2016 American Transplant Congress
HO-1/SIRT1/p53 Axis Regulates Macrophage Activation and Attenuates Liver Ischemia-Reperfusion Injury in Mice.
Background/Aim: The mechanism by which macrophage heme oxygenase-1 (HO-1)-Sirtuin1 (SIRT1) signaling promotes resistance against inflammation response in liver ischemia-reperfusion injury (IRI) remains elusive. As tumor…2016 American Transplant Congress
Thoracic Simulation Allocation Modeling (TSAM) of a 6-Tier Allocation Strategy.
Heart allocation policy (OPTN policy 6) is in development. To stratify medical urgency, the Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tier algorithm…2016 American Transplant Congress
Are Prior Living Kidney Donors with ESRD Being Listed and Receiving Transplantation Priority in a Timely Manner?
BackgroundPrior living donors (PLDs) receive very high priority on the kidney (KI) waiting list (WL). Programs must submit requests for PLD priority to the UNOS…2016 American Transplant Congress
Post-Transplant Monitoring of Donor-Specific Anti-HLA Antibodies and Their Characteristics Improves Risk Stratification of Kidney Allograft Loss.
Circulating donor-specific anti-HLA antibodies (DSA) are associated with allograft failure in solid-organ transplantation. We investigated the pathogenic characteristics of DSA that may improve risk prediction…2016 American Transplant Congress
Geographic Differences in Racial Disparity Reduction in Kidney Transplant Rates Before and After the New Kidney Allocation System.
1Emory University, Atlanta; 2Columbia University, New York.
Background: Prior to the new kidney allocation system (KAS) implemented 12/4/2014, significant African American (AA) vs. white racial disparities existed in access to kidney transplantation…2016 American Transplant Congress
Black Ethnicity as a Risk Factor for Poor Kidney Allograft Outcomes Post-Transplantation.
Introduction: Registry studies, largely from the United States, have consistently demonstrated inferior outcomes for black patients undergoing renal transplant. A recent Canadian publication has challenged…2016 American Transplant Congress
Successful Treatment of Hepatitis C in Renal Transplant Recipients with Directly Acting Antiviral Agents.
Background: Hepatitis C infection (HCV) in kidney transplant (KTx) recipients has been shown to be a risk factor for decreased patient and allograft survival. With…2016 American Transplant Congress
Evaluation of Scoring Systems Predicting Patient Survival at Time of Kidney Transplantation.
Nephrology, Charite, Berlin, Germany.
Introduction:Estimating life expectancy in kidney transplant recipients (KTR) at time of transplantation is important to achieve the best functional match between patient and graft survival.…2016 American Transplant Congress
Blocking Fc Receptor in Flow Cytometric Crossmatch: Refining an Old Assay to Improve Patient Management.
Pathology, University of Chicago, Chicago, IL.
Introduction: The crossmatch assay is used to determine sensitization of solid organ transplant recipients to donor-expressed HLA molecules, a potential contraindication to transplant. Multicolor flow…2016 American Transplant Congress
Evaluation of the Toxicity Profile of Proteasome Inhibitor-Based Therapy for Antibody Mediated Rejection.
1U of Cinncinati, Cincinnati; 2The Christ Hospital, Cincinnati.
Background: Experience with bortezomib (BTZ) antibody mediated rejection (AMR) therapy has progressively increased over the past few years. The BTZ toxicity profile in the transplant…
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