ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Enabled PRA and Precision PRA: Alternatives to cPRA as Desensitization Trial Endpoints.

    E. Woodle, M. Pando Rigal, S. Tremblay, A. Girnita.

    U of Cincinnati, Cincinnati; Mayo Clinic Scottsdale, Scottsdale.

    Transplant (Transplant) rate is an optimal endpoint in desensitization (DS) trials in HLA sensitized Txp candidates, however, for waitlisted Txp candidates, wait time heterogeneity compromises…
  • 2016 American Transplant Congress

    The Prevailing Preference for Left Nephrectomy in Living Donor Transplantation Does Not Adversely Affect Long Term Donor Outcome.

    S. Robertson,1 L. Garrard,1 S. Farid,1 R. Baker,1 N. Ahmad,1 M. Attia,1 R. Feltbower,2 M. Jameel,1 H. Lutz.1

    1Department of Transplantation, St. James' University Hospital, Leeds, United Kingdom; 2Department of Statistics, University of Leeds, Leeds, United Kingdom.

    Background: There is a world-wide prevailing clinical bias for removing the left kidney for living donor renal transplant. Both the retrieval and implantation of the…
  • 2016 American Transplant Congress

    Gender Bias and Kidney Transplantation in Nepal.

    S. Rasmussen,1 P. Paneru,2 D. Segev,1 A. Massie,1 P. Shrestha.3

    1JHU, Baltimore; 2BPKIHS, Dharan, Nepal; 3Human Organ Transplant Center, Bhaktapur, Nepal.

    Gender bias in live kidney donation (LKD) is well documented globally but is particularly extreme in Nepal, where 84% of recipients, but only 25% of…
  • 2016 American Transplant Congress

    A Novel Quantitative CD45 Immunofluorescence Assay Can Measure Inflammatory Load in Renal Transplant Biopsies with Excellent Reproducibility and Repeatability.

    Z. Laszik,1 D. Dobi,1 L. Laszik,1 D. Ikle,2 S. Chandran,1 F. Vincenti.1

    1UCSF, San Francisco, CA; 2Rho, Chapel Hill, NC.

    Purpose: The interobserver reproducibility of the current standard semiquantitative (Banff) grading of inflammation in renal transplant biopsies (TxBx) is suboptimal. We have recently developed a…
  • 2016 American Transplant Congress

    Cytokine Networks in Kidney Transplant Patients.

    R. Sabat,1 E. Witte,1 P. Reinke,2 K. Wolk,1 N. Babel.3,4

    1Interdisciplinary Group Molecular Immunopathology, and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, Charite University Medicine Berlin, Berlin, Germany; 2Department of Nephrology and Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany; 3Medical Clinic I, Marien Hospital Herne, University Clinic Ruhr-University Bochum, Herne, Germany; 4Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany.

    As key mediators of the intercellular communication, cytokines play a crucial role in many processes following transplantation, including inflammation, tissue regeneration, and anti-microbial defense. Locally…
  • 2016 American Transplant Congress

    Assessing the Role of Everolimus in Reducing Hepatocellular Carcinoma Recurrence After Living Donor Liver Transplantation for Patients within UCSF Criteria: Re-Inventing the Role of Mammalian Target of Rapamycine Inhibitors.

    L.-B. Jeng, A. Thorat, H.-R. Yang, T.-H. Chen, S.-C. Hsu.

    Organ Transplantation, China Medical University Hospital, Taichung, Taiwan.

    The antineoplastic effects of everolimus(EVR) in adjuvant to its conventional immunosuppressive role in post-transplant setting can theoretically reduce the tumor recurrence in hepatocellular carcinoma(HCC)patients undergoing…
  • 2016 American Transplant Congress

    Cytokine Storm in Acute Post-Hepatectmy Phase Associates with Liver Injury and Impaired Liver Regeneration.

    Y. Xu,1,2 N. Navarro-Alvarez,1 J. Dong,2 J. Markmann,1 H. Yeh.1

    1Transplantation Division, Massachusetts General Hospital, Boston, MA; 2Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.

    Background Posthepatectomy liver failure and its transplant counterpart, small-for-size syndrome, remain poorly understood. Large increases in IL-6 are associated with poor allograft function and IL-6…
  • 2016 American Transplant Congress

    Quality of Postoperative Pain Care in Living Liver Donors.

    M. Mandell,1 A. Smith,2,6 D. Gordon,3 S. Holtzman,4 M. Dew,5 T. Howell,6 A. DiMartini,5 Z. Butt,8 M. Simpson,7 C. Freise,9 S. McCluskey,10 R. Fisher,11 J. Guaerra,12 K. Olthoff,13 E. Pomfret.7

    1U of Colorado, Denver; 2Arbor Research Collaborative for Health, Ann Arbor; 3U of Washington, Seattle; 4U of British Columbia, Okanagan, Canada; 5U of Pittsburgh, Pittsburgh; 6U of Michigan, Ann Arbor; 7Lahey, Burlington; 8Northwestern U, Chicago; 9U of California at San Francisco, San Francisco; 10U of Toronto, Toronto, Canada; 11Virginia Commonwealth U, Richmond; 12Columbia U, New York; 13U of Pennsylvania, Philadelphia.

    Background: Postoperative pain (POP) is the strongest predictor of chronic pain syndromes (Katz and Seltzer, Expert Rev Neurother 2009), however little is known about POP…
  • 2016 American Transplant Congress

    Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.

    S. Yilmaz,1 D. Shaffer,2 Y. Qazi,3 F. Shihab,4 K. McCague,5 D. Patel,5 F. Vincenti.6

    1University of Calgary, Calgary, AB, Canada; 2Vanderbilt University, Nashville, TN; 3University of Southern California, Los Angeles, CA; 4University of Utah, Salt Lake City, UT; 5Novartis Pharmaceuticals Corporation, East Hanover, NJ; 6University of California San Francisco, San Francisco, CA.

    Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
  • 2016 American Transplant Congress

    Chronic Infection by Hepatitis C Virus and the Development of Transplant Glomerulopathy.

    D. Regidor,1 S. Alexandru,5 M. Martínez,3 N. Polanco,4 E. González,4 A. Serrano,2 J. Morales.4

    1Nephrology, H.Virgen de la Salud, Toledo, Spain; 2Immunology, Instituto de Investigación H. Doce de Octubre, Madrid, Spain; 3Pathology, H.Doce de Octubre, Madrid, Spain; 4Nephrology, H.Doce de Octubre, Madrid, Spain; 5Nephrology, H.Rey Juan Carlos, Madrid, Spain.

    OBJETIVE: To demonstrate that chronic infection with the hepatitis C virus (HCV) is a risk factor for the development of transplant glomerulopathy in a large…
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