Pancreas Retransplantation: Outcomes of This Technical and Immunological Challenge over 38 Patients
1Urology and Transplantation, CHU Nantes, Nantes, France
2Nephrology and Transplantation, CHU Nantes, Nantes, France.
Meeting: 2018 American Transplant Congress
Abstract number: A345
Keywords: Efficacy, Pancreas transplantation, Retransplantation, Survival
Session Information
Session Name: Poster Session A: Pancreas and Islet: All Topics
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Introduction
Pancreas transplantation is now a mastered technique for patients suffering from severe diabetes. However, a significant number of grafts are lost for technical and immunological reasons.
Pancreas retransplantation is can be option in selected patients, but remains a high risk intervention. The goal of this study was to review our experience in pancreas retransplantation, to explore its surgical and immunologic outcomes.
Methods
All pancreas retransplantation that occured between 1996 and 2017 in Nantes were included. Graft survival and causes of graft loss were evaluated, as well as patients survival.
Results
From january 1987 to feburary 2017, 38 pancreas retransplantations were performed by the urologic surgeons in the CHU of Nantes. There was 9 female and 29 male, with a mean age of 42 years.
Graft survival was 64.5% at 5 years, 44.8% at 10 years. 11 patients (28,9%) lost their second pancreas, 3 from veinous thrombosis, 2 from chronic rejection.
Patients survival was 85.2% at 5 years, 74% at 10 years. Only one death was pancreas related (gas gangrene).
As for the kidney transplant, 5 patients had to go back on dialysis (4 for chronic kidney rejection, one after immunosuppressors arrest).
Discussion
A second pancreas transplantation is an acceptable option for diabetic patients that lost their first graft, with a good graft survival and a few impact on the kidney transplant.
CITATION INFORMATION: Paret F., Cantarovich D., Karam G., Batard T., Nedelec M., Branchereau J. Pancreas Retransplantation: Outcomes of This Technical and Immunological Challenge over 38 Patients Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Paret F, Cantarovich D, Karam G, Batard T, Nedelec M, Branchereau J. Pancreas Retransplantation: Outcomes of This Technical and Immunological Challenge over 38 Patients [abstract]. https://atcmeetingabstracts.com/abstract/pancreas-retransplantation-outcomes-of-this-technical-and-immunological-challenge-over-38-patients/. Accessed October 15, 2024.« Back to 2018 American Transplant Congress