Perfusate Il-6 Levels During Liver Nmp Are Predictive For Hemodynamic Response And Catecholamine Demand After Reperfusion In The Recipient

A. Weissenbacher¹, S. Mathis², B. Cardini¹, C. Bogensperger¹, G. Putzer², L. Gasteiger², T. Resch¹, R. Oberhuber¹, D. Öfner¹, T. Hell³, J. Martini², S. Schneeberger¹

¹Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria, ²Department of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria, ³Department of Mathematics, Faculty of Mathematics, Computer Science and Physics, University of Innsbruck, Innsbruck, Austria

Meeting: 2022 American Transplant Congress

Abstract number: 9040

Keywords: Liver, Preservation

Topic: Clinical Science » Organ Inclusive » 69 - Non-Organ Specific:Organ Preservation/Ischemia Reperfusion Injury

Session Information

Session Name: Non-Organ Specific: Organ Preservation/Ischemia Reperfusion Injury

Session Type: Poster Abstract

Date: Saturday, June 4, 2022

Session Time: 5:30pm-7:00pm

Presentation Time: 5:30pm-7:00pm

Location: Hynes Halls C & D

*Purpose: Normothermic liver preservation (NMP) has become a clinical routine at several transplant centres. Reperfusion-syndrome occurs less often in recipients of NMP-livers compared to cold stored livers. We hypothesized that perfusate interleukin (IL)-6 during

*Methods: Consecutive NMP-liver transplants at a single-centre were prospectively analysed. Perfusate samples were collected at 1 and 6 hours of NMP and at the end of perfusion and analysed for IL-6 levels. Median arterial pressure (MAP) and catecholamine need during surgery were recorded. The anhepatic phase was defined as baseline for MAP and catecholamine requirements.

*Results: Over a period of 36 months, IL-6 perfusate measurements were assessed in 77 livers undergoing NMP and transplantation; 15/77 (19.5%) were DCD organs. The median donor age was 61 (15-87) years, median recipient age was 60 (19-73) years. Median (IQR) cold ischemia time was 6.2 (2.1) hrs, NMP-time and overall preservation time were 17.6 (10.4) hrs and 23.6 (10.6) hrs. Median (IQR) IL-6 levels (ng/L) after 1, 6 hrs and NMP-end were 52 (175), 278 (674) and 174 (2171). Neither duration of CIT nor NMP correlated with IL-6 levels over time. NMP-livers were stratified for the median of the last IL-6 measurement. Recipients receiving NMP-livers with perfusate IL-6 levels above the median developed significantly lower post-reperfusion MAP (dropping 20% from baseline) and displayed a significant higher demand of catecholamines (increase of 25% from baseline) up to 30 minutes after reperfusion (figure 1A-B). Perfusate IL-6 did not correlate with the occurrence of early allograft dysfunction.

*Conclusions: Perfusate IL-6 levels during liver NMP are clinically relevant as they may help to predict the post-reperfusion hemodynamics in recipients.

To cite this abstract in AMA style:

Weissenbacher A, Mathis S, Cardini B, Bogensperger C, Putzer G, Gasteiger L, Resch T, Oberhuber R, Öfner D, Hell T, Martini J, Schneeberger S. Perfusate Il-6 Levels During Liver Nmp Are Predictive For Hemodynamic Response And Catecholamine Demand After Reperfusion In The Recipient [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/perfusate-il-6-levels-during-liver-nmp-are-predictive-for-hemodynamic-response-and-catecholamine-demand-after-reperfusion-in-the-recipient/. Accessed December 3, 2024.

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