Am J Transplant, Volume 16, Suppl 3 Archives - Page 176 of 180 - ATC Abstracts

2016 American Transplant Congress
Parainfluenza-3 Infections Early After Kidney Transplantation.
I. Helanterä,¹ V.-J. Anttila,² M. Lempinen.¹
¹Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; ²Department of Infectious Diseases, Helsinki University Hospital, Helsinki, Finland.
A. Purpose: Parainfluenza (PIV) is able to cause serious and even fatal infections after hematopoietic stem cell and lung transplantation. Limited data are available about…
2016 American Transplant Congress
Enhanced Natural Killer Responsiveness Is a Potent Cytotoxic Mechanism Associating to Kidney Allograft Dysfunction and Pathogenic Effects of Donor-Specific Antibodies (DSA).
P. Paul,^1,2 T. Legris,³ C. Picard,⁴ D. Todorova,^1,2 L. Lyonnet,¹ L. Daniel,⁵ B. Dussol,^3,6 V. Moal,³ H. Vacher Coponat,³ Y. Berland,³ F. Dignat-George,^1,2 S. Burtey.^2,3
¹Hematology, Assistance Publique Hopitaux Marseille, Marseille, France; ²UMR-1076, VRCM, Aix Marseille University, INSERM, Marseille, France; ³Nephrology Dialysis Renal Transplantation Center, Assistance Publique Hopitaux Marseille, Marseille, France; ⁴Immunogenetics, Etablissement Français du Sang, Marseille, France; ⁵Anatomy, Pathology, Neuropathology, Assistance Publique Hopitaux Marseille, Marseille, France; ⁶Center for Clinical Investigation, Assistance Publique Hopitaux Marseille, Marseille, France.
While antibody mediated rejection (ABMR) is a major cause of kidney transplant loss, the role of Natural Killer cells (NK) as immune effectors of complement-independent…
2016 American Transplant Congress
Factors Mediating Kidney Rejection in Patients of Simultaneous Liver-Kidney Transplants.
R. Dong, A. Tambur, L. Gallon, J. Levitsky.
Northwestern, Chicago, IL.
BACKGROUND & AIM: Kidney grafts in simultaneous liver-kidney (SLK) recipients are considered to be immunologically protected due to hepatic tolerance, although recent studies have alternatively…
2016 American Transplant Congress
Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.
J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
2016 American Transplant Congress
A Novel, Non-Viral mRNA Delivery System for Targeted Protein Translation in Human Islets.
J. Oberholzer,^1,2 D. Gutierrez,^1,2 E. Marchese,¹ M. Nourmohammadzadeh,^1,2 Y. Wang.^1,2
¹Department of Surgery, University of Illinois at Chicago, Chicago, IL; ²Department of Bioengineering, University of Illinois at Chicago, Chicago, IL.
Background: We propose using an innovative technology that utilizes gold nanoparticles (AuNPs) as a non-viral method of delivery. Our laboratory was one of the first…
2016 American Transplant Congress
NKG2A-Expressing Natural Killer Cells Dominate the Response to Latent Epstein-Barr Virus Infection.
O. Hatton,¹ D. Strauss-Albee,² S. Krams,¹ C. Blish,² O. Martinez.¹
¹Surgery, Stanford University School of Medicine, Stanford, CA; ²Medicine, Stanford Univerity School of Medicine, Stanford, CA.
Introduction: EBV infection elicits a robust host immune response in healthy, immunocompetant individuals. EBV immunity is essential for preventing EBV-associated lymphomas in transplant recipients, including…
2016 American Transplant Congress
Ex Vivo Expansion and Functional Characterization of Human Alloantigen-Specific Regulatory T Cells.
J. Mathew,¹ S. McEwen,¹ I. Konieczna,¹ X. Huang,¹ J. He,¹ R. Kornbluth,² J. Miller,¹ L. Gallon,¹ J. Leventhal.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Multimeric Biotherapeutics, Inc, La Jolla, CA.
Purpose: Regulatory T cells (Tregs) have been associated with clinical transplant tolerance and they have been shown to prolong graft survival in animal models without…
2016 American Transplant Congress
Vaccination Compliance in Listed Kidney Transplant Candidates: A Retrospective Chart Review.
I. Tawhari,¹ C. Staffeld-Coit,² J. Garcia-Diaz.¹
¹Infectious Disease, Ochsner Health System, New Orleans, LA; ²Nephrology, Ochsner Health System, New Orleans, LA.
Background: Infections in solid organ transplant recipients, some of which are vaccine preventable, may result in excessive morbidity and mortality. Immunosuppressive agents increase the risk…
2016 American Transplant Congress
Innate Immune Signaling During Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² C. Lassman,¹ R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,¹ E. Reed.¹
¹Pathology and Lab Medicine, University of California-Los Angeles, Los Angeles, CA; ²Surgery, University of California-Los Angeles, Los Angeles, CA.
Background: Orthotopic liver transplantation (OLT) success is hampered by cellular damage elicited by ischemia-reperfusion injury (IRI) which lowers allograft survival. Research using murine models has…
2016 American Transplant Congress
Successful Prophylactic Use of Eculizumab in aHUS Kidney Transplant Patients: A Report of 9 Cases.
A. Kumar,¹ Z. Stewart,³ A. Reed,³ D. Orozco,² R. Smith,^1,2 C. Nester,^1,2 C. Thomas.^1,2
¹Internal Medicine, Univ of Iowa, Iowa City; ²Pediatrics, Univ of Iowa, Iowa City; ³Surgery, Univ of Iowa, Iowa City.
AHUS is a thrombotic microangiopathy (TMA) triggered by alternate complement pathway (AP) dysregulation. In 60% of patients, a pathogenic variant can be identified in one…