Am J Transplant, Volume 16, Suppl 3 Archives - Page 22 of 180 - ATC Abstracts

2016 American Transplant Congress
Combined CD122 and Costimulation Blockade Prolongs Allograft Survival by Controlling Expansion and Effector Function of Memory CD8 T Cells.
D. Mathews,¹ Y. Dong,¹ L. Higginbotham,¹ S. Kim,¹ C. Breeden,¹ J. Tso,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²JN Biosciences, Mountain View, CA.
CD8 memory T cells rely on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. The addition of anti-CD122 to costimulation blockade prolongs graft…
2016 American Transplant Congress
Dilution of Patient Sera Improves MFI Correlation with Complement Fixation in Solid Phase Assay Assessment.
C. Castleberry,¹ D. Phelan,² K. Simpson,¹ T. Mohanakumar,³ C. Canter.¹
¹Pediatric Cardiology, Washington University School of Medicine, St. Louis, MO; ²Histocompatibility Laboratory, Barnes-Jewish Hospital, St. Louis, MO; ³Surgery, Washington University School of Medicine, St. Louis, MO.
Background: Median Fluorescent Intensity (MFI) by solid phase assays (SPA) has been used to determine risk of donor-recipient reaction prior to transplant. Inconsistency of this…
2016 American Transplant Congress
NAD⁺Promotes Allograft Survival Independently of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells.
A. Elkhal, H. Rodriguez Cetina Biefer, H. Uehara, M. Quante, M. Seyda, J. Schuitenmaker, S. Tullius, A. Elkhal.
Surgery, Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance and T cell homeostasis. It is known that Tregs promote…
2016 American Transplant Congress
Designing and Synthesizing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Long Term Heart Allograft Acceptance While Reducing Plasma Cells and Donor Specific Antibodies.
A. Mihali,¹ E. Sula Karreci,¹ A. Kurdi,³ L. Riella,¹ Y. Kawano,³ H. Fan,² P. Singh,² I. Ghobrial,³ C. Nathan,² G. Lin,² J. Azzi.¹
¹Transplantation Research Center, Harvard Medical School, Boston; ²Department of Microbiology and Immunology, Weill Cornell Medicine, NY; ³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston.
Antibody mediated rejection (AMR) is one of the most important barriers to improving long-term transplant outcomes. Traditional therapies for AMR do not deplete the source…
2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
M. Shimamura,¹ M. Li,² B. Chen,² J. George,² T. Schoeb.³
¹Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; ²Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
2016 American Transplant Congress
Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.
M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
2016 American Transplant Congress
Pediatric Access to Kidney Transplantation Under KAS.
W. Cherikh,¹ D. Stewart,¹ A. Kucheryavaya,¹ M. Aeder,² E. Brewer.³
¹UNOS, Richmond, VA; ²Univ. Hosp. Case Med Ctr, Cleveland, OH; ³Texas Children's Hosp/Baylor College Medicine, Houston, TX.
Background. Under the kidney allocation system (KAS) implemented on Dec 4, 2014, pediatric (ped) priority is now based on Kidney Donor Profile Index (KDPI) <35%…
2016 American Transplant Congress
Who Should Decide? Potential Living Kidney Donor Preferences for Making Decisions About Risk.
C. Thiessen,¹ J. Gannon,¹ K. Kennedy,² D. Dobosz,¹ S. Li,¹ D. Gray,³ A. Mussell,³ E. Gordon,² P. Reese,³ S. Kulkarni.¹
¹Yale U, New Haven; ²Northwestern U, Chicago; ³U Pennyslvania, Philadelphia.
BackgroundTransplant centers debate how to manage risks to potential living kidney donors (LKDs) when there is a lack of consensus about reasonable donor risk .We…
2016 American Transplant Congress
Mycophenolic Acid Product Discontinuation Prior to Conception: Analysis of Pregnancies in Kidney Transplant Recipients.
S. Constantinescu,^1,2 L. Coscia,² D. Armenti,² M. Moritz.^2,3
¹Medicine, Temple University, Philadelphia, PA; ²Gift of Life Institute, National Transplantation Pregnancy Registry (NTPR), Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA.
Mycophenolic acid (MPA) products are considered teratogenic and transplant centers report discontinuing MPA in female kidney recipients anticipating pregnancy. Data were collected by the National…
2016 American Transplant Congress
B Cell Signature Profiling in Kidney Transplant Patients on Thymoglobulin.
A. Benitez,¹ T. Milford,² K. Torralba,³ K. Payne,² M. De Vera.¹
¹Transplantation Institute, Loma Linda University Health Care, Loma Linda, CA; ²Basic Science Division of Anatomy, Loma Linda University, Loma Linda, CA.
Purpose: B cell subsets could be used as biomarkers to modulate therapy regimens in kidney transplant patients. B cell subsets occur with varying proportions within…