*Purpose: Recently the mortality of living kidney donors was demonstrated to be significantly worse than that of healthy general population. However, the impact of preoperative comorbidities of living kidney donors were not assessed properly. We investigated the impact of preoperative glucose intolerance and hypertension on the living kidney donors.

*Methods: 802 out of 807 living kidney donors who underwent donor nephrectomy between January 2008 and December 2016 and were followed up more than 5 months after operation were enrolled in this study. Preoperative comorbidities included hypertension, dyslipidemia, glucose intolerance, and obesity. Postoperative estimated glomerular filtration rate (eGFR) and mortality of living kidney donors with both glucose intolerance and hypertension were compared with those of healthy living kidney donors without preoperative comorbidities using linear mixed model analysis and log-rank tests.

*Results: Delta eGFRs of living kidney donors with both glucose intolerance and hypertension in every time point demonstrated to be similar to those in healthy living kidney donors without pre-operative comorbidities (Figure 1).

Log-rank tests stratified by age (≥60 years or <60 years) and sex showed no significant difference in mortality between 2 groups (Figure 2).

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*Conclusions: The postoperative eGFR and mortality of living kidney donors with both glucose intolerance and hypertension were similar to those of healthy living kidney donors without preoperative comorbidities when followed up properly after operation.

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