2016 American Transplant Congress
Role of Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Osteomyocutaneous Allotransplantation Under Combined Costimulation Blockade.
Background: The role of regulatory T cells (Tregs) in allograft tolerance has been studied using various transplant models, but the mechanism in vascularized composite allotransplantation…2016 American Transplant Congress
Fecal Microbiota Transplant Results in Durable Changes to Host Microbiota That Correlate with Allograft Outcome.
CVID and IGS, University of Maryland School of Medicine, Baltimore, MD.
Hypothesis: We previously presented highly significant differences in the bacterial community structures of human renal allograft recipients over time. Likewise, murine normal, colitic, and pregnant…2016 American Transplant Congress
Ameliorating Progression of Allograft Vasculopathy by Targeting the T Follicular Helper Cell Subset.
Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
BACKGROUNDDevelopment of long-lived alloantibody is closely linked with chronic rejection and graft failure. We examined in a murine model of antibody-mediated rejection (AMR) if targeting…2016 American Transplant Congress
The Survival Benefit of Pancreas and/or Kidney Transplantation for Patients with Type 1 Diabetes.
SUNY Upstate Medical University, Syracuse, NY.
Introduction: Deceased donor transplantation (tx) has provided an enormous survival benefit for patients with end-stage organ failure. An analysis of the survival benefit for type…2016 American Transplant Congress
NK Cells Play a Critical Role in Mediating Inflammation and Graft Failure During Antibody-Mediated Rejection of Kidney Allografts.
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…2016 American Transplant Congress
Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.
1Transplant Research Program, Boston Children's Hospital, Boston; 2MGH, Boston.
Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…2016 American Transplant Congress
Impact of Early Calcineurin Inhibitor Withdrawal on Renal Function and Urinary Protein Excretion: 24 Month Analyses of the ELEVATE Study.
Background: Proteinuria is a biomarker which helps in predicting graft outcomes in kidney transplant recipients (KTxRs). The ELEVATE study was designed to determine whether an…2016 American Transplant Congress
Predictors of Early Rejection and Allograft Failure in Pediatric Kidney Transplantation: Impact of Histology and Behavior.
University of Alabama at Birmingham School of Medicine, Birmingham.
Background: Early inflammatory events that lead to allograft dysfunction are often missed by creatinine-based estimates in children. Surveillance biopsies can detect early allograft dysfunction due…2016 American Transplant Congress
Have We Gone Too Far Defining Performance Outliers? One-Third of Kidney Transplant Programs Now Identified for Low Performance within Three Years.
Transplant center report cards developed by SRTR are publicly available and utilized for regulatory oversight and insurance contracting. There are significant associations of performance oversight…2016 American Transplant Congress
Clinical Rejection-Risk Assessment with Allospecific CD154+T-Cytotoxic Memory Cells (CD154+TcM) After Pediatric Liver or Intestine Transplantation (LTx, ITx).
Surgery, Children's Hosp of Pgh of UPMC & Univ of Pittsburgh, Pittsburgh, PA.
Background: In preclinical evaluation, CD154+TcM predict acute cellular rejection after LTx or ITx with sensitivity/specificity of 80%. Purpose/Methods: To summarize test indications and performance during…
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