Propensity-Score Matched Comparison of Lung Transplant Recipients of Age <70 and ≥70 Years.
1Cardiovascular Surgery, Temple University, Philadelphia, PA
2Clinical Sciences, Temple University, Philadelphia, PA
3Thoracic and Pulmonary Medicine, Temple University, Philadelphia, PA
Meeting: 2017 American Transplant Congress
Abstract number: B251
Keywords: Age factors, Lung transplantation, Survival
Session Information
Session Name: Poster Session B: Lung Transplantation Poster Session
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Purpose: To validate the utilization of lung transplantation (LTx) recently in older recipients, we compared the survival outcome of the LTx recipients of age <70 versus ≥70 years and compared the demographics and other clinical parameters for any statistical significance after propensity-score matching in both groups.
Methods: Out of 251 LTx recipients in our center (2012-2016), we found similar 58 patients in each group (<70 vs ≥ 70 years) after propensity-score matching. Using K-M curve, survival days and numbers of death along with demographics were compared for significance using STATA Inc.
Results: As expected, there were significant differences in age groups (62±8 vs 73±2; p<0.0001) with similar LAS (50±19 vs. 53±20; p=0.28). There were no differences in recipient ethnicity (p=0.57), BMI (28±5 vs. 27±5 kg/m2; p=0.98), recipient height (p=0.32); recipient gender (46-male vs. 45-male; p=0.85); donor age (p=0.97), donor height (p=0.21), and donor sex (41-male vs. 41-male; p=1.00). Etiology for LTx recipients had no differences with 47-IPF, 8-COPD, 3-others in <70 age group vs. 48-IPF, 7-COPD, 3-others in ≥70 age; p=0.96. There were no differences in CPB usage (p=0.41) and lung transplant type (23 single vs 35 double LTx in each group; p=1.00). Antero-axillary, Clamshell, and Median Sternotomy incisions were similar in both groups (p=0.15). Median LOS were similar in both groups (18 vs. 17 days; p=0.80). Figure (K-M Curve) shows no survival difference (474 vs. 431; p=0.72) in both groups. 
Conclusion: In a single center, propensity-score matching study showed successful lung transplants in older patients with comparable outcome and no inferiority to younger recipients. Careful planning of the lung transplant surgical techniques may help the older patients to obtain the highest benefit out of such complex procedure.
CITATION INFORMATION: Kashem A, Keshavamurthy S, Gomez-Abraham J, Yoshizumi T, Zhao H, Cordova F, Criner G, Toyoda Y. Propensity-Score Matched Comparison of Lung Transplant Recipients of Age <70 and ≥70 Years. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Kashem A, Keshavamurthy S, Gomez-Abraham J, Yoshizumi T, Zhao H, Cordova F, Criner G, Toyoda Y. Propensity-Score Matched Comparison of Lung Transplant Recipients of Age <70 and ≥70 Years. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/propensity-score-matched-comparison-of-lung-transplant-recipients-of-age-70-and-70-years/. Accessed November 21, 2024.« Back to 2017 American Transplant Congress