Introduction: Primary FSGS can recur in the renal allograft and is associated with poor outcomes. The aim of this study was to assess the prevalence of recurrent FSGS and to identify risk factors of recurrence.

Methods: We studied retrospectively our renal transplant recipients (2005-2016) with primary FSGS, who were diagnosed post-transplantation with biopsy-proven recurrent FSGS. Using electronic health records, we collected data regarding demographics, kidney survival and FSGS histological type. Patients with secondary FSGS, missing data and those lost to follow up were excluded.

Results: 121 patients with primary FSGS were included in the study. The prevalence of recurrent FSGS was 22.3%. Patients with recurrent FSGS were younger at transplantation, compared to the patients who did not recur (36 vs 44 years, p=0.05). We found no significant differences for the other variables studied. Patients with recurrent FSGS were mostly Caucasians (77.8%) and underwent living donor transplantation (62.9%). Patients who recurred, had history of rapid progression to End Stage Renal Disease (median time of 3.1 years, IQI 0.92- 5.70) and rapid loss of previous grafts (median survival of 1.5 years, IQI 0.92-2.18). The median time from transplantation to recurrence was 3.96 months (IQI 0.90-18.5). There was no correlation between the histological type of FSGS in the native kidney biopsy and in the allograft biopsy.

Discussion: The prevalence of recurrent FSGS post-transplantation in our population was lower than the reported in the literature. Renal transplant patients with recurrent FSGS were more likely to be Caucasians, younger at transplantation, with history of rapid progression to ESRD and rapid loss of previous allografts.

CITATION INFORMATION: Aguiar R., Gasparini A., Chowdhury P., Game D., Moutzouris D. Recurrent FSGS Post-Transplantation: Prevalence and Risk Factors Am J Transplant. 2017;17 (suppl 3).

« Back to 2018 American Transplant Congress