Am J Transplant, Volume 16, Suppl 3 Archives - Page 16 of 180 - ATC Abstracts

2016 American Transplant Congress
Thymus Is Required for T Cells Reconstitution Following Antibody-Mediated Lymphoablation.
K. Ayasoufi, R. Fan, A. Valujskikh.
Cleveland Clinic, Cleveland.
Antibody-mediated lymphocyte depletion is used as induction therapy in sensitized transplant recipients. Following lymphoablation, peripheral lymphopenia triggers homeostatic T cell proliferation (HP) and enhanced thymopoiesis.…
2016 American Transplant Congress
Prospective Randomized OPEN Trial Designed to Reduce the Incidence of Cytomegalovirus (CMV) Infection in DE NOVO Kidney Transplant Recipients Two-Year Results.
R. Esmeraldo, M. Oliveira, P. Pinheiro, C. Girao, T. Freitas.
Transplant, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil.
Introduction: CMV infection is a frequent complication following organ transplantation, and is associated with inferior long-term patient and graft survival. Here we report the results…
2016 American Transplant Congress
Non-Invasive Biomarkers for Graft Quality and Outcome Post-Liver Transplantation.
R. Gehrau, V. Mas, S. Bontha, D. Maluf.
Surgery, UVA, Charlottesville, VA.
Background: Graft quality is a determinant of graft function after liver transplantation (LT). This study aimed to evaluate graft molecular markers that correlate to peripheral…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Evaluation of the Long-Term Outcomes with Everolimus After Calcineurin Inhibitor Withdrawal: 36M Results of the H2304 and PROTECT Extension Studies.
L. Fischer,^1,2 J. Fung,¹ H. Metselaar,¹ G. Kaiser,^1,2 P. Schemmer,² P. Neuhaus,² G. Dong,³ P. Lopez,⁴ P. Bernhardt,⁴ H. Schlitt.²
¹H2304 study group, Hamburg, Germany; ²PROTECT study group, Hamburg, Germany; ³Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁴Novartis Pharma AG, Basel, Switzerland.
Background: The H2304 and PROTECT studies demonstrated reduced nephrotoxicity with everolimus (EVR)-based calcineurin inhibitor (CNI; cyclosporine: CsA, tacrolimus: TAC)-free regimens at Month (M) 12. Here,…
2016 American Transplant Congress
Pregnancy Excludes Women from Successful Living Donor Transplantation.
P. Porrett,¹ B. Bromberger,² S. Hashmi,¹ A. Morrison,¹ D. Sawinski.³
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Columbia University, New York, NY; ³Medicine, University of Pennsylvania, Philadelphia, PA.
INTRODUCTION Pregnancy-induced sensitization (PIS) is a barrier to the transplantation of women and contributes significantly to gender disparity in transplantation. We hypothesized that this barrier…
2016 American Transplant Congress
Donors with Isolated Anti-HBc (“HBcAb Only”) Antibodies: True Evidence for Past Infection or Laboratory Artifact? Toward a Simple Confirmatory Test for HBcAb.
Y. Chang,^1,3 C. Chinchilla-Reyes,² M. Koss,^1,2 M. Nowicki.^1,2
¹Mendez National Institute of Transplantation Foundation, Los Angeles, CA; ²Viracor-IBT Laboratories, Los Angeles, CA; ³Western University of Health Sciences, Pomona, CA.
Use of organs from donors positive for hepatitis B virus (HBV) markers may safely expand the donor pool. Recently the American Society of Transplantation expert…
2016 American Transplant Congress
Donor-Derived Monocytes Migrate to the Contralateral Lung and Cause Neutrophilia Following Single Lung Transplant.
S. Chiu, Z. Zheng, H. Sun, M. DeCamp, Jr, G. Budinger, H. Perlman, A. Misharin, A. Bharat.
Northwestern University, Chicago, IL.
Purpose: Deterioration of the native lung from lung injury occurs in the majority of patients following single lung transplant, but its pathogenesis remains unknown. Here,…
2016 American Transplant Congress
Effect of Adipose Tissue-Derived Mesenchymal Stem Cells in a Rat Model of Chronic Renal Allograft Rejection.
R. Pepineli, F. Silva, P. Gouveia, G. Tavora, S. Gomes, I. Noronha.
Renal Division, University of Sao Paulo, Sao Paulo, Brazil.
Adipose tissue-derived mesenchymal stem cells (ASC) may represent a new strategy to prevent allograft rejection after kidney transplantation due to its immunomodulatory properties. In the…
2016 American Transplant Congress
HLA Identical Renal Transplant Tolerance Using Donor Hematopoietic Stems Cells (DHSC): Role of Immunoregulation.
J. Leventhal,¹ J. Mathew,¹ D. Salomon,² S. Kurian,² J. Friedewald,¹ L. Gallon,¹ X. Huang,¹ A. Tambur,¹ Y. Kanwar,¹ J. Charette,¹ M. Abecassis,¹ J. Miller.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²The Scripps Research Institute, La Jolla, CA.
Purpose: Despite being a “perfect match”, HLA-identical kidney transplants (HLA-Id KTx) are rejected without sufficient immunosuppression (IS), and hence can also benefit from tolerance induction.…