2016 American Transplant Congress
Tailored Rabbit Anti-Thymocyte Globulin Induction (rATG) Dosing for Kidney Transplantation.
1MMC, Portland, ME; 2MGMC, Augusta, ME.
Purpose: Although rATG is the most commonly used induction immunotherapy for kidney transplantation (KT), optimal dosing remains unknown. In order to minimize adverse effects and…2016 American Transplant Congress
Toll-Like Receptor (TLR) 9-Induced Resistance to Murine Cardiac Allograft Tolerance Is Dependent Upon C3a and C5a Receptor (C3aR/C5aR) Signaling.
TLR stimulation has been shown by others to prevent costimulatory blockade-induced allograft tolerance. Immune cell derived complement activation products C3a and C5a amplify inflammation, enhance…2016 American Transplant Congress
Tolerogenic Interactions Between Host CD8+Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.
Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…2016 American Transplant Congress
Short Duration Perioperative Administration of Ledipasvir/Sofosbuvir Is Safe and Effective in Preventing HCV Recurrence After Liver Transplant.
Background:The optimal timing and duration of DAA therapy in HCV patients undergoing liver transplant(LT) is unknown. CRUSH-C is an open-label, Phase 2 study evaluating the…2016 American Transplant Congress
Where Are the KDPI 0-20% Kidneys Going in the New KAS? A Major Allocation Shift.
1Univ Hosp Case Med Ctr, Cleveland, OH; 2Emory Univ, Atlanta, GA; 3UNOS, Richmond, VA.
The introduction of KAS in December 2014 marked an effort to incorporate a longevity metrics into deceased organ allocation by prioritizing retrieved kidneys with the…2016 American Transplant Congress
Blockade of HLA Antibody-Triggered Classical Complement Activation by High-Affinity Humanized Monoclonal Anti-C1s Antibody TNT009 – Results of a First-in-Human Phase 1 Trial.
Study purpose: Classical complement may play a key role in ABMR. A promising therapeutic approach could be complement inhibition at the level of key component…2016 American Transplant Congress
Complexity of Hylinosis in Renal Transplant Biopsies: Donor Age, Glomerular Disease, and Time.
Arteriolar hyalinosis lesions (ah) are often interpreted as a sign of calcineurin inhibitor toxicity even though they are induced by other conditions. We studied the…2016 American Transplant Congress
Large Single-Center Experience of Sofosbuvir and Ledipasvir Therapy for the Treatment of Post-Liver Transplant Patients with Hepatitis C Virus.
Medicine, Emory University, Atlanta, GA.
Background/Aims: Controlled trials of direct acting antiviral therapy for Hepatitis C Virus (HCV) show impressive sustained virologic response (SVR) rates, but post-transplant data of sofosbuvir…2016 American Transplant Congress
Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.
1Surgery, UVA, Charlottesville, VA; 2VCU, Richmond; 3NWU, Chicago.
Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…2016 American Transplant Congress
Living Donor Kidney Transplant Outcomes Have Improved Over the Last Decade.
Medicine, University of Virginia, Charlottesville, VA.
Our group recently reported improved 6-month eGFR and long-term patient and allograft outcomes in deceased donor transplant over the last decade. Our goal was to…
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