Date: Monday, June 3, 2019
Session Name: Poster Session C: Kidney: Cardiovascular and Metabolic
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Newly developed hyperglycemia and worsening of previously well controlled glucose control are common after transplantation because of stressful condition and immunosuppressive agents including of high or medium dose glucocorticoid. However, there are few evidences to show the degree of glucose fluctuation exactly after transplantation according to the transplanted organ during postoperative period in non-diabetic or preexisting diabetic patients. The aim of this study was to investigate the glucose profiles and compare this pattern between liver transplantation (LT) and kidney transplantation (KT) patients.
*Methods: We conducted a retrospective, observational study to characterize the pattern of glucose profiles of transplanted patients who underwent liver or kidney transplantation from Sep. 2017 to May. 2018 at our hospital. Patients who attached CGMS during postoperative period around 1 month after transplantation were included.
*Results: CGMS data of 26 patients (KT;19, LT;7) were analyzed in this study. LT patients included 1 pre-existing diabetes and 3 preexisting diabetes were included in KT patients. The occurrence of PTDM was 42.1% (8/19) in KT patients and 7% (1/7) in LT patients at this early point after transplantation. Glycemic control state and glycemic variability of non-diabetic patients after LT were better than KT patients in mean amplitude of glycemic excursions (MAGE; 24.62±8.78 vs 20.18±8.07, P<0.05) ADDR (465.04±65.91 vs 439.30±63.55, P<0.05) and mean absolute glucose (MAG; 24.62±8.78 vs 20.18±8.07, P<0.05) as follows. Out data shows CGMS is beneficial and sensitive to detect PTDM in the period that HbA1c or 75g OGTT is inadequate to perform after transplantation.
*Conclusions: We suggest that transplanted organ also needs to be considered as one of important factors for glucose control and occurrence of PTDM in the transplanted patients.
To cite this abstract in AMA style:Yu H, Jin H, Lee S, Yang J, Park S, Ahn S, Hwang H. The Comparison of Glycemic Profiles during Post-Operative Early Period between Liver and Kidney Transplantation Assessed by Continuous Glucose Monitoring System [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/the-comparison-of-glycemic-profiles-during-post-operative-early-period-between-liver-and-kidney-transplantation-assessed-by-continuous-glucose-monitoring-system/. Accessed October 31, 2020.
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