Am J Transplant, Volume 16, Suppl 3 Archives - ATC Abstracts

2016 American Transplant Congress
A Virtual Crossmatch Algorithm That Mimics the Sensitivity of Flow Cytometric Crossmatch.
P. Rao, D. Deo, C. Rhodes, D. King, P. Bowe, J. Napoleon, I. Okere.
NJ Sharing Network, New Providence, NJ.
Aim: The new Kidney Allocation System has increased requests for virtual crossmatches (VXM) to predict the possibility of a negative donor specific crossmatch. This study…
2016 American Transplant Congress
Blindspots in HLA Antibody Testing: Recognition Is First Step to Nirvana.
A. Kher, P. Dorwal, V. Kher.
Medanta-The Medicity, Gurgaon, Haryana, India.
This study was conducted to assess population frequency of alleles missing from single antigen bead (SAB) panels & frequency of allelic antibodies (Abs).Methods: All positive…
2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
A. Haririan,¹ M. Chaudhry,² J. Papadimitriou,² N. Costa,¹ B. Thomas,¹ M. Mavanur,¹ R. Ugarte,¹ C. Cangro,¹ C. Drachenberg.²
¹Dept of Medicine, Unniversity of Maryland, Baltimore, MD; ²Dept of Pathology, University of Maryland, Baltimore, MD.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
2016 American Transplant Congress
Molecular Profiles of Renal Allograft Rejection.
Z. Hajjiri, P. Finn, D. Perkins.
Internal Medicine/Renal Medicine, University of Illinois at Chicago, Chicago, Il.
Introduction: The gold standard for the diagnosis of allograft rejection is the Banff Classification, yet it shows substantial variability among pathologists. Using molecular signatures of…
2016 American Transplant Congress
Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.
B. Schroppel,¹ P. Heeger,² I. Hall,³ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹University Hospital, Ulm, Germany; ²Mount Sinai School of Medicine, New York; ³Program of Applied Translational Research, Yale University School of Medicine, New Haven; ⁴Wayne State University, Detroit; ⁵Barnabas Health, Livingston; ⁶University of Pennsylvania, Philadelphia.
Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…
2016 American Transplant Congress
Survival Benefit of High-KDPI Kidneys Among Obese Transplant Candidates.
M. Bowring, A. Massie, X. Luo, D. Segev.
JHU, Baltimore.
Obese patients have less access to kidney transplantation; use of high-KDPI kidneys could help expand access in this population, but the cumulative effect of obesity…
2016 American Transplant Congress
VO_2peak Outperforms Troponin T for Risk Prediction of Cardiovascular Disease and All-Cause Mortality in Patients with End Stage Renal Disease Being Evaluated for Kidney Transplant.
H. Chakkera,¹ C. Lee,² J. Dickinson,^1,2 B. Kaplan,^1,2 I. Qaqish,¹ S. Behmen,¹ R. Heilman,¹ H. Khamash,¹ J. Huskey,¹ S. Nair,¹ R. Scott,¹ D. Steidley,¹ M. Temkit,¹ S. Angadi.^1,2
¹Mayo Clinic, Arizona; ²Arizona State University, AZ.
Background: Cardiovascular disease (CVD) is a major health care concern in end-stage renal disease (ESRD). Peak oxygen uptake (VO2peak) is a strong predictor of CVD…
2016 American Transplant Congress
Adding Anti-Inflammatory Agents During Normothermic Ex-Vivo Liver Perfusion Improves the Preservation of Pig Liver Grafts Before Transplantation.
N. Goldaracena, E. Juan, K. Moritz, V. Spetzler, A. Barbas, D. Grant, M. Selzner.
Multi Organ Transplant Program, Toronto General Hospital, Toronto, Canada.
Introduction: Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemic injury. We investigated if protective effects of NEVLP can be further…
2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴
¹Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; ²Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; ³Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; ⁴Pathology, Toronto General Hospital, Toronto, ON, Canada.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…
2016 American Transplant Congress
Resveratrol Effectively Suppress Th17 Associated Allo-Immune Responses by the Modulation of AMPK/mTOR Pathway.
B. Chung, K. Doh, J.-W. Min, K. Kim, B.-M. Kim, M.-L. Cho, C. Yang.
Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
The aim of this study is to investigate the effect of resveratrol on Th17 allo-immune responses under tacrolimus (Tac)-based immune suppression. First, we investigated the…

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