Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs

C. Falk,^1,7 F. Schlott,^2,7 K. Katsrintaki,^1,7 D. Steubl,³ W. Puppe,⁴ C. Blume,⁵ H. Haller,⁶ L. Renders,³ U. Heemann,³ D. Busch,² M. Neuenhahn.^2,7

¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany
²Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
³Department of Nephrology, Technical University Munich, Munich, Germany
⁴Institute of Virology, Hannover Medical School, Hannover, Germany
⁵Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany
⁶Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
⁷DZIF TTU-IICH, DZIF, Hannover / Munich, Germany.

Meeting: 2018 American Transplant Congress

Abstract number: A18

Keywords: Cytomeglovirus, Kidney transplantation

Session Information

Session Name: Poster Session A: Biomarkers, Immune Monitoring and Outcomes

Session Type: Poster Session

Date: Saturday, June 2, 2018

Session Time: 5:30pm-7:30pm

Presentation Time: 5:30pm-7:30pm

Location: Hall 4EF

Introduction: Human Cytomegalovirus (CMV) infection is still a major risk factor for immunocompromised patients, e.g. kidney recipients. Based on the CMV serostatus of donor (D) and recipient (R) several risk groups are defined: low (D-/R-), intermediate (D+/R+ or D-/R+), high risk (D+/R-) patients. In a preliminary study (Schlott et al 2016), cold ischemia time (CIT) was shown to be associated with primary CMV infection in D+R- high risk patients.

Patients: At MHH, from a cohort of 131 kidney recipients, CMV D+/R- (n=21) high risk patients were analyzed for CMV infection/seroconversion, correlated with CIT and immunophenotyping was performed.

Results: CIT differed significantly between 10 living donors (median=145min) and 11 deceased donors (median=565min; p<0.0001). Patients without CMV infection (n=15) had significantly shorter CIT (median=177 min) compared to 6 patients with primary CMV infection and prolonged CIT (median=755min; p=0.001). Furthermore, none of the 10 recipients of living donor kidneys developed CMV infection/seroconversion while 6 of 11 recipients of deceased donor kidneys displayed CMV positivity after at least 6 months post Tx (p= 0.001).

Conclusion: Taken together, with two cohorts of kidney recipients at TUM and MHH, we could confirm that prolonged CIT is associated with an increased risk for primary CMV infection in D+/R- high risk recipients. This observation may have clinical relevance for the antiviral treatment of this high risk group, especially in deceased donor kidney transplantations with naturally prolonged CIT.

CITATION INFORMATION: Falk C., Schlott F., Katsrintaki K., Steubl D., Puppe W., Blume C., Haller H., Renders L., Heemann U., Busch D., Neuenhahn M. Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Falk C, Schlott F, Katsrintaki K, Steubl D, Puppe W, Blume C, Haller H, Renders L, Heemann U, Busch D, Neuenhahn M. Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs [abstract]. https://atcmeetingabstracts.com/abstract/primary-cytomegalovirus-infection-in-seronegative-kidney-transplant-patients-is-associated-with-prolonged-cold-ischemic-time-of-seropositive-donor-organs/. Accessed May 16, 2025.

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