Date: Tuesday, May 2, 2017
Session Name: Poster Session D: Living Donor Kidney Transplant II
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Objective: To evaluate whether volume of the remnant kidney based on pre-donation CT and donor age correlates with post-donation 2-year renal function in live kidney donors.
Materials and methods: In this retrospective single-center study, 51 live kidney donors were identified who underwent pre-donation CT and had an estimated glomerular filtration (eGFR) determination at 2 years post donation. Age, retained kidney whole and cortical volumes, and eGFR at 2 years post donation were recorded. Donor eGFR<60 ml/min/1.73m2at 2 years post-donation was used as cut-off value. Pearson correlation coefficients (PCC) evaluated the relationship of age and retained volume/BMI ratio with 2-year eGFR, and logistic regression models for those factors significantly associated with a2-year eGFR<60 were created. Optimal cut-points were identified, and models using these were created to predict eGFR<60 at the end of 2 years.
Results: Retained cortical volume/BMI ratio (CV/BMI) was the normalized volume measurement most strongly associated with the 2-year eGFR (PCC=0.66). CV/BMI and age were associated with 2-year eGFR<60 in a logistic regression model (p=0.02 and <0.01, respectively). The area under the receiver-operator curve for a model that included CV/BMI and age was 0.9. Optimal cut-points to predict eGFR≥60 at 2 years were age<45 years and CV/BMI≥4.5 mL/(kg/m2). If both risk factors were unfavorable (age>45 years and CV/BMI<4.5), the probability of a 2-year eGFR<60 estimated by the model was 92%. If both did not meet the age and BMI thresholds (age<45 years and CV/BMI≥4.5), the probability was 3%. If only one factor was favorable (age<45 years or CV/BMI≥4.5), the probability was 36 or 39%, respectively. (Table 1)
Conclusion: Pre-donation CT CV/BMI ratio of the remnant kidney and age are important factors inpredicting eGFR<60 in donors 2 years post donation and may thus provide important decision support during the live donor selection process.
Table 1 Probability of 2-year GFR < 60 ml/min/1.73m2based on age and normalized cortical volume
|CV/BMI ≥ 4.5 mL/(kg/m2)||CV/BMI < 4.5 mL/(kg/m2)|
|Age < 45||3%||36%|
CITATION INFORMATION: Chen L.-X, Fananapazir G, Benzl R, Corwin M, Stewart S, Troppmann C. Semi-Automated Pre-Donation Computed Topography (CT) Cortical Renal Volume to Predict Kidney Function in Live Kidney Donors 2 Years Following Donation. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Chen L-X, Fananapazir G, Benzl R, Corwin M, Stewart S, Troppmann C. Semi-Automated Pre-Donation Computed Topography (CT) Cortical Renal Volume to Predict Kidney Function in Live Kidney Donors 2 Years Following Donation. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/semi-automated-pre-donation-computed-topography-ct-cortical-renal-volume-to-predict-kidney-function-in-live-kidney-donors-2-years-following-donation/. Accessed September 22, 2019.
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