Am J Transplant, Volume 16, Suppl 3 Archives - Page 133 of 180 - ATC Abstracts

2016 American Transplant Congress
Strategies to Prevent Ischemic Cholangiopathy After Donation After Circulatory Death Donor Liver Transplantation.
C. Kubal,¹ R. Mangus,¹ J. Fridell,¹ B. Ekser,¹ N. Rush,² R. Saxena,² J. Tector.¹
¹Department of Surgery, Indiana University School of Medicine, Indianapolis, IN; ²Department of Pathology, Indiana University School of Medicine, Indianapolis, IN.
Background: Donation after circulatory death (DCD) donor pool remains underutilized for liver transplantation (LT). We describe optimizing the “modifiable risk factors”, such as CIT, recipient…
2016 American Transplant Congress
Long-Term Liver Function of Deceased Liver Transplantation Using Hepatitis B Surface Antigen Positive Grafts.
W.-C. Lee,¹ Y.-C. Wang,¹ C.-H. Cheng,¹ T.-H. Wu,¹ C.-F. Lee,¹ R.-S. Soong,¹ T.-J. Wu,¹ H.-S. Chou,¹ K.-M. Chan,¹ C.-S. Lee.²
¹Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Taoyuan, Taiwan; ²Hepatology, Chang-Gung Memorial Hospital, Taoyuan, Taiwan.
Background: Deceased donors with hepatitis B [HBs Ag(+)] were not recommended to recover the livers for liver transplantation. However, in endemic area of hepatitis B…
2016 American Transplant Congress
Hyponatremia in Early Post Lung Transplantation Predicts Patient and Hospital Outcomes.
E. Tantisattamo,¹ A. Chokechanachaisakul,² O. Traitanon,³ A. Shetty,² B. Ho,² J. Friedewald,² S. Bhorade,² A. Haynes,² A. Nieland,² L. Gallon.²
¹Oakland University William Beaumont School of Medicine, Royal Oak, MI; ²Northwestern University Feinberg School of Medicine, Chicago, IL; ³Department of Medicine-Nephrology, Thammasart University Hospital, Pathumthani, Thailand.
Background: Outcomes of hyponatremia during immediate post-lung transplantation are unknown. We aim to identify the incidence of postoperative hyponatremia and its outcomes.Methods: All lung transplantations…
2016 American Transplant Congress
Prospective Single Antigen Bead Epitope-Based Clustering for Early Detection of Antibody Mediated Rejection.
A. Lichvar, S. Tremblay, P. Brailey, A. Girnita, R. Alloway, E. Woodle.
U of Cincinnati, Cincinnati.
Purpose:Epitope-based groups of HLA single antigen beads (SAB) often demonstrate clustering in patients with donor specific antibodies (DSA). Coordinated Mean Florescent Intensity (MFI) increases of…
2016 American Transplant Congress
Baseline Donor Specific Antibody (DSA) More Predictive of Chronic Antibody Mediated Rejection (CAMR) Than the Change in DSA Over Time.
D. Mitema,¹ W. Cheungpasitporn,¹ M. Stegall,¹ F. Cosio,¹ M. Gandhi,² C. Schinstock.¹
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Division of Transfusion Medicine, Mayo Clinic, Rochester, MN.
Introduction: Although therapies are available to at least temporarily reduce DSA, the change in DSA naturally post-transplant remains unknown. We aim to study the serial…
2016 American Transplant Congress
Alemtuzumab Induction Therapy in Elderly Kidney Transplant Recipients.
I. Yakubu,¹ B. Masters,¹ B. Ravichandran,¹ T. Sparkes,¹ M. Moss,¹ F. Rasetto,¹ S. Jonchhe,¹ B. Thomas,² N. Costa,² D. Leeser,² S. Bartlett,² A. Haririan.²
¹Pharmacy, University of Maryland Medical Center, Baltimore; ²University of Maryland Medical Center, Baltimore.
Background: In descriptive studies, alemtuzumab has been associated with an escalating risk of death and graft loss in elderly (≥65 years) kidney transplant recipients. However,…
2016 American Transplant Congress
Anti-Thymocyte Globulin Induction Does Not Increase the Risk of Thrombotic Events in Kidney Transplantation: A Matched Case-Control Study.
J. Iuppa,¹ M. Dokus,² E. Venniro,³ A. Patel,² A. Danzig,⁴ J. Hahn,¹ R. Kashyap,² M. Orloff,² J. Taylor.³
¹Department of Pharmacy, University of Rochester, Rochester, NY; ²Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, University of Rochester, Rochester, NY; ³Department of Medicine, Division of Nephrology, University of Rochester, Rochester, NY; ⁴School of Medicine and Dentistry, University of Rochester, Rochester, NY.
Background: Anti-thymocyte globulin (ATG) is the most commonly used induction agent in kidney transplantation (KTx). To date, case reports and in vitro analyses have suggested…
2016 American Transplant Congress
LACE Index Risk Assessment Tool Predicts Liver Transplant Readmissions.
A. Masoumi,¹ R. Barth,² J. LaMattina,² D. Bruno,² L. Hebert,¹ N. Schluterman,³ S. Hanish.²
¹University of Maryland Medical Center, Baltimore, MD; ²Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; ³Department of Epidemiology, University of Maryland School of Public Health, Baltimore, MD.
Background:One-fifth of Medicare patients are readmitted to the hospital an annual cost of $17.4 billion. The LACE Index (Length of stay, Acuity of the admission,…
2016 American Transplant Congress
Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.
S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase1 (TIMP-1) is the…
2016 American Transplant Congress
Histone Deacetylase-2 Gene Deletion in Mice Mitigates Liver Ischemia/Reperfusion Injury.
D. Murken,¹ D. Aufhauser Jr,¹ Z. Wang,² G. Ge,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…