Redo Kidney Transplant in FSGS

J. Verbesey, A. Javaid, S. Yi, G. Vranic, A. Gilbert, P. Abrams, S. Ghasemian, J. Moore, B. Thomas, M. Cooper, B. Javaid.

Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, Washington, DC.

Meeting: 2018 American Transplant Congress

Abstract number: 108

Keywords: Glomerulonephritis, Graft failure, Kidney transplantation, Recurrence

Session Information

Session Name: Concurrent Session: Kidney Complications: Disease Recurrence

Session Type: Concurrent Session

Date: Sunday, June 3, 2018

Session Time: 4:30pm-6:00pm

Presentation Time: 5:30pm-5:42pm

Location: Room Hall 4B

Objective: Analyze risk of graft failure due to recurrent FSGS in patients with prior failed kidney transplants under consideration for a subsequent transplant.

Results: We identified 14,384 patients with FSGS who underwent a kidney transplant from 10/14/1987 to 5/22/2009 in UNOS dataset. Of those, 13,214 were recipients of first kidney transplant while the remaining 1,105 patients had had at least one or more prior kidney transplants. Among first transplant recipients 428 (3.2%) patients experienced graft failure due to recurrent FSGS compared to 65 (5.6%) patients who had a prior kidney transplant and lost the subsequent transplant to recurrent disease (RR 1.7; 95% CI, 1.3-2.2; p< 0.001). In a subset of 68 patients with FSGS who had had 2 or more prior transplants, the risk of graft failure due to disease recurrence was more pronounced (RR 3.6; 95% CI, 1.9-6.9; p<0.001). However, redo transplant recipients in the entire cohort did not exhibit a significantly increased risk for graft loss attributed to disease recurrence compared to all other causes of graft failure (RR 1.2; 95% CI, 0.9-1.5; p=0.22).

Conclusions:In patients with kidney failure due to FSGS, while risk of graft failure due to recurrent disease was higher in individuals with prior kidney transplants compared to those undergoing first kidney transplants, the overall risk of graft loss due to recurrence of FSGS was not significantly different when compared to other cause of graft failure. These data indicate that while FSGS patients with prior failed transplants should be advised of the higher risk of graft failure due to recurrence, given the magnitude of this risk and comparable graft survival probability, patients and transplant programs should not be unduly deterred from consideration for a redo transplant.

CITATION INFORMATION: Verbesey J., Javaid A., Yi S., Vranic G., Gilbert A., Abrams P., Ghasemian S., Moore J., Thomas B., Cooper M., Javaid B. Redo Kidney Transplant in FSGS Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Verbesey J, Javaid A, Yi S, Vranic G, Gilbert A, Abrams P, Ghasemian S, Moore J, Thomas B, Cooper M, Javaid B. Redo Kidney Transplant in FSGS [abstract]. https://atcmeetingabstracts.com/abstract/redo-kidney-transplant-in-fsgs/. Accessed May 16, 2025.

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