Am J Transplant, Volume 16, Suppl 3 Archives - Page 136 of 180 - ATC Abstracts

2016 American Transplant Congress
Association of Neighborhood Poverty and Living Donor Kidney Transplant Rates by Donor Relationship to Recipient.
G. Vranic, A. Nishio Lucar, D. Keith.
Medicine, University of Virginia, Charlottesville, VA.
Background: Living donor (LD) kidney transplant is associated with increased access to transplant and improved patient and allograft outcomes. Despite the known benefits, LD rates…
2016 American Transplant Congress
Is C3d-fixing Donor Specific HLA Antibody Detection Really Necessary?
P. Malvezzi,¹ M. Villemaire,¹ A. Bourdin,² T. Jouve,¹ R. Tetaz,¹ B. Janbon,¹ N. Terrier,³ D. Masson.²
¹Service de Néphrologie, Grenoble University Hospital, Grenoble, France; ²Laboratoire d'Histocompatibilité, EFS, Grenoble, France; ³Service d'Urologie, Grenoble University Hospital, Grenoble, France.
Introduction: Chronic antibody–mediated rejection is the main cause of late kidney graft loss. The identification of donor-specific antibodies (DSA) in the serum is one of…
2016 American Transplant Congress
Malignancies Contribute to Presensitization with Alloreactive T-Cells in Kidney Transplant Recipients.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Alloreactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute rejection in the initial period after kidney transplantation. Knowledge…
2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
2016 American Transplant Congress
Accumulation of Highly Sensitized Patients in a KPD Registry.
S. Stepkowski, B. Mierzejewska, D. Bekbolsynow, M. Rees.
University of Toledo, Toledo, OH.
Objectives: We analyzed sensitization against HLA among patients in a kidney paired donation (KPD) registry. In particular, three groups of patients were included: 1) all…
2016 American Transplant Congress
Prediction of Patient Survival After Kidney Transplantation: Construction, Validation and Evaluation of Decision Models Using Data Mining Approaches.
I. Scheffner,¹ K. Hua,² D. Simovici,² T. Abeling,¹ H. Haller,¹ W. Gwinner.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Computer Science, University of Massachusetts, Boston.
Understanding the risk factors that predispose to death is important in order to deliver the most appropriate therapy to patients (pts) with kidney transplantation (Tx).…
2016 American Transplant Congress
ER Stress and Loss of GRP78 Expression Provides a Link Between Renal Ischemia/Reperfusion Injury and the Urinary Metabolome.
C. van Kooten,¹ T. Pacchiarotta,² P. van der Pol,¹ J. de Fijter,¹ N. Schlagwein,¹ D. van Gijlswijk,¹ O. Mayboroda.²
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²Centre for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Ischemia/reperfusion injury (IRI) profoundly impacts graft survival following kidney transplantation. Epithelial injury is one of the earliest histological alterations of IRI and is especially observed…
2016 American Transplant Congress
The Role of B Cells in Liver Transplant Tolerance.
M. Morita,² G. Enyindah-Asonye,¹ N. Gupta,¹ J. Fung,² S. Qian,^1,2 L. Lu.^1,2
¹Immunology, LernerResearch Institute, Cleveland Clinic, Cleveland, OH; ²General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Scarcely one would argue that donor-specific B cells and antibodies contribute to rejection of transplants. However, studies published in the past few years have provided…
2016 American Transplant Congress
Learning from Cancer: Using D-Lactate for Therapeutic Immunosuppression.
U. Beier,¹ J. Jiao,¹ H. Xiao,¹ A. Angelin,² D. Wallace,² M. Levine,³ W. Hancock.⁴
¹Pediatric Nephrology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Surgery, University of Pennsylvania, Philadelphia, PA; ⁴Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Univerisity of Pennsylvania, Philadelphia, PA.
Accumulation of lactic acid in the tumor microenvironment contributes to local immunosuppressive conditions that weaken anti-tumor immunity. Lactic acid exists as L- and D- optical…
2016 American Transplant Congress
Kidney Allotransplantation Induces the Differentiation of Antigen-Experienced CD8 T Cells with Enhanced Metabolic Profiles.
G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 S. Brouard,^1,3 C. Pecqueur,⁴ N. Degauque.^1,3
¹UMR 1064, INSERM, Nantes, France; ²Université de Nantes, Nantes, France; ³ITUN, CHU de Nantes, Nantes, France; ⁴UMR 892, INSERM, Nantes, France.
Background. Naïve and memory CD8 T cells have been shown to exhibit different metabolic profiles, especially upon antigen stimulation. However, it is unknown whether the…