Session Name: Poster Session D: Diagnostics/Biomarkers Session II
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
UBio might be valuable in determining the etiology of renal dysfunction in LT candidates.Aim: Correlate UBio with pre-LT kidney biopsy and post-LT kidney function.Methods:78 LT candidates with renal dysfunction (iothalamate GFR<40ml/min or proteinuria>500mg/d) had pre-LT UBio. 28 patients had either pre-LT (n=20) or intra-operative (n=8) kidney biopsy. 58 patients received LT. Serum Cr and 24-hr urine Cr clearance were measured post-LT. UBio were correlated with the % interstitial fibrosis (IF) and % glomerulosclerosis (GS) on kidney biopsy and post-LT renal function.Results: Patients' demographics and biopsy findings are in Table 1
|Median serum Cr||1.8 (0.6,3.3)|
|Median iGFR||29 (9,127)|
|Kidney Biopsy findings||N=28|
|Median %IF||5 (0,40)|
|Median %GS||22 (0,77)|
Correlations of UBio with biopsy findings are in Table 2
|Urinary biomarker||Correlation with %IF||P||Correlation with %GS||P|
|Neutrophil gelatinase-associated lipocalin (NGAL) n=18||0.4(-0.08,0.7)||0.09||0.09(-0.4,0.5)||0.7|
|Insulin-like binding protein-7(IGFBP-7)n=9||-0.7(-0.9,-0.2)||0.02||-0.3(-0.8,0.5)||0.5|
|Tissue injury marker protein-2 (TIMP-2)n=8||-0.1(-0.8,0.6)||0.7||0.8 (0.3,0.9)||0.007|
|α-1 microglobulin (α-1m)n=9||0.7(-0.03,0.9)||0.06||0.6(-0.2,0.9)||0.1|
|Kidney Injury Marker-1 (KIM-1)n=21||0.003(-0.4,0.4)||0.9||0.3(-0.1,0.7)||0.1|
and with the post-LT renal function in Table 3Conclusions: elevated α-1m and low IGFBP-7 may reflect renal fibrosis LT candidates.No consistent pattern of UBio with post-LT renal function was observed.
CITATION INFORMATION: Wadei H, Belcher J, Parikh C, Gonwa T, Mai M, Lieske J. Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Wadei H, Belcher J, Parikh C, Gonwa T, Mai M, Lieske J. Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/urine-biomarkers-ubio-correlate-poorly-with-pre-liver-transplant-lt-kidney-biopsy-findings-and-post-lt-kidney-function/. Accessed July 24, 2021.
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