Am J Transplant, Volume 16, Suppl 3 Archives - Page 112 of 180 - ATC Abstracts

2016 American Transplant Congress
Graft Survival of Steroid-Avoidance Protocols in Pediatric Kidney Transplantation[mdash]A Propensity Score Analysis.
E. Nehus,¹ Y. Wang,² B. Lu,³ C. Liu,² M. Macaluso,² M.-O. Kim.²
¹Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ³Division of Biostatistics, The Ohio State University, Columbus, OH.
Purpose: This study investigated whether steroid avoidance-protocols adversely influence allograft survival among pediatric kidney transplant recipients at high levels of immunologic risk.Methods: A retrospective cohort…
2016 American Transplant Congress
Lower Renal Graft Function and Accelerated Fibrosis in HIV-Infected Transplant Recipients with Previous HIVAN Compared to Non HIVAN HIV-Positive Transplant Recipients.
M.-N. Peraldi,¹ H. Ayari,¹ M. Burbach,¹ C. Randoux,² E. Pillebout,¹ N. De Castro,³ J.-M. Molina,³ D. Glotz.¹
¹Nephrologie et Transplantation, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France; ²Néphrologie, Hôpital Bichat et Université Paris-Diderot, Paris, France; ³Service de Maladies Infectieuses, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France.
Several studies reported reduced renal allograft survival rates among HIV-infected transplant recipients. Few data focus on histological lesions and their progression in renal grafts from…
2016 American Transplant Congress
Survival Advantage with Older Live Donor Compared to Standard Criteria Deceased Donor Kidney Transplantation in Older Recipients.
P. Abrams, M. Cooper, J. Verbesey, R. Ghasemian, M. Grafals, A. Gilbert, J. Moore, J. Fenton, C. Cannon, J. Rapisurra, B. Javaid.
MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC.
Objective: Analyze post-transplant outcomes in older recipients of kidney transplants from older live donors compared to older recipients of standard criteria deceased donor kidney transplants.Methods:…
2016 American Transplant Congress
HLA Antibody in Transplant Recipients During Transition from Paediatrics.
S. Kaki,¹ A. Lunn,² J. Goodwin,³ T. Key,³ W. McKane.¹
¹Renal, Sheffield Kidney Institute, Sheffield, United Kingdom; ²Renal, Queens Medical Centre, Sheffield, United Kingdom; ³Histocompatibility and Immunogenetics, National Health Service blood and transplantation, Sheffield, United Kingdom.
Objective:Adolescent transplant recipients in transition from paediatric to adult units are known to be at high risk of graft failure. Detection of HLA antibody is…
2016 American Transplant Congress
Post-Transplant T-Cell Alloreactive Perturbation Precedes the Advent of Humoral Immunity in Kidney Transplant Patients.
E. Crespo,¹ S. Luque,¹ J. Cruzado,² E. Melilli,² J. Grinyo,² M. Lucia,¹ O. Bestard.²
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical inflammation in kidney allografts is associated with worse outcome and the activation of humoral alloimmunity. Surveillance allograft biopsies are an accurate tool to diagnose…
2016 American Transplant Congress
Elevated Intragraft Expression of Innate Immunity and Cell Death-Related Markers Characterizes Deceased Donor Conditions and Is a Risk Factor for Adverse Graft Outcome.
M. Eikmans,¹ J. Yang,¹ G. Haasnoot,¹ C. van Kooten,² M. Mallat,² H. de Fijter,² I. Bajema,³ F. Claas.¹
¹Immunohematology, LUMC, Leiden, Netherlands; ²Nephrology, LUMC, Leiden, Netherlands; ³Pathology, LUMC, Leiden, Netherlands.
Background: The innate immune response is increasingly being recognized in allograft injury after kidney transplantation. We aimed to establish the relationship of innate immune gene…
2016 American Transplant Congress
Informing Informed Consent for High KDPI Kidneys.
A. Nishio Lucar, D. Keith, G. Vranic.
Medicine, University of Virginia, Charlottesville, VA.
The standard approach to informed consent for high KDPI (KDPI 86-100%) deceased donor kidneys (DDK) relies on anticipated graft half-life and may not provide candidates…
2016 American Transplant Congress
Pulmonary Hypertension in Renal Transplant Candidates: A Systematic Review and Meta-Analysis of the Available Evidence.
A. Moza,¹ A. Khan,² R. Prashar,³ S. Khan,¹ S. Khouri,¹ S. Vetteth,¹ D. Malhotra,¹ M. Rees,¹ G. Moukarbel,¹ J. Ortiz.¹
¹Cardiovascular Medicine, University of Toledo Medical Center, Toledo, OH; ²Cardiovascular Medicine, University of Louisville, Louisville, KY; ³Nephrology and Transplantation, Henry Ford Medical Center, Detroit, MI.
Background: Pulmonary hypertension (PHT) is common in patients with end stage renal disease (ESRD). Moderate to severe PHT is a strong independent predictor of mortality…
2016 American Transplant Congress
Local Infusion of MyD88 Inhibitor Inhibits Ischemia-Reperfusion Kidney Injury.
H. Cho,^1,3 J. Lee,^1,4 H. Kim,^1,2 Y. Han,² B. Kwon,^1,2 S. Park,^1,3 K. Park.⁴
¹Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; ³Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.
We have previously shown that tubular epithelial cells play a central role in regulating ischemia-reperfusion kidney injury (K-IRI). Tubular epithelial cells damaged by hypoxic insult…
2016 American Transplant Congress
Recall Alloantibody Production Is Driven by CD138⁺ Cells Proliferating in the Spleens: An Indication for Long-Lived Plasma Cell Activities and Potential Therapeutic Target.
I. Kim, N.-N. Chai, A. Klein, S. Jordan, G. Wu.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Donor-specific antibodies (DSA) generated in recall responses are produced by long-lived plasma cells (L-PC) residing in the bone marrows (BM). Mechanisms of L-PC activation,…