Tenofovir Use Is Not Associated with Reduced Bone Density or Fractures in Liver Transplant Recipients.

N. Lim, C. Engler, J. Lake.

University of Minnesota, Minneapolis, MN

Meeting: 2017 American Transplant Congress

Abstract number: B200

Keywords: Bone, Liver transplantation, Osteoporosis, Viral therapy

Session Information

Session Name: Poster Session B: Liver Retransplantation and Other Complications

Session Type: Poster Session

Date: Sunday, April 30, 2017

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Background

Tenofovir disproxil fumarate (TDF) and reduced bone density in the HIV population is well-documented. The effect of TDF use on bone density in patients who undergo liver transplantation is unknown.

Methods

A single-center, retrospective review of all patients who underwent liver transplant from 2002 to 2016. Patients receiving TDF were compared with patients who had never received TDF to evaluate for reduced bone mineral density and fractures after transplant. Reduced bone mineral density was defined as osteopenia or osteoporosis based on DEXA scan reports. Multivariate analysis was then performed for these two outcomes. Secondary analysis was performed comparing patients receiving TDF with controls with viral hepatitis. Viral hepatitis controls were defined as patients with chronic hepatitis C or B in the absence of TDF use.

Results

995 patients received liver transplants from 2002 to 2016. 343 patients were female (34.5%). 79 (7.9%) patients were transplanted with chronic hepatitis B. 11/57 (19.3%) patients on TDF developed reduced bone mineral density compared with 163/938 (17.4%) patients who had never received TDF (p=0.71). 6/57 (10.5%) patients on TDF developed fractures compared with 170/938 (18.1%) patients in the non-TDF group (p=0.14). TDF use was not associated with reduced bone mineral density (OR, 1.47; 95% CI 0.73-2.95, p=0.28) or fractures (OR, 0.815; 95% CI 0.34-1.98, p= 0.65).

There were 345 controls with viral hepatitis. 53/345 (13.18%) viral hepatitis controls developed reduced bone mineral density (p=0.45, compared to TDF) and 60/345 (14.93%) developed fractures (p=0.19). TDF use was not associated with reduced bone mineral density (OR 1.382; 95% CI 0.67-2.85, p=0.38) or fractures (OR 1.02; 95% CI 0.39-2.66, p=0.97) compared to viral hepatitis controls.

Conclusion

TDF use is not associated with reduced bone density or fractures after liver transplant. Specialized screening strategies for osteopenia or osteoporosis are not warranted for liver transplant patients on TDF.

CITATION INFORMATION: Lim N, Engler C, Lake J. Tenofovir Use Is Not Associated with Reduced Bone Density or Fractures in Liver Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Lim N, Engler C, Lake J. Tenofovir Use Is Not Associated with Reduced Bone Density or Fractures in Liver Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/tenofovir-use-is-not-associated-with-reduced-bone-density-or-fractures-in-liver-transplant-recipients/. Accessed May 17, 2025.

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