Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function.
1Transplant, Mayo Clinic, Jacksonville, FL
2Medicine, Section of Nephrology, Yale University, New Haven, CT
3Medicine, Division of Nephrology, Mayo Clinic, Rochester, MN
Meeting: 2017 American Transplant Congress
Abstract number: D40
Keywords: Kidney/liver transplantation, Liver transplantation, Renal dysfunction
Session Information
Session Name: Poster Session D: Diagnostics/Biomarkers Session II
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
UBio might be valuable in determining the etiology of renal dysfunction in LT candidates.Aim: Correlate UBio with pre-LT kidney biopsy and post-LT kidney function.Methods:78 LT candidates with renal dysfunction (iothalamate GFR<40ml/min or proteinuria>500mg/d) had pre-LT UBio. 28 patients had either pre-LT (n=20) or intra-operative (n=8) kidney biopsy. 58 patients received LT. Serum Cr and 24-hr urine Cr clearance were measured post-LT. UBio were correlated with the % interstitial fibrosis (IF) and % glomerulosclerosis (GS) on kidney biopsy and post-LT renal function.Results: Patients' demographics and biopsy findings are in Table 1
| Variable | N=78 |
| Median age | 61 |
| %Caucasian | 92 |
| %Male | 53 |
| %HCV | 31 |
| %Diabetes Mellitus | 41 |
| %Hypertension | 61 |
| Median serum Cr | 1.8 (0.6,3.3) |
| Median iGFR | 29 (9,127) |
| Kidney Biopsy findings | N=28 |
| Median %IF | 5 (0,40) |
| Median %GS | 22 (0,77) |
Correlations of UBio with biopsy findings are in Table 2
| Urinary biomarker | Correlation with %IF | P | Correlation with %GS | P |
| Neutrophil gelatinase-associated lipocalin (NGAL) n=18 | 0.4(-0.08,0.7) | 0.09 | 0.09(-0.4,0.5) | 0.7 |
| Insulin-like binding protein-7(IGFBP-7)n=9 | -0.7(-0.9,-0.2) | 0.02 | -0.3(-0.8,0.5) | 0.5 |
| Tissue injury marker protein-2 (TIMP-2)n=8 | -0.1(-0.8,0.6) | 0.7 | 0.8 (0.3,0.9) | 0.007 |
| α-1 microglobulin (α-1m)n=9 | 0.7(-0.03,0.9) | 0.06 | 0.6(-0.2,0.9) | 0.1 |
| Interleukin-18 (IL-18)n=23 | 0.2(-0.5,0.3) | 0.4 | -0.5(-0.7,-0.05) | 0.03 |
| Kidney Injury Marker-1 (KIM-1)n=21 | 0.003(-0.4,0.4) | 0.9 | 0.3(-0.1,0.7) | 0.1 |
and with the post-LT renal function in Table 3
Conclusions: elevated α-1m and low IGFBP-7 may reflect renal fibrosis LT candidates.No consistent pattern of UBio with post-LT renal function was observed.
CITATION INFORMATION: Wadei H, Belcher J, Parikh C, Gonwa T, Mai M, Lieske J. Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Wadei H, Belcher J, Parikh C, Gonwa T, Mai M, Lieske J. Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/urine-biomarkers-ubio-correlate-poorly-with-pre-liver-transplant-lt-kidney-biopsy-findings-and-post-lt-kidney-function/. Accessed May 11, 2025.« Back to 2017 American Transplant Congress