Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Arterial calcification is common in patients with end stage renal disease and is often accompanied by wall hypertrophy. The aims of this study are quantitative measuring of iliac artery calcification and wall thickness via computed tomography (CT) images and investigation of their clinical significance for kidney transplant (KT) recipients.
*Methods: From October, 2010 to December, 2012, the recipient data of Seoul national university hospital renal transplantation database was analyzed retrospectively. All recipients were followed up for 5 years. The recipients who were younger than 40 and received ABO incompatible KT were excluded to avoid congenital vascular problem and effect of more potent immunosuppression. Area of recipient arterial wall and lumen were measured geometrically, and arterial calcification was calculated by Hounsfield units (HU) per unit area using pre-KT CT images.
*Results: Through the criteria, 152 recipients were analyzed. Graft artery was anastomosed to common iliac artery (CIA) in 74 recipients, to external iliac artery (EIA) in 50 recipients, and to internal iliac artery (IIA) in 28 recipients. Mean arterial wall calcification was 331.7 ± 227.8 HU in CIA, 174.7 ± 105.1 HU in EIA, 185.4 ± 60.6 HU in IIA of anastomosis site. Wall calcification was statistically associated with GFR at postoperative 1 week (p=0.022) and at first year (p=0.040). However, there was no difference between two groups that was divided by median value (HU) of calcification during the study period. In multiple regression analysis, Calcification of anastomosis site was associated with lower GFR at 1 week (p=0.024) and first year (p=0.039).
*Conclusions: Geometric measurement using CT image can be useful option to estimate arterial status quantitatively. Arterial calcification of anastomosis site is negatively associated with eGFR in early period after KT. Therefore, preoperative quantitative measurement of arterial calcification via CT images can be useful to anticipate early prognosis of KT. Prospective study with serial follow-up of arterial duplex sonography to iliac arteries and graft renal artery will support and confirm this result.
To cite this abstract in AMA style:Choi C, Han A, Ahn S, Ahn M, Min S, Ha J. Quantitative Measuring of Iliac Artery Calcification in Renal Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/quantitative-measuring-of-iliac-artery-calcification-in-renal-transplantation/. Accessed February 19, 2020.
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