Sars-cov-2 Antibodies Transitions After Vaccination In Solid Organ Transplant Recipients: Multicenter Study In Japan
1Tokyo Women's Medical University, Tokyo, Japan, 2Kyoto Prefectural University of Medicine, Kyoto, Japan, 3University of Miami, Pinecrest, FL, 4Kyoto University, Kyoto, Japan, 5Dept. of Urology, Osaka Univ. Graduate School of Medicine, Suita, Japan, 6Renal Transplantation, Takatsuki General Hospital, Takatsuki, Japan, 7Kansai Medical Hospital, Toyonaka, Japan, 8Tranplantation Surgery, National Hospital Organization Mito Medical Center, Mito, Japan, 9Public Health, Osaka City University Graduate School of Medicine and Research Center for Infectious, Osaka City University Graduate School of Medicine, Osaka, Japan, 10Clinical Epidemiology Research Center, Miyama, Japan
Meeting: 2022 American Transplant Congress
Abstract number: 9063
Keywords: COVID-19, Multicenter studies, Vaccination
Topic: Basic & Clinical Science » Basic & Clinical Science » 73 - COVID-19
Session Information
Session Time: 7:00pm-8:00pm
Presentation Time: 7:00pm-8:00pm
Location: Hynes Halls C & D
*Purpose: For purpose of SARS-CoV-2 infection control, vaccination was started in worldwide, however, low reactivity of antibody production after vaccination is a concern for solid organ transplant (SOT) recipients. In general, antibody titers would be peaked within one month after vaccination for the healthy population, there are few report about SOT recipients vaccination. We explored antibody transitions in SOT recipients after vaccination.
*Methods: A total of 641 solid organ transplant recipients were enrolled (481 kidney, 51 liver, 54 heart, 20 lung, and 35 simultaneous pancreas-kidney). All participants were administered the two-dose regimen mRNA vaccine (BNT162b2, Pfizer or mRNA-1273, Moderna), as indicated. SARS-CoV-2 antibodies were measured total 5 times throughout vaccination (Elecsys®, Roche).
*Results: The antibody titer and positive rate were both elevated until three months and declined at six months after vaccination (positive rate; 10.4%, 41.2%, 68.6%, 56.9%, in each) (Fig.1). Lung and kidney-pancreas transplant recipients showed poor antibody titer elevation compared with other organ transplantation (Fig. 2). Antibody titers be significant low by more than 60 years old compared with other ages (Fig.3).
*Conclusions: The antibody titer and positive rate transition of SOT recipients were quite different compared with the health population. The acquisition of antibody was different depends on type of SOT.
To cite this abstract in AMA style:
Unagami K, Yoshikawa M, Natori Y, Omoto K, Ishida H, Date H, Imamura R, Ito T, Miyaji K, Takahara S, Yuzawa K, Satoko O, Hirota Y, Egawa H. Sars-cov-2 Antibodies Transitions After Vaccination In Solid Organ Transplant Recipients: Multicenter Study In Japan [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/sars-cov-2-antibodies-transitions-after-vaccination-in-solid-organ-transplant-recipients-multicenter-study-in-japan/. Accessed May 18, 2025.« Back to 2022 American Transplant Congress