Am J Transplant, Volume 16, Suppl 3 Archives - Page 117 of 180 - ATC Abstracts

2016 American Transplant Congress
Cytokine Storm in Acute Post-Hepatectmy Phase Associates with Liver Injury and Impaired Liver Regeneration.
Y. Xu,^1,2 N. Navarro-Alvarez,¹ J. Dong,² J. Markmann,¹ H. Yeh.¹
¹Transplantation Division, Massachusetts General Hospital, Boston, MA; ²Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.
Background Posthepatectomy liver failure and its transplant counterpart, small-for-size syndrome, remain poorly understood. Large increases in IL-6 are associated with poor allograft function and IL-6…
2016 American Transplant Congress
Quality of Postoperative Pain Care in Living Liver Donors.
M. Mandell,¹ A. Smith,^2,6 D. Gordon,³ S. Holtzman,⁴ M. Dew,⁵ T. Howell,⁶ A. DiMartini,⁵ Z. Butt,⁸ M. Simpson,⁷ C. Freise,⁹ S. McCluskey,¹⁰ R. Fisher,¹¹ J. Guaerra,¹² K. Olthoff,¹³ E. Pomfret.⁷
¹U of Colorado, Denver; ²Arbor Research Collaborative for Health, Ann Arbor; ³U of Washington, Seattle; ⁴U of British Columbia, Okanagan, Canada; ⁵U of Pittsburgh, Pittsburgh; ⁶U of Michigan, Ann Arbor; ⁷Lahey, Burlington; ⁸Northwestern U, Chicago; ⁹U of California at San Francisco, San Francisco; ¹⁰U of Toronto, Toronto, Canada; ¹¹Virginia Commonwealth U, Richmond; ¹²Columbia U, New York; ¹³U of Pennsylvania, Philadelphia.
Background: Postoperative pain (POP) is the strongest predictor of chronic pain syndromes (Katz and Seltzer, Expert Rev Neurother 2009), however little is known about POP…
2016 American Transplant Congress
Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.
S. Yilmaz,¹ D. Shaffer,² Y. Qazi,³ F. Shihab,⁴ K. McCague,⁵ D. Patel,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Southern California, Los Angeles, CA; ⁴University of Utah, Salt Lake City, UT; ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁶University of California San Francisco, San Francisco, CA.
Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
2016 American Transplant Congress
Chronic Infection by Hepatitis C Virus and the Development of Transplant Glomerulopathy.
D. Regidor,¹ S. Alexandru,⁵ M. Martínez,³ N. Polanco,⁴ E. González,⁴ A. Serrano,² J. Morales.⁴
¹Nephrology, H.Virgen de la Salud, Toledo, Spain; ²Immunology, Instituto de Investigación H. Doce de Octubre, Madrid, Spain; ³Pathology, H.Doce de Octubre, Madrid, Spain; ⁴Nephrology, H.Doce de Octubre, Madrid, Spain; ⁵Nephrology, H.Rey Juan Carlos, Madrid, Spain.
OBJETIVE: To demonstrate that chronic infection with the hepatitis C virus (HCV) is a risk factor for the development of transplant glomerulopathy in a large…
2016 American Transplant Congress
Early Posttransplant Complications Following Abo-Incompatible Kidney Transplantation.
L. Rostaing,^1,2,3 A. Allal,¹ H. Naciri Benami,¹ Z. Abdulrahman,¹ L. Esposito,¹ F. Sallusto,¹ N. Doumerc,¹ X. Game,¹ B. Debiol,¹ N. Congy,¹ N. Kamar.^1,3,4
¹Néphrologie et Transplantation d'Organes, CHU Rangueil, Toulouse, France; ²INSERM U 563, CHU Purpan, Toulouse, France; ³Faculté de Médecine de Rangueil, Université Toulouse III Paul Sabatier, Toulouse, France; ⁴INSERM U1043 CNRS UMR 5282, CHU Purpan, Toulouse, France.
Introduction: Many studies or registries particularly in Japan, but also in Western Europe, have shown that long-term results from ABO-incompatible (ABOi) living-kidney transplantation are as…
2016 American Transplant Congress
Watch Out for the Guy with the Low EPTS Score: Nonadherence and Kidney Allograft Failure.
A. Liu, K. Balabhadrapatruni, J. Augustine.
Medicine, University Hospitals Case Medical School, Cleveland, OH.
Background: Nonadherence is a known cause of rejection and kidney allograft failure. Our aim was to define risk factors for allograft loss related to nonadherence.…
2016 American Transplant Congress
Surgical Techniques in Modified Multiorgan Transplantation.
W. Ju, J. Lin, J. Zhou, M. Chen, A. Yang, D. Wang, Y. Ma, Z. Guo, M. Han, X. Wang, X. Zhu, X. He.
Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Objective: Investigate the clinical efficacy of combined en-bloc liver-pancreas transplantation in patients with end stage liver disease and diabetes.Method: The clinical data of 19 cases…
2016 American Transplant Congress
Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.
N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Costimulation blockade prolongs graft survival but does not induce tolerance in primates, and mechanisms of rejection are incompletely understood. Here we evaluate changes in…
2016 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2).
E. Yin,^1,2 M. Uchiyama,^1,3 X. Jin,^1,4 T. Shimokawa,³ H. Yagita,⁵ M. Niimi.¹
¹Surgery, Teikyo University, Tokyo, Japan; ²Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Thoracic Surgery, The 3rd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Immunology, Juntendo University Hospital, Tokyo, Japan.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2016 American Transplant Congress
Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4⁺CD25⁺FoxP3⁺ Treg Cells.
K. Woodward,¹ H. Zhao,¹ H. Shirwan,¹ F. Wang,¹ M. Graham,² B. Hering,² E. Yolcu.¹
¹Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY; ²Schulze Diabetes Institute and Department of Surgery, University of Minnesota, Minneapolis, MN.
Introduction: We have shown that porcine islets engineered to transiently display SA-FasL protein on their surface establish tolerance in mice following transplantation under the kidney…