ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Prior Infection or Colonization with Carbapenem-Resistant Enterobacteriaceae Is Not an Absolute Contraindication for Solid Organ Transplantation.

    S. Huprikar,1 L. Casner,1 S. Pouch,2 M. Pinheiro Freire,3 R. Madan,4 E. Kwak,5 M. Satlin,6 P. Hartman,7 L. Pisney,8 P. Henrique Mourão,9 R. La Hoz,10 G. Patel.1

    1Mount Sinai, New York; 2Ohio State, Columbus; 3Sao Paulo University, Sao Paulo, Brazil; 4Albert Einstein, Bronx; 5University of Pittsburgh, Pittsburgh; 6Cornell, New York; 7Henry Ford Health System, Detroit; 8University of Colorado, Denver; 9Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; 10UT Southwestern, Dallas.

    BackgroundCarbapenem-resistant Enterobacteriaceae (CRE) infection is associated with poor outcomes after solid organ transplantation (SOT). The significance of CRE colonization or infection prior to SOT is…
  • 2016 American Transplant Congress

    Probability, Risk Factors, and Long-Term Outcomes of Biliary Complications After Hepatic Artery Thrombosis in Adult Liver Transplant Recipients: 20 Years Experience from a Single Center.

    M. Fujiki, K. Hashimoto, T. Diago, C. Quintini, F. Aucejo, D. Kelly, B. Eghtesad, J. Fung, C. Miller.

    General Surgery, Cleveland Clinic, Cleveland, OH.

    Hepatic artery thrombosis (HAT) after liver transplantation (LT) is a devastating complication associated with ischemic biliary cholangiopathy (IBC) that can occur even after successful revascularization.…
  • 2016 American Transplant Congress

    DNA Methylation Patterns and Association with Graft Injury Severity Post Liver Transplantation.

    R. Gehrau, S. Bontha, V. Mas, D. Maluf.

    UVA, Charlottesville.

    Background: Epigenetics modifications in the graft may influence injury severity and function post liver transplantation (LT). This study aimed to interrogate the effect of different…
  • 2016 American Transplant Congress

    Long-Term Outcomes of ATG versus IL-2 Receptor Antagonist in Low Risk Kidney Transplant Recipients: Donor Factors.

    F. Al Ammary, S. Bae, A. Massie, N. Desai, N. Dagher, E. Kraus, A. Wiseman, D. Segev.

    JHU, Baltimore; CU, Denver.

    Controversy exists regarding the optimal choice of induction therapy in low-risk kidney transplant (KT) recipients. Current guidelines specify induction choices in KT based on recipient…
  • 2016 American Transplant Congress

    Investigating Geographic Variation in the Number of Deceased Donor Transplants Performed in the U.S.

    R. Carrico, D. Stewart, R. Ehrensberger, B. Shepard, D. Klassen.

    UNOS, Richmond, VA.

    Background: In 2014 the number of deceased donor transplants (DDT) increased greatly compared to the period from 2005 to 2013 when there were minimal changes…
  • 2016 American Transplant Congress

    Efficacy and Safety of Direct Antiviral Agents (DAA)-Based Therapies for Hepatitis C Virus (HCV) Infection in Kidney Transplant (KT) Recipients.

    M. Fernandez Ruiz,1 A. García Santiago,2 N. Polanco Fernandez,2 R. Muñoz,3 A. Hernandez,2 E. González Monte,2 V. Mercado,2 I. Fernández,3 J. Aguado,1 M. Praga,2 A. Andrés.2

    1Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Madrid, Spain; 2Nephrology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 3Gastroenterology, Hospital Universitario “12 de Octubre”, Madrid, Spain.

    Background: The use of interferon-based regimens for HCV infection in KT recipients is limited due to the increased risk of acute graft rejection (AR), poor…
  • 2016 American Transplant Congress

    Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.

    N. Chun,1 M. Zhang,2 R. Fairchild,3 P. Heeger.1

    1Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; 2Anesthesia, SUNY Downstate, NY, NY; 3Immunology, Cleveland Clinic, Cleveland, OH.

    Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…
  • 2016 American Transplant Congress

    Acute Rejection in Non-Human Primates Treated with Belatacept Is Mediated by a Unique CD8 Memory Subset.

    D. Mathews,1 W. Wakwe,1 M. Lowe,1 C. Breeden,1 F. Leopardi,1 A. Farris,1 M. Song,1 E. Strobert,2 J. Jenkins,2 C. Larsen,1 R. Townsend,3 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2Yerkes National Primate Research Center, Atlanta, GA; 3Bristol Myers-Squibb Pharmaceutical Research Institute, Princeton, NJ.

    Belatacept is a high affinity version of the fusion protein CTLA4-Ig that blocks CD28 mediated T cell costimulation, providing a more targeted/less toxic form of…
  • 2016 American Transplant Congress

    Risk of ESRD in Potential HIV+ Live Kidney Donors.

    A. Muzaale,1 L. Kucirka,1 A. Massie,1 C. Durand,1 J. Locke,2 G. Lucas,1 D. Segev.1

    1Johns Hopkins University, Baltimore; 2University of Alabama, Birmingham.

    The HOPE Act allows HIV+ individuals to be live kidney donors; however, candidacy for donation is poorly understood given the potential additional risk of ESRD…
  • 2016 American Transplant Congress

    DAAs Rapidly Clear HCV Viremia in Recipients of HCV+ Donor Kidneys.

    D. Sawinski, R. Bloom, N. Patel.

    Renal Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia, PA.

    Purpose: Direct acting antivirals (DAAs) have revolutionized the treatment of hepatitis C (HCV) in both general and liver transplant populations. However, data in kidney transplant…
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