Serum Albumin Level Has Association with Both Graft Failure and Mortality in Kidney Transplant Recipients.
1Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea
2Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea
3Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Meeting: 2016 American Transplant Congress
Abstract number: A248
Keywords: Graft failure, Kidney transplantation, Mortality
Session Information
Session Name: Poster Session A: Long Term Outcomes in Kidney Transplantation
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: The studies concerned the association between post-transplant serum albumin concentration and post-transplant outcomes in kidney transplant recipients (KTRs) are scarce.
Methods: To evaluate the impact of serum albumin level on graft and patient survival, we performed a retrospective multi-center cohort study. A total of 2815 KTRs who underwent renal transplantation from Jan 1997 to Jan 2012 were classified into two groups according to the level of serum albumin at 1 year after transplantation (higher albumin group, ≥4.0 g/dL, n=1978 vs. lower albumin group, <4.0 g/dL, n=837). The Cox proportional hazard model was adjusted with age and gender of recipient, donor type, age of donor, diabetes mellitus, and estimated glomerular filtration rate (eGFR) at 1 year after transplantation.
Results: The mean age of the recipients was 41.7±11.3 (range, 18-73) years, and 59.1% were male. The rate of graft failure was higher in lower albumin group compared to higher albumin group (Hazard ratio [HR] 1.840, 95% confidence interval [CI] 1.367-2.477, P<0.001), even though eGFR at 1 year after transplantation was not different between the two groups (61.7±19.8 vs. 62.1±15.8 mL/min, P=0.615). Both all-cause mortality and non-cardiovascular mortality rates were higher in lower albumin group (HR 2.227, 95% CI 1.258-3.943, P=0.006, and HR 2.784, 95% CI 1.254-6.179, P=0.012, respectively). Every 1.0 g/dL higher serum albumin concentration was associated with 69.2% lower all-cause mortality (HR 0.308, 95% CI 0.196-0.483, P<0.001).
Conclusion: Serum albumin level at 1 year after transplantation is a prognostic factor for graft failure and patients' mortality in KTRs. Therefore, evaluation and management for hypoalbuminemia should be considered to improve outcomes in KTRs.
CITATION INFORMATION: Jeon H, Rhee S, Shin D, Oh J, Kim Y, Lee J. Serum Albumin Level Has Association with Both Graft Failure and Mortality in Kidney Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Jeon H, Rhee S, Shin D, Oh J, Kim Y, Lee J. Serum Albumin Level Has Association with Both Graft Failure and Mortality in Kidney Transplant Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/serum-albumin-level-has-association-with-both-graft-failure-and-mortality-in-kidney-transplant-recipients/. Accessed May 21, 2025.« Back to 2016 American Transplant Congress