Am J Transplant, Volume 16, Suppl 3 Archives - Page 22 of 180 - ATC Abstracts

2016 American Transplant Congress
Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.
L. Boneschansker,^1,2 D. Irimia,² D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston; ²MGH, Boston.
Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…
2016 American Transplant Congress
Impact of Early Calcineurin Inhibitor Withdrawal on Renal Function and Urinary Protein Excretion: 24 Month Analyses of the ELEVATE Study.
J. de Fijter,¹ H. Holdaas,¹ M. Seelen,¹ S. Sundar,¹ F. Bemelman,¹ P. Lopez,² J. Aguilar,² P. Bernhardt,² Z. Wang,³ J. Cruzado,¹ M. van der Giet.¹
¹ELEVATE study group, Leiden, Netherlands; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover, NJ.
Background: Proteinuria is a biomarker which helps in predicting graft outcomes in kidney transplant recipients (KTxRs). The ELEVATE study was designed to determine whether an…
2016 American Transplant Congress
Predictors of Early Rejection and Allograft Failure in Pediatric Kidney Transplantation: Impact of Histology and Behavior.
M. Seifert, M. Yanik, R. Mannon.
University of Alabama at Birmingham School of Medicine, Birmingham.
Background: Early inflammatory events that lead to allograft dysfunction are often missed by creatinine-based estimates in children. Surveillance biopsies can detect early allograft dysfunction due…
2016 American Transplant Congress
Have We Gone Too Far Defining Performance Outliers? One-Third of Kidney Transplant Programs Now Identified for Low Performance within Three Years.
J. Schold,¹ C. Miller,¹ M. Henry,² L. Buccini,¹ S. Flechner,¹ D. Goldfarb,¹ E. Poggio,¹ K. Andreonni.³
¹Cleveland Clinic, Cleveland, OH; ²Ohio State University, Columbus, OH; ³University of Florida, Gainesville, FL.
Transplant center report cards developed by SRTR are publicly available and utilized for regulatory oversight and insurance contracting. There are significant associations of performance oversight…
2016 American Transplant Congress
Clinical Rejection-Risk Assessment with Allospecific CD154+T-Cytotoxic Memory Cells (CD154+TcM) After Pediatric Liver or Intestine Transplantation (LTx, ITx).
K. Soltys, G. Bond, G. Mazariegos, L. O'Toole, C. Trautz, L. Remaley, A. Zeevi, C. Ashokkumar, R. Sindhi.
Surgery, Children's Hosp of Pgh of UPMC & Univ of Pittsburgh, Pittsburgh, PA.
Background: In preclinical evaluation, CD154+TcM predict acute cellular rejection after LTx or ITx with sensitivity/specificity of 80%. Purpose/Methods: To summarize test indications and performance during…
2016 American Transplant Congress
Serum Bicarbonate and Long-Term Outcomes in Kidney Transplant Recipients.
S. Park,¹ E. Kang,¹ M. Han,¹ J. Park,¹ S. Yang,² S. Park,³ I. Jung,⁴ C. Lim,⁵ Y. Kim,¹ Y. Kim,⁶ J. Lee.⁵
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea; ⁴Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea; ⁵Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ⁶Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Background: Metabolic acidosis indicated by low serum bicarbonate (TCO2) level has been known as a risk factor for mortality and progressive renal dysfunction in patients…
2016 American Transplant Congress
Tailored Rabbit Anti-Thymocyte Globulin Induction (rATG) Dosing for Kidney Transplantation.
N. Singh,^1,2 A. Rossi,¹ M. Savic,¹ R. Rubocki,¹ M. Parker,¹ J. Vella.¹
¹MMC, Portland, ME; ²MGMC, Augusta, ME.
Purpose: Although rATG is the most commonly used induction immunotherapy for kidney transplantation (KT), optimal dosing remains unknown. In order to minimize adverse effects and…
2016 American Transplant Congress
Toll-Like Receptor (TLR) 9-Induced Resistance to Murine Cardiac Allograft Tolerance Is Dependent Upon C3a and C5a Receptor (C3aR/C5aR) Signaling.
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR stimulation has been shown by others to prevent costimulatory blockade-induced allograft tolerance. Immune cell derived complement activation products C3a and C5a amplify inflammation, enhance…
2016 American Transplant Congress
Tolerogenic Interactions Between Host CD8⁺Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.
D. Hongo Apum,¹ X. Zhang,² E. Engleman,² S. Strober.¹
¹Medicine - Division of Immunology & Rheumatology, Stanford University, Stanford, CA; ²Medicine - Department of Pathology, Stanford University, Stanford, CA.
Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…
2016 American Transplant Congress
Short Duration Perioperative Administration of Ledipasvir/Sofosbuvir Is Safe and Effective in Preventing HCV Recurrence After Liver Transplant.
E. Verna,¹ J. Levitsky,² J. O'Leary,³ N. Bzowej,⁴ D. Moonka,⁵ R. Hyland,⁶ D. Brainard,⁶ J. McHutchison,⁶ N. Terrault.⁷
¹Columbia Univ., NY; ²Northwestern Univ., Chicago; ³Baylor Univ., Dallas; ⁴Ochsner Clinical Foundation, New Orleans; ⁵Henry Ford Hospital, Detroit; ⁶Gilead Sciences, Foster City; ⁷UCSF, San Francisco.
Background:The optimal timing and duration of DAA therapy in HCV patients undergoing liver transplant(LT) is unknown. CRUSH-C is an open-label, Phase 2 study evaluating the…