Am J Transplant, Volume 16, Suppl 3 Archives - Page 174 of 180 - ATC Abstracts

2016 American Transplant Congress
Initial Experience Treating Hepatitis C Positive Kidney Transplant Recipients with Non-Interferon-Containing Regimens: Successes and Challenges.
M. Aull, A. Watkins, J. Kim, K. Rhee, D. Dadhania, J. Lee, S. Kapur.
Weill Cornell Medical College, New York, NY.
Historically, treatment of hepatitis C virus (HCV) infection with interferon-based regimens after kidney transplantation has been associated with risk of rejection & graft loss. Direct…
2016 American Transplant Congress
Gsk3β Regulates Macrophage Pro-Inflammatory Immune Activation via AMPK-Mediated Induction of Small Heterodimer Partner (SHP).
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; ³Liver Surgery, Renji Hospital, Shanghai, China.
Background & AimsAlthough glycogen synthase kinase 3 β (Gsk3β) has been found to play key roles in ischemia and reperfusion injuries (IRI) of different organs,…
2016 American Transplant Congress
Blockade of the ASC Coreceptor Enhances Hematopoietic Stem Cell Engraftment.
R. Elahimehr, S. Kasimsetti, A. Shigeoka, D. McKay.
UCSD, San Diego.
Purpose: HSC engraftment is essential for successful bone marrow transplantation, and successful HSC engraftment allows for induction of tolerance to solid organ allografts. Engrafted HSCs…
2016 American Transplant Congress
Donor-Derived Toll-Like Receptor-Dependent Intravascular Monocytes Cause Primary Lung Graft Dysfunction.
S. Chiu, Z. Zheng, H. Sun, M. DeCamp, Jr, G. Budinger, H. Perlman, A. Misharin, A. Bharat.
Northwestern University, Chicago, IL.
Purpose: Neutrophils mediate primary lung allograft dysfunction (PGD), the predominant cause of early graft loss following lung transplant. The mechanisms of neutrophil infiltration remain incompletely…
2016 American Transplant Congress
Understanding the Initial Rise in Kidney Discard Rates Observed Post-KAS.
D. Stewart,¹ A. Kucheryavaya,¹ R. Brown,¹ D. Klassen,¹ N. Turgeon,² M. Aeder.³
¹UNOS, Richmond, VA; ²Emory Univ, Atlanta, GA; ³Univ Hosp Case Med Ctr, Cleveland, OH.
Background: Kidney discard rates increased by 10% -- from 18.3% to 20.2% (p=0.001) -- during the first 7 months of KAS but returned to pre-KAS…
2016 American Transplant Congress
Investigating Posttransplant Allo-Donor Specific CD57⁺ Cells in Patients with Alemtuzumab Induction and Belatacept-Based Regimen.
H. Xu, F. Feng, A. Kirk.
Department of Surgery, Duke University, Durham, NC.
Recent studies have showed correlation between CD4+CD57+PD1- cells and costimulation blockade resistant rejection (CoBRR) in patients treated with belatacept without depletional induction. We have recently…
2016 American Transplant Congress
Pulse Pressure and GFR Decay in Kidney Transplant Recipients.
O. Sanchez, S. Reule, R. Spong, N. Issa, A. Kukla, A. Matas, H. Ibrahim.
U of MN, Mpls.
Single blood pressure values have commonly been used to assess the risk of allograft failure in kidney transplant recipients. In this analysis we prospectively evaluated…
2016 American Transplant Congress
A Pathway to Belatacept Monotherapy: Alemtuzumab, Belatacept and Rapamycin for Kidney Transplantation.
A. Guasch,¹ H. Xu,² A. Mehta,¹ A. Ghali,¹ S. Mead,¹ H. Gebel,¹ R. Bray,¹ C. Larsen,¹ T. Pearson,¹ A. Kirk.²
¹Emory Transplant Center, Atlanta, GA; ²Duke University, Durham, NC.
Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…
2016 American Transplant Congress
IgG Dilutions, Subclasses, C1q, and IgM: Determining Relevant Testing for De Novo DSA and Outcome Prediction.
M. Everly,¹ L. Rebellato,² C. Haisch,² K. Briley,² P. Bolin,² S. Kendrick,³ C. Morgan,² A. Maldonado,⁴ A. Nguyen,¹ P. Terasaki.¹
¹Terasaki Foundation Laboratory, Los Angeles; ²East Carolina University, Greenville, NC; ³Eastern Nephrology Associates, Greenville, NC; ⁴Vidant Medical Center, Greenville, NC.
Numerous publications have shown secondary antibody testing of IgG (subclasses, C1q, etc) in de novo DSA (dnDSA) positive patients may have clinical relevance. Herein, we…
2016 American Transplant Congress
Nondirected Kidney Donation – Donating More Than a Kidney.
C. Jacobs,¹ J. Wiseman,¹ D. Berglund,¹ D. Larson,¹ C. Garvey,¹ M. Vogues,¹ S. Rein,¹ O. Sanchez,¹ C. Radecki Breitkopf,² H. Ibrahim,¹ A. Matas.¹
¹U of MN, Mpls; ²Mayo Clinic, Rochester.
Little is known about donation-related out-of-pocket costs incurred by NDD. For NDD, we studied: resources used to cover these costs; level of stress due to…