Date: Tuesday, June 14, 2016
Session Name: Poster Session D: Psychosocial and Treatment Adherence
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background. We have assessed the prevalence of medication nonadherence after kidney transplantation and investigated its psychosocial correlates, as a part of the PRIMA study, an ongoing prospective study using mobile internet application to improve adherence.
Methods. Renal allograft recipients aged 15-70 years old, who were at least 12 month post-transplant were enrolled in the PRIMA study. Initially, self-reported medication adherence was assessed with 4-item Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS-interview): total score 0–20 (0, adherence; > 1, nonadherence). Participants also completed the Korean version of the Hospital Anxiety and Depression Scale (HADS) and the 10–item Big Five Inventory (BFI-10-K) for the self-evaluation of anxiety / depression, and personality traits. Relationship between self-reported adherence and psychosocial factors as well as demographic factors was evaluated.
Results. Among 137 participants, 73 (53.2%) were classified as nonadherent according to the BAASIS-interview. Smoking, longer time since transplantation (≥ 2 years), transplantation from a deceased donor or living donor other than spouse or 1st degree relative, depression (HAD-D; depression subscale ≥ 6), and anxiety (HAD-A; anxiety subscale ≥ 8) were factors associated with self-reported medication nonadherence in univariate analysis. Longer time since transplantation depression (OR 2.57, 95% CI 1.18-5.60, P=0.018), depression (OR 2.28, 95% CI 1.03-5.01, P=0.043) and transplantation from donors other than spouse or 1st degree relative (OR 4.02, 95% CI 1.71-9.42, P=0.001) were also significantly associated with nonadherence in multivariate analysis.
Conclusion. Duration since TPL, depression, and the recipient's relationship with the donor showed significant association with self-reported nonadherence. Such correlates associated with adherence may be a valuable potential target to be considered in designing future studies aimed to improve medication adherence after kidney transplantation.
CITATION INFORMATION: Han A, Choi C, Kim S.-Y, Cho S, Cho M.-J, Lee C, Ahn S, Min S.-I, Min S.-K, Jung I, Kim S, Park M, Ha J. Psychosocial Factors Associated with Medication Adherence Based on Self Reports in Kidney Allograft Recipients: Baseline Findings from the PRIMA (ImPRoving Adherence to Immunosuppressive Therapy by Mobile Internet Application) Study. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Han A, Choi C, Kim S-Y, Cho S, Cho M-J, Lee C, Ahn S, Min S-I, Min S-K, Jung I, Kim S, Park M, Ha J. Psychosocial Factors Associated with Medication Adherence Based on Self Reports in Kidney Allograft Recipients: Baseline Findings from the PRIMA (ImPRoving Adherence to Immunosuppressive Therapy by Mobile Internet Application) Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/psychosocial-factors-associated-with-medication-adherence-based-on-self-reports-in-kidney-allograft-recipients-baseline-findings-from-the-prima-improving-adherence-to-immunosuppressive-therapy-by-mo/. Accessed November 19, 2019.
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