Am J Transplant, Volume 16, Suppl 3 Archives - Page 180 of 180 - ATC Abstracts

2016 American Transplant Congress
Tracking of Endogenous Graft-Reactive Tregs Reveals Their Peripheral Enrichment During Transplantation Tolerance.
J. Young,¹ J. Chen,¹ M. Miller,¹ D. Yin,¹ J. Moon,² M.-L. Alegre,¹ A. Chong.¹
¹Surgery and Medicine, University of Chicago, Chicago, IL; ²Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA.
Purpose: Our goal for this study was to determine the relative fates of endogenous Foxp3- conventional (Tconv) and Foxp3+ regulatory T cells (Tregs) specific for…
2016 American Transplant Congress
Enhanced IL-6 Production Impedes Transplant Tolerance Induction in Lupus-Prone Mice.
B. Stocks, C. Wilson, M. Seto, A. Marshall, D. Moore.
Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.
Significance: Autoimmunity is a significant barrier to transplantation. Based on previous studies, it is apparent that there are separate genetic regions that control susceptibility to…
2016 American Transplant Congress
Pregnancy Outcomes in 17 Female Heart Transplant Recipients with the Initial Diagnosis of Congenital Heart Defect.
L. Coscia,¹ D. Armenti,¹ S. Constantinescu,^1,2 M. Moritz.^1,3
¹Gift of Life Institute, National Transplantation Pregnancy Registry (NTPR), Philadelphia; ²Medicine, Temple University, Philadelphia; ³Surgery, Lehigh Valley Health Network, Allentown.
The purpose of this study was to describe pregnancy in female heart recipients whose indication for transplantation was due to congenital heart defect. Data were…
2016 American Transplant Congress
How Did the New Kidney and Pancreas Allocation Systems Effect Pancreas Utilization in the First Six-Months?
R. Carrico,¹ J. Fridell,² J. Odorico,³ Z. Stewart.⁴
¹UNOS, Richmond, VA; ²Indiana Univ School of Medicine, Indianapolis, IN; ³Univ of Wisconsin Hospital and Clinics, Madison, WI; ⁴Univ of Iowa Hospital and Clinics, Iowa City, IA.
Background: In 2010 a new pancreas allocation system (PAS) was approved by the OPTN and implemented in October 2014, shortly preceding the new kidney allocation…
2016 American Transplant Congress
CTLA4 Negatively Regulates Donor-Reactive CXCR5+PD1+ T Follicular Helper Cell Responses Following Transplantation.
I. Badell,¹ D. Liu,¹ S. Suchard,² S. Nadler,² M. Ford.¹
¹Emory Transplant Center, Atlanta; ²Bristol-Myers Squibb, Princeton.
Costimulation blockade of the CD28 pathway in the form of CTLA4Ig is known to attenuate T cell dependent antibody responses. T follicular helper (Tfh) cells…
2016 American Transplant Congress
Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection of Vessel Allografts by Effector Memory T Cells.
P. Abrahimi,¹ L. Qin,² W. Chang,¹ A. Bothwell,¹ G. Tellides,² W. Saltzman,³ J. Pober.¹
¹Immunobiology, Yale School of Medicine, New Haven, CT; ²Surgery, Yale School of Medicine, New Haven, CT; ³Biomedical Engineering, Yale University, New Haven, CT.
Acute allograft rejection is mediated by alloreactive CD8+ T cells that differentiate into cytotoxic lymphocytes (CTL). In most rodent models, CTL differentiate from naïve CD8+…