Renal Transplantation in Aged Over 60 Years Demonstrates Compatible Clinical Outcomes to Younger Recipients

H. Cho,¹ H. Kim,¹ C. Baeck,¹ H. Yu,¹ D.-J. Han,² M. Jo,³ S.-K. Park.¹

¹Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
²Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
³Department of Preventive Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

Meeting: 2015 American Transplant Congress

Abstract number: D54

Keywords: Age factors, Graft survival, Kidney transplantation, Outcome

Session Information

Session Name: Poster Session D: Disparities in Healthcare Outcomes

Session Type: Poster Session

Date: Tuesday, May 5, 2015

Session Time: 5:30pm-6:30pm

Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Introduction: The aim of this study was comparing clinical outcomes of kidney transplantation between aged over 60 years and younger recipients

Methods: From 1993 to 2013, kidney transplantations performed in Asan medical center were retrospectively reviewed. Death censored graft survival and standardized mortality ratios (SMR) were analyzed. Risk factors of graft failures at 10 years after transplantation were assessed by binary logistic regression.

Results: In living donor kidney transplantation, 10 year death censored graft survival of the young age group was 87.5% and that of the geriatric group was 87.2% (log rank p=0.215). In deceased donor kidney transplantation, 10 year death censored graft survival of the young age group was 79% and that of the geriatric group was 90.9% (log rank p=0.119). SMRs of geriatric group were not inferior to younger recipients.

Age group specific standardized mortality ratios of kidney transplantation recipients.
	Age group	N	Observed number of death	Expected number of death	SMR∗	95%CI†
		3205	252	103.50	2.43	2.14-2.75
Totals	20-59	3013	219	87.44	2.50	2.18-2.86
	≥60	192	33	16.06	2.06	1.41-2.89
Living donor	20-59	2382	148	66.99	2.21	1.87-2.60
	≥60	153	22	12.41	1.77	1.11-2.68
Deceased donor	20-59	631	71	20.45	3.47	2.71-4.38
	≥60	39	11	3.65	3.01	1.50-5.39

∗SMR:Standardized mortality ratios, †CI: Confidence intervalIt was revealed thant aged over 60 years recipients was not a risk factor of graft failure at 10 years after transplantation in deceased donor kidney transplantation

Risk factors of graft failure at 10 years after transplantation in deceased donor kidney transplantation
		Univariate analysis			Multivariate analysis
	P-value	Hazard ratio	95% CI†	P-value	Hazard ratio	95% CI†
+60 years	0.646	1.23	0.51-2.98
Donor age	0.041	1.02	1.00-1.03	0.047	1.02	1.00-1.03
Female	0.185	0.75	0.49-1.15
Diabetes mellitus	0.004	2.68	1.38-5.21	0.001	2.87	1.53-5.37
Hypertension	0.810	0.89	0.34-2.31
Glomerula disease	0.446	0.77	0.40-1.50
Time of transplantation (2004-2013)	< 0.001	0.22	0.13-038	<0.001	0.21	0.13-0.34
HLA DR mismatch	0.890	0.95	0.43-2.08
Dialysis before transplantation	0.380	2.09	0.40-10.83
Re-transplantation	0.502	1.30	0.61-2.76

Conclusion: Kidney transplantation in geriatric population can be encouraged.

To cite this abstract in AMA style:

Cho H, Kim H, Baeck C, Yu H, Han D-J, Jo M, Park S-K. Renal Transplantation in Aged Over 60 Years Demonstrates Compatible Clinical Outcomes to Younger Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/renal-transplantation-in-aged-over-60-years-demonstrates-compatible-clinical-outcomes-to-younger-recipients/. Accessed May 19, 2025.

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