ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    A Sustained Viral Response Achieved with Sofosbuvir/Ledipasvir May Increase the Incidence of Acute Cellular Rejection Post Liver Transplantation.

    K. Bortecen, R. Layman, B. Gelb, A. Winnick, G. Morgan, H. Tobias, L. Teperman.

    Transplant Surgery, New York University Langone Medical Center, New York, NY.

    Acute cellular rejection following liver transplantation has decreased in incidence with the use of potent immunosuppressive agents, affecting less than 25 percent of liver transplantation…
  • 2016 American Transplant Congress

    Smoking Exposure Among Kidney Allograft Recipients and Outcomes After Transplant.

    H. Gillott,1 S. Tahir,1 F. Jackson-Spence,1 F. Evison,2 J. Nath,3 A. Sharif.3

    1Medical School, University of Birmingham, Birmingham, United Kingdom; 2Medical Informatics, Queen Elizabeth Hospital, Birmingham, United Kingdom; 3Nephrology and Transplantation, Queen Elizabeth Hospital, Birmingham, United Kingdom.

    The causal effects of smoking on major comorbidity and mortality in the general population are well established. However, the influence of smoking exposure on kidney…
  • 2016 American Transplant Congress

    Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.

    M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.

    University of Florida, Gainesville, FL.

    Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
  • 2016 American Transplant Congress

    Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.

    Y. Liu, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    Surgery, The Houston Methodist, Houston, TX.

    Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…
  • 2016 American Transplant Congress

    Administration of IL-33 Before Allogeneic Stem Cell Transplantation Expands Recipient Treg That Prevent Graft- vs. Host Disease.

    B. Matta,1 D. Reichenbach,2 X. Zhang,1 B. Koehn,2 L. Mathews,1 C. Feser,2 M. Smith,2 Q. Liu,1 R. Zeiser,3 B. Blazar,2 H. Turnquist.1

    1Dept of Surgery and Starzl Transplant Inst, Univ of Pittsburgh Sch of Med, Pittsburgh, PA; 2Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; 3Univ Med Cntr Freiburg, Freiburgh, Germany.

    Background: During allogeneic hematopoietic cell transplantation (alloHCT), non-hematopoietic cell IL-33 is augmented and released by recipient conditioning to promote Type 1 alloimmunity and lethal acute…
  • 2016 American Transplant Congress

    Novel Function of CD4+ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.

    J. Wedel,1,2 S. Bruneau,1,2 K. Liu,1,2 N. Kochupurakkal,1,2 M. Laplante,3 D. Briscoe.1,2

    1Division of Nephrology, Boston Children's Hospital, Boston, MA; 2Transplant Research Program, Harvard Medical School, Boston, MA; 3CRIUCPQ, Université Laval, Quebec, Canada.

    DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…
  • 2016 American Transplant Congress

    Obesity Is Associated with Increased Risk of ESRD Among Living Kidney Donors.

    J. Locke,1 C. Lewis,1 R. Reed,1 V. Kumar,1 D. Sawinski,2 A. Massie,3 P. MacLennan,1 R. Mannon,1 R. Gaston,1 D. Segev.3

    1School of Medicine, University of Alabama at Birmingham, Birmingham, AL; 2School of Medicine, University of Pennsylvania, Philadelphia, PA; 3School of Medicine, Johns Hopkins University, Baltimore, MD.

    Background: Living kidney donor (LKD) demographics have changed, and transplant centers have relaxed selection criteria to include LKDs who are obese. Prior studies of LKDs…
  • 2016 American Transplant Congress

    Kidney Donor Profile Index Trend Analyses.

    D. Vikraman, K. Ravindra, S. Sanoff, W. Irish, U. Patel, D. Sudan.

    Surgery, Duke University Medical Center, Durham, NC.

    IntroductionIn spite of improved outcomes associated with the usage of extended criteria donor (ECD) kidneys, the number of kidney transplants (KT) using this donor population…
  • 2016 American Transplant Congress

    Anti-IL6R Therapy (Tocilizumab) Improves Long-Term Patient & Graft Survival in Patients with Chronic Antibody-Mediated Rejection and Transplant Glomerulopathy.

    J. Choi, A. Vo, M. Haas, D. Puliyanda, S. Louie, A. Peng, J. Kahwaji, R. Villicana, I. Kim, J. Mirocha, S. Jordan.

    Comprehensive Transplantation Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction:Extending the functionality of renal allografts is an essential goal of transplant medicine. HS patients (pts) are at increased risk for chronic ABMR (CABMR) due…
  • 2016 American Transplant Congress

    Impact of Pretransplant Non-Donor-Specific HLA Immunization: Mainly Class 1 Immunization Leads to Poor Immunologic Outcome and Graft Loss.

    O. Staeck, F. Halleck, A. Staeck, L. Lehner, M. Duerr, E. Schrezenmeier, K. Budde, D. Khadzhynov.

    Nephrology, Charite, Berlin, Germany.

    Background Anti-HLA immunization measured as Panel Reactive Antibodies (PRA) is known to have a negative impact on patient and graft survival. The influence of pre-transplant…
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