Am J Transplant, Volume 16, Suppl 3 Archives - Page 174 of 180 - ATC Abstracts

2016 American Transplant Congress
Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.
G. Furtmüller,¹ B. Oh,¹ M. Fryer,^1,4 P. Akre,¹ S. Ganguly,² J. Dodd-o,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; ³Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; ⁴Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.
Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
L. Wang,¹ A. Beeler,² S. Dahiya,¹ R. Han,¹ W. Hancock.¹
¹CHOP & UPenn, Philadelphia, PA; ²Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…
2016 American Transplant Congress
Comparison of C4d Deposition in Renal Biopsies with Luminex-Based C3d Single Antigen Bead (SAB) Detection.
R. Pelletier,¹ I. Balazs,² P. Adams,³ P. Steller,³ N. DiPaola,⁴ L. Rankin,³ A. Diez,⁵ M. Henry.¹
¹Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Discovery Research, Immucor, Inc, Stamford, CT; ³Tissue Typing, The Ohio State University Wexner Medical Center, Columbus, OH; ⁴Methodist Hospital, Houston, TX; ⁵Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
Recent interest in characterizing the complement-fixing ability of post-transplant donor specific alloantibodies (DSA) resulted in the enhancement of luminex solid phase alloantibody assays to determine…
2016 American Transplant Congress
Polyclonal Treg Adoptive Therapy for Control of Subclinical Kidney Transplant Inflammation (TASK Pilot Trial).
S. Chandran, Q. Tang, M. Sarwal, Z. Laszik, A. Putnam, T. Sigdel, E. Tavares, J. Bluestone, F. Vincenti.
UCSF, San Francisco, CA.
Purpose: Early renal graft inflammation is associated with progressive fibrosis & late dysfunction. Treg therapy can reverse established inflammation in animal models. We conducted a…
2016 American Transplant Congress
Beyond the Bones – The Association Between Vitamin D, Graft Outcomes and Vascular Disease.
A. Cherukuri,¹ S. Balasubramanian,² R. Molyneux,² R. Baker.
¹UPMC, Pittsburgh; ²University of Leeds, Leeds, United Kingdom.
Background: Vitamin D deficiency in KTRs is an emerging theme. The purported associations between Vitamin D deficiency and various metabolic, cardiovascular and non-metabolic adverse events…
2016 American Transplant Congress
Time Course of Hepatic Graft Function Improvement After Ledipasivir/Sofosbuvir Treatment in Liver Transplant Recipients with HCV and Fibrosis or Cirrhosis Who Achieved SVR.
S. Helmke,¹ J. O'Leary,² J. Burton,¹ M. Cookson,¹ S. Lauriski,¹ J. Trotter,² J. McHutchison,³ G. Everson.¹
¹University of Colorado, Aurora, CO; ²Baylor University Medical Center, Dallas, TX; ³Gilead Sciences, Inc., Foster City, CA.
Background: In SOLAR-1, liver transplant recipients with HCV and either fibrosis or cirrhosis were treated at baseline with ledipasvir/sofosbuvir and ribavirin for 12 or 24…
2016 American Transplant Congress
Treatment of Hepatitis C Viral Infection with Novel Direct Acting Antivirals in Kidney Transplant Recipients – Single Center Experience.
K. Hatahet,¹ M. Ghanta,¹ A. Gillespie,¹ I. Lee,¹ H. El-Halawany,² K. Qureshi,² K. Lau,³ S. Karhadkar,³ A. Di Carlo,³ S. Constantinescu,¹ S. Rao.¹
¹Nephrology, Temple University, Phildelphia, PA; ²Hepatology, Temple University, Philadelphia, PA; ³Surgery, Temple University, Philadelphia, PA.
Kidney transplant recipients (KTRs) with Hepatitis C virus infection (HCV+ve) have higher proteinuria and inferior patient and graft survival compared to HCV negative KTRs. Due…
2016 American Transplant Congress
Acute Operative Complications and 1,5,& 10 Year Outcomes in Living Donors by Type of Live Donor Nephrectomy – UK Cohort Study.
N. Krishnan,¹ L. Bradbury,² N. Raymond.¹
¹Renal & Transplantation, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom; ²Statistics, National Health Service, Organ Donation & Transplant, Bristol, United Kingdom.
It is important to have a better understanding of the short and long term outcomes and risks of kidney donation. We studied the occurrence of…
2016 American Transplant Congress
Epitope Load Is Predictive of De Novo Donor Specific Antibodies Occurrence in Renal Transplant Recipients After Conversion from Cyclosporine to Everolimus.
R. Snanoudj,¹ C. Suberbielle,² N. Kamar,³ E. Cassuto,⁴ S. Caillard,⁵ J.-L. Taupin,² D. Anglicheau,¹ C. Legendre,¹ A. Hertig,⁶ E. Rondeau.⁶
¹Necker Hospital, Paris, France; ²Saint-Louis Hospital, Paris, France; ³Rangueil Hospital, Toulouse, France; ⁴Pasteur Hospital, Nice, France; ⁵CHRU, Strasbourg, France; ⁶Tenon Hospital, Paris, France.
IntroductionThe degree of HLA compatibility between donor and recipient is an important risk factor of developing de novo DSA, but misjudged by the number of…
2016 American Transplant Congress
Predonation Prescription Narcotic Use: A Novel Risk Factor for Readmission After Living Donor Nephrectomy.
K. Lentine,^1,7 D. Segev,^2,1 D. Axelrod,³ N. Lam,⁴ A. Garg,⁵ G. Hess,⁶ B. Kasiske,¹ D. Brennan,⁸ H. Randall,⁷ M. Schnitzler.^7,1
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Johns Hopkins, Baltimore; ³Dartmouth, Hanover; ⁴Univ Alberta, Alberta, Canada; ⁵Western Univ, London, Canada; ⁶Symphony Health, Pittsburgh; ⁷Saint Louis Univ, St. Louis.
Implications of narcotic use in living kidney donor (LKD) candidates for key outcomes, including readmission rates after nephrectomy, are unknown.We integrated 1) national Scientific Registry…