,2 A. Haig,2 X.-Y. Huang,1 A. Jevnikar,1,3 Z.-X. Zhang.1,2,3

    1Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada; 2Department of Pathology and Laboratory Medicine, Western University, London, Canada; 3Department of Medicine, Western University, London, Canada.

    Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…
  • 2016 American Transplant Congress

    Acquired Down-Regulation of B Cell Function Induced by Donor Blood Group Antigens After ABO-Incompatible Kidney Transplantation.

    M. Tasaki,1 K. Saito,1 Y. Nakagawa,1 N. Imai,2 T. Aoki,3 M. Kamimura,3 K. Takahashi,1 Y. Tomita.1

    1Division of Urology, Department of Regenerative & Transplant Medicine, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan; 2Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; 3Division of Transfusion Medicine and Regenerative Medicine Bioscience Medical Center, Niigata University Medical and Dental Hospital, Niigata, Japan.

    Background: The long-term of B cell immunobiology against donor blood group antigen has not been elucidated in ABO incompatible kidney transplantation (ABOi KTx).Methods: The antibody…
  • 2016 American Transplant Congress

    Analysis of a Large Single-Center Cohort of Renal Transplant Recipients with Histoplasmosis.

    M. Mashayekhi, A. Langone.

    Internal Medicine, Vanderbilt University Medical Center, Nashville, TN.

    The dimorphic fungus Histoplasma capsulatum is endemic along the Ohio and Mississippi River Valleys and can cause clinically significant disease in those with impaired cellular…
  • 2016 American Transplant Congress

    In Situ Aortic Flush with Lactated Ringer's (LR) Solution During Donation After Brain Death (DBD) Organ Procurement Provides Similar Outcomes and Significantly Decreases Costs in Kidney and Liver Transplantation Compared to Standard Preservation Solutions.

    S. Rudich, P. Lange.

    Medical Division, Gift of Life Michigan, Ann Arbor, MI.

    PURPOSE: To determine if LR, when used as the initial in situ aortic flush during DBD renal and hepatic procurement, was safe, effective, and non-inferior…
  • 2016 American Transplant Congress

    Long-Term Outcomes in Epstein-Barr Virus (EBV)-Positive Patients Receiving Belatacept (Bela) or Cyclosporine (CsA) in BENEFIT-EXT.

    S. Florman,1 J. Medina Pestana,2 M. del C Rial,3 L. Rostaing,4 D. Kuypers,5 A. Matas,6 T. Wekerle,7 J. Grinyó,8 U. Meier-Kriesche,9 M. Polinsky,9 H. Zhao,9 A. Durrbach.10

    1Mount Sinai Med Ctr, New York; 2Hosp do Rim, Sao Paulo, Brazil; 3Instituto de Nefrologia, Buenos Aires, Argentina; 4Univ Hosp, Toulouse, France; 5Univ Hosp Leuven, Leuven, Belgium; 6Univ of Minnesota, Minneaopolis; 7Med Univ of Vienna, Vienna, Austria; 8Univ Hosp Bellvitge, Barcelona, Spain; 9BMS, Lawrenceville; 10Univ Hôpital of Bicêtre, Le Kremlin-Bicêtre, France.

    At 7 yrs post transplant in BENEFIT-EXT (NCT00114777), bela-treated pts had similar graft survival and improved renal function vs CsA-treated pts. Bela is indicated for…
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