The Effect of the Beneficial Activity of α-Lipoic Acid Treatment Depend on the Quality of the Graft Kidneys

F. Osella¹, N. Ambrosi², G. Werber¹, F. Caro², S. Beltramino¹, I. Cabrera¹, G. Hilchenbach¹, L. Diaz Alvarez¹, C. Incardona³, E. Chuluyan², D. Casadei¹

¹Instituto de Trasplante y Alta Complejidad, Buenos Aires, Argentina, ²CEFYBO, UBA, Buenos Aires, Argentina, ³GADOR S.A., Buenos Aires, Argentina

Meeting: 2019 American Transplant Congress

Abstract number: D252

Keywords: Donors, marginal, Kidney, Preservation solutions, Reactive oxygen species

Session Information

Session Name: Poster Session D: Non-Organ Specific:Organ Preservation/Ischemia Reperfusion Injury

Session Type: Poster Session

Date: Tuesday, June 4, 2019

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: In a previous preliminary study, with a small number of patients, we observed that the treatment of the donor and the recipient with the antioxidant α-lipoc acid (ALA) could not prevent the delay of the graft function, but it improved the patient’s conditions by reducing the dialysis requirements. The objective of the present work was to increase the number of patients recruited and compare the effect of ALA administration in patients transplanted with good or bad quality kidneys grafts assessed by KDPI index.

*Methods: This study included 63 patients. Among them, 32 were treated with placebo and 31 were treated with 600 mg of ALA immediately before the surgical procedure and the graft was perfused with 600 mg of ALA 1 hour before surgery. Among patients treated with ALA, 10 or 21 patients received kidneys with KDPI above or below the 75 index. In the group of patients treated with placebo, 16 patients received kidneys with a KDPI < 75, while the others 16 received grafts with KDPI > 75 index. Blood samples were obtained before surgery and every day and up to 7 days after kidney transplantation. The primary outcome was to evaluate the presence of DGF, while the levels of creatinine in plasma, blood urea nitrogen (BUN) and MDRD were used as parameters of early secondary clinical outcomes.

*Results: Among patients who received kidneys with KDPI less than 75, the presence of DGF (defined as the use of dialysis in the first postoperative week) was not different between patients treated with ALA or placebo. However, among patients who received kidneys with KDPI greater than 75, the presence of DGF was greater in patients treated with placebo compared to patients treated with ALA. Plasma creatinine and BUN were lower, whereas MDRD was higher for the group treated with ALA than for the control group. However, these differences were observed at different time points according to the type of kidney that the patients received. For those patients who received kidneys with KDPI <75, the beneficial effect was observed on the first day, while it could only be observed on the 4th day post-transplant, if the patients received a kidney with a KDPI score> 75.

*Conclusions: In general, this study confirms that treatment with ALA improves the function of the graft in the short term, but the kinetics of the beneficial effect is different depending on the quality of the graft.

To cite this abstract in AMA style:

Osella F, Ambrosi N, Werber G, Caro F, Beltramino S, Cabrera I, Hilchenbach G, Alvarez LDiaz, Incardona C, Chuluyan E, Casadei D. The Effect of the Beneficial Activity of α-Lipoic Acid Treatment Depend on the Quality of the Graft Kidneys [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/the-effect-of-the-beneficial-activity-of-%ce%b1-lipoic-acid-treatment-depend-on-the-quality-of-the-graft-kidneys/. Accessed November 22, 2024.

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