Renal Allograft Outcome from Hypertensive Donor: Comparison between Living and Deceased Donor
1Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, 2Pusan National University Hospital, Pusan, Korea, Republic of, 3Ewha Womans University Medical Center, Seoul, Korea, Republic of, 4Kosin University College of Medicine, Pusan, Korea, Republic of, 5Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, 6Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of, 7Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seoul, Korea, Republic of
Meeting: 2020 American Transplant Congress
Abstract number: A-081
Keywords: Graft failure, Graft function
Session Information
Session Name: Poster Session A: Kidney Living Donor: Selection
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: Donor shortage is a serious problem in renal transplantation, and hypertensive living donor is potential candidates to expand donor pool. However, it is not unclear that renal allograft outcome from hypertensive living donor is similar compared to normotensive living donor or deceased donor.
*Methods: A total of 4311 renal transplant recipients from the Korea Organ Transplantation Registry (KOTRY) database were enrolled from Jul 2014 to Dec 2018. We tried to investigate the renal allograft survival rate and estimated glomerular filtration rate (eGFR) of renal transplant recipients from hypertensive living donor (n = 280), compared to those from living normotensive donor (n = 2723) and deceased donor with or without hypertension (n = 262 and n = 1046, respectively).
*Results: Renal transplant recipients from hypertensive living donor exhibited significantly worse death-censored graft survival rate than those from normotensive living donor (p = 0.028). The allograft survival rate was not different between normotensive and hypertensive deceased donors (p = 0.649). In multivariate Cox-regression model, the renal allograft from normotensive donor was significantly associated with better survival rate compared to recipients from normotensive living donor (95% CI 0.18-0.91; p = 0.028). The recipients of hypertensive living donor did not show better graft survival rate compared to those of deceased donor with and without hypertension. The renal allograft from hypertensive donor was associated with lower eGFR than those from normotensive living and deceased donor without hypertension during entire follow up. The presence of donor proteinuria and more than 50 years-old recipients further increased the risk of renal allograft loss in hypertensive living donor transplantation. However, these relationships were not observed in hypertensive deceased donor transplantaion.
*Conclusions: Renal allograft from hypertensive living donor had increased the risk of renal allograft loss and associated with lower eGFR. We need the strategy to screen the hypertensive donor with high risk for renal allograft loss in hypertensive living donor transplantation.
To cite this abstract in AMA style:
Hwang H, Kong J, Kim J, Kim Y, Moon J, Jeong K, Song S, Song S, Shin H, Yang J, Ahn C, Lee Y, Lee S. Renal Allograft Outcome from Hypertensive Donor: Comparison between Living and Deceased Donor [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/renal-allograft-outcome-from-hypertensive-donor-comparison-between-living-and-deceased-donor/. Accessed May 16, 2025.« Back to 2020 American Transplant Congress