ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Physiological Age by Artificial Intelligence-Enhanced Electrograms as a Novel Biomarker of Mortality in Kidney Transplant Candidates

E. Lorenz, I. Zaniletti, B. Johnson, T. Petterson, W. Kremers, C. Schinstock, H. Amer, A. Cheville, N. LeBrasseur, A. Baez-Suarez, Z. Attia, F. Lopez-Jimenez, P. Friedman, C. Kennedy, A. Rule

Mayo Clinic, Rochester, MN

Meeting: 2022 American Transplant Congress

Abstract number: 25

Keywords: Adverse effects, Age factors, Outcome, Waiting lists

Topic: Clinical Science » Kidney » 35 - Kidney: Cardiovascular and Metabolic Complications

Session Information

Session Name: Kidney: Cardiovascular and Metabolic Complications I

Session Type: Rapid Fire Oral Abstract

Date: Sunday, June 5, 2022

Session Time: 3:30pm-5:00pm

 Presentation Time: 3:50pm-4:00pm

Location: Hynes Veterans Auditorium

*Purpose: Assessing mortality risk prior to kidney transplantation is challenging. Age-Gap, which is the difference between physiological age determined by artificial intelligence-enhanced electrocardiograms (ECG) and chronological age, has been associated with risk of mortality in non-transplant populations. The aim of this study was to determine whether Age-Gap is also associated with mortality in kidney transplant candidates.

*Methods: We applied a previously developed convolutional neural network to the ECGs of patients who underwent kidney transplant evaluation at our center between 2014 and 2019 to determine physiological age. All patients underwent ECG assessment during kidney transplant evaluation at our center. We used a Cox proportional hazard model to examine whether Age-Gap was associated with mortality among waitlisted candidates. We adjusted for chronological age and Charlson comorbidity index. Patients were censored at the time of kidney transplantation.

*Results: Of the 2,213 patients evaluated, 59.1% were male, 33.9% had diabetes, and 81.3% were Caucasian. Over a mean follow-up time of 1.7 ± 1.4 years, 11.3% of patients died. Mean ECG-predicted physiological age was 58.6 ± 12.5 years, while mean chronological age at ECG was 52.7 ± 14.4 years (R2 = 0.6, p < 0.001). The mean Age-Gap was 5.9 ± 9.3 years. Patients with an Age-Gap > 1 standard deviation (SD) older than their chronological age were significantly more likely to experience waitlist mortality than patients with an Age-Gap ≤ 1 SD (HR = 1.8; 95% CI 1.1-2.8; p = 0.013) after adjusting for chronological age and Charlson comorbidity index.

*Conclusions: The ECG-predicted physiological age is a biomarker of waitlist mortality in kidney transplant candidates after adjusting for chronological age and prognostic comorbidities. Determining ECG-predicted physiological age through artificial intelligence may help guide risk-benefit assessment when evaluating and approving candidates for kidney transplantation.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Lorenz E, Zaniletti I, Johnson B, Petterson T, Kremers W, Schinstock C, Amer H, Cheville A, LeBrasseur N, Baez-Suarez A, Attia Z, Lopez-Jimenez F, Friedman P, Kennedy C, Rule A. Physiological Age by Artificial Intelligence-Enhanced Electrograms as a Novel Biomarker of Mortality in Kidney Transplant Candidates [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/physiological-age-by-artificial-intelligence-enhanced-electrograms-as-a-novel-biomarker-of-mortality-in-kidney-transplant-candidates/. Accessed May 30, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences