Am J Transplant, Volume 16, Suppl 3 Archives - Page 151 of 180 - ATC Abstracts

2016 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo.
K. Bonner, N. Moore, M. Moreno Gonzales, M. Stegall.
Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Introduction:Plasma cells (PCs) are a major source of alloantibody in transplant patients.They are resistant to current therapy. Since receptor/ligand interactions in the stromal environment are…
2016 American Transplant Congress
End-Stage Renal Disease Does Not Impair the Large-Scale Generation of Potent Alloantigen-Specific Regulatory T Cells for Immunotherapy.
N. Litjens, K. Boer, J. Zuijderwijk, M. Klepper, A. Peeters, W. Verschoor, R. Kraaijeveld, C. Baan, M. Betjes.
Internal Medicine, Nephrology and Transplantation, Erasmus University Medical Centre, Rotterdam, Netherlands.
Background Alloantigen-specific natural occurring regulatory T cells (nTregs) have the potential to offer a more targeted approach of immunosuppression and are the cell type of…
2016 American Transplant Congress
The Role and Mechanism of CD40/CD40L Expression on Different T-Cell Subsets.
N. Granofszky, K. Hock, B. Mahr, N. Pilat-Michalek, T. Wekerle.
Department of Surgery, Section of Transplantation Immunology, Medical University of Vienna, Vienna, Austria.
Background: Several T-cell costimulatory pathways (i.e. CD28:B7 and CD40:CD40L) play a critical role in modulating alloreactivity, but their function on distinct T cell subsets remains…
2016 American Transplant Congress
Results of Biopsies in Pancreas and Kidney-Pancreas Patients with Graft Dysfunction.
P. Uva, L. Leon, E. Minue, I. Cabrera, A. Giunippero, M. Norese, M. Toniolo, E. Chuluyan, D. Casadei.
Nephrology, Buenos Aires, Argentina.
In pancreas transplantation there is no reliable laboratory test or imaging study for detection of graft rejection. There is an increasing interest in obtaining pancreas…
2016 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation for Chronic Pancreatitis: Considerations for Early Intervention.
J. Jolissaint,¹ L. Langman,¹ C. DeBolt,¹ A. Wang,² D. Strand,² V. Zaydfudim,¹ R. Adams,¹ K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Medicine, University of Virginia, Charlottesville, VA.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) provides pain relief for patients with chronic pancreatitis (CP) and the potential to ameliorate the resulting endocrine insufficiency.…
2016 American Transplant Congress
Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?
L. Cendales,¹ M. Levine,² S. Bartlett,³ J. Cheeseman,¹ C. Drachenberg,³ W. Hancock,⁴ M. Joshi,¹ A. Kirk,¹ F. Leoopardi,¹ S. Levin,² M. Uluer,³ A. Selim,⁵ M. Song,¹ W. Twaddell,³ L. Wang,⁴ Z. Wang,² R. Barth.³
¹Surgery, Duke University, Durham, NC; ²University of Pennsylvania, Philadelphia, PA; ³University of Maryland School of Medicine, Baltimore, MD; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ⁵Pathology, Duke University, Durham, NC.
Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
2016 American Transplant Congress
Live Donor Kidney Transplantation of the Most Highly Sensitized Patients in the Era of Kidney Paired Donation.
A. Bingaman,¹ F. Wright,¹ M. Kapturczak,¹ L. Shen,¹ C. Murphey.²
¹Transplant, Methodist Specialty and Transplant Hospital, San Antonio, TX; ²Southwest Immunodiagnostics, Inc., San Antonio, TX.
Background: Despite effective kidney paired donation (KPD) programs, the most highly sensitized patients (calculated panel reactive antibody (cPRA) > 98%) remain significantly disadvantaged and accumulate…
2016 American Transplant Congress
Hepatitis C Patients in a Multicenter Study Who Received Living Donor Liver Transplants Are Likely to Have Increased Survival.
J. Kim,¹ K.-W. Lee,² G.-W. Song,³ B.-H. Jung,³ H. Lee,⁴ N.-J. Yi,² C. Kwon,¹ S. Hwang,³ K.-S. Suh,² J.-W. Joh,¹ S.-K. Lee,¹ S.-G. Lee.³
¹Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; ²Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea; ³Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ⁴Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea.
Background: No consensus has been reached regarding comparisons of outcomes for patients with hepatitis C virus (HCV) who received living donor liver transplantation (LDLT) versus…
2016 American Transplant Congress
NanoString Detection of Gene Signatures in Urine During Acute Cellular Rejection of Kidney Grafts.
K. Keslar,¹ A. Zmijewska,² J. Andriga,² K. Newell,³ R. Mannon,² P. Heeger,⁴ R. Fairchild.¹
¹Cleveland Clinic, Cleveland; ²UAB, Birmingham; ³Emory, Atlanta; ⁴MSSM, New York.
Considerable effort has focused on identification of gene expression patterns that may assist in diagnosis of acute cellular rejection. The NanoString platform offers a novel…
2016 American Transplant Congress
Acute Allograft Glomerulopathy: A Distinct Form of Cellular Rejection.
O. AL-Badri, M. Alexander, F. Cosio, L. Cornell.
Mayo Clinic, Rochester, MN.
Background: Acute allograft glomerulopathy (AAG) is an unusual glomerular lesion of allografts with endocapillary hypercellularity, markedly enlarged endothelial cells occluding the capillary lumen, and absence…