ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Risk of ESRD in Potential HIV+ Live Kidney Donors.

A. Muzaale,1 L. Kucirka,1 A. Massie,1 C. Durand,1 J. Locke,2 G. Lucas,1 D. Segev.1

1Johns Hopkins University, Baltimore
2University of Alabama, Birmingham.

Meeting: 2016 American Transplant Congress

Abstract number: 51

Keywords: Donation, Risk factors

Session Information

Date: Sunday, June 12, 2016

Session Name: Concurrent Session: Living Kidney Donation: Risk Factors for Adverse Long term Outcome

Session Time: 2:30pm-4:00pm

 Presentation Time: 3:06pm-3:18pm

Location: Veterans Auditorium

Related Abstracts
  • Risk of Cause-Specific ESRD in Live Kidney Donors
  • Long-Term Risk of ESRD Attributable to Live Kidney Donation: Matching with Healthy Non-Donors

The HOPE Act allows HIV+ individuals to be live kidney donors; however, candidacy for donation is poorly understood given the potential additional risk of ESRD associated with HIV. Our goal was to quantify this risk in otherwise healthy HIV+ potential donors.

Methods: A cohort of 36,364 HIV+ participants of the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) and a cohort of 12,460 HIV- participants of the Third National Health and Nutrition Examination Survey (NHANES III) were linked to USRDS to ascertain cases of ESRD. The median follow-up was 5 years (interquartile range [IQR], 3-8) for the HIV+ cohort and 14 years (IQR, 12-15) for the HIV- cohort. We used risk associations from multivariable Cox proportional hazards regression to derive cumulative incidence estimates for selected HIV+ scenarios (no history of diabetes, hypertension, injection drug use, or HCV co-infection) and compared these cumulative incidence estimates with those for similarly selected HIV- scenarios.

Results: For a 40-year white HIV+ individual with eGFR of 90 ml/min, viral load <200 copies/mL, CD4+ count 500 cells/mL, the 9-year cumulative incidence of ESRD was only slightly increased compared with the HIV- counterpart: 4.0 versus 1.1 per 10,000 among white females, 4.5 versus 3.4 per 10,000 among white males. This difference was more pronounced among black individuals, although still the absolute risk was quite low: 19.0 versus 4.2 per 10,000 among black females, and 23.1 versus 6.0 per 10,000 among black males.

Conclusions: HIV+ individuals with no comorbidities and well-controlled disease may be considered low-risk live kidney donor candidates. For each category of race and sex, the additional risk of ESRD due to HIV was quite low; for perspective, this increased risk was comparable to the additional risk of ESRD in HIV- potential donors due to cigarette smoking.

CITATION INFORMATION: Muzaale A, Kucirka L, Massie A, Durand C, Locke J, Lucas G, Segev D. Risk of ESRD in Potential HIV+ Live Kidney Donors. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Muzaale A, Kucirka L, Massie A, Durand C, Locke J, Lucas G, Segev D. Risk of ESRD in Potential HIV+ Live Kidney Donors. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/risk-of-esrd-in-potential-hiv-live-kidney-donors/. Accessed February 28, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.