ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Successful Kidney Transplant Improves Glucose Tolerance – A Paradoxical Report From A Single Center

A. Mitsuke, H. Harada, H. Higuchi, N. Fukuzawa, H. Tanaka, T. Hirano, T. Sekii

Kidney Transplantation Surgery, Sapporo City General Hospital, Sapporo, Japan

Meeting: 2019 American Transplant Congress

Abstract number: C199

Keywords: Calcineurin, Kidney transplantation, Post-transplant diabetes, Weight

Session Information

Session Name: Poster Session C: Kidney: Cardiovascular and Metabolic

Session Type: Poster Session

Date: Monday, June 3, 2019

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: Kidney recipients tend to impair glucose tolerance because of several factors such as post-operative obesity, and chronic exposure of some diabetogenic immunosuppressants like calcineurin inhibitors (CNI), corticosteroids (CS) and mTOR inhibitors (mTORi). The rate of new onset diabetes mellitus after transplantation (NODAT) has been reported in many literatures. However, the incidence varies presumably due to the difference of definition of NODAT and the vagueness of pre-transplant glucose tolerability. We herein surveyed the real incidence of NODAT using 75g OGTT method in our institution under early corticosteroid withdrawal or extremely minimization protocols.

*Methods: One hundred sixty-three kidney recipients without clinically diagnosed overt preoperative diabetes mellitus transplanted between 2006 to 2014, whose glucose tolerance (GT) were surveyed with 75g OGTT were enrolled. They were maintained with tacrolimus/mycofenolate mofetile based immunosuppression; their CS were discontinued at POD3 or continued with a minimum dose (2-4mg as methylprednisolone) by a month. Recent 33 patients were added with mTORi everolimus from the beginning. OGTT were performed before transplantation, and 1y post-transplant. Patients whose glucose at 2h lower 140mg/dL were diagnosed normal glucose tolerance (NGT), their glucose at 2h between 140 to 199mg/dL were ranked as impaired glucose tolerance (IGT), and their glucose at 2h more than 200mg/dL were defined as diabetes (DM). We also studied the change of body mass index(BMI) and insulinogenic tolerance or secretion using calculation of HOMA-R or HOMA-β.

*Results: Out of 163 patients, pre-transplant latent DM were 18 (10.8%), IGT were 61 and rest 84 were in NGT. After 1y, 16 developed IGT, but 68 had never spoiled their GT in pre-transplant NGT patients. Among pre-operative IGT patients, 5 patients (8.2%) developed DM, 17 patients (27.9%) still remained their GT as IGT. Interestingly most of them could normalize their glucose intolerance (38, 62.3%). More interestingly, 10 patients out of 18 pre-transplant DM patients could recover their glucose tolerance at 1y (IGT 6, NGT 4) post-transplant. Then, the overall rate of real NODAT at 1y (DM at 1y / pre-operative IGT and NGT) were only 3.5% (5/143), or 14.7% (plus 16 IGT from 84 NGT) if included IGT patients. Patients who impaired their GT did not change their BMI. They exhibited the deterioration of HOMA-R not HOMA-β post-transplant.

*Conclusions: The real incidence of NODAT at 12m were extremely small different from previous literatures at least under maintenance early CS withdrawal or minimization protocol even with more diabetogenic CNI tacrolimus. More interestingly, it has been proven that GT could be recovered after successful kidney transplantation among clinically pre-operative non-diabetic population.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Mitsuke A, Harada H, Higuchi H, Fukuzawa N, Tanaka H, Hirano T, Sekii T. Successful Kidney Transplant Improves Glucose Tolerance – A Paradoxical Report From A Single Center [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/successful-kidney-transplant-improves-glucose-tolerance-a-paradoxical-report-from-a-single-center/. Accessed May 8, 2025.

« Back to 2019 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences