Abstracts Archive - Page 814 of 1683 - ATC Abstracts

2018 American Transplant Congress
High Fibre Diet Induces Donor Specific Kidney Allograft Tolerance in Mice
H. Wu,^1,2 T. Kwan,² Y. Loh,² C. Wang,² L. Macia,² S. Alexander,^2,3 S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³The Children Hospital at Westmead, Sydney, Australia.
Aim: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid sodium acetate (SA) on kidney allograft…
2018 American Transplant Congress
Human CD8⁺CD28^– T Cells Driven In Vitro by IL-15 Suppress in Allo-Specific Manner Partially through PD-1:PD-L1 Pathway
F. Feng,^1,2 G. Liu,¹ P. Zhu,¹ M. Zhu,¹ X. Lu,¹ J. Liu,² X. Luo,³ Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; ³Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Background: CD8+CD28- T suppressor cells (Ts) have emerged as an important modulator of alloimmunity, but the in vitro inducibility of Ts subsets is rather unclear.…
2018 American Transplant Congress
Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.
G. Furtmüller,¹ B. Oh,¹ J. Sidhom,² M. Fryer,¹ V. Malek,¹ X. Zhou,¹ D. Cooney,¹ C. Brayton,³ J. Dodd-o,⁴ S. Ganguly,² G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD; ³Department for Comparative Pathobiology, Johns Hopkins University, Baltimore, MD; ⁴Department of Anesthesiology, Johns Hopkins University, Baltimore, MD.
Background: Treatment with PT/Cy in the setting of combined donor bone marrow transplantation and VCA has shown encouraging results with regards to chimerism induction and…
2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73^HIFR4^HIPD1⁺ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
A. Dangi,¹ L. Zhang,¹ X. Zhang,² X. Luo.^1,2
¹Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
2018 American Transplant Congress
TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival
L. Wang, A. Samanta, R. Han, N. Zhou, W. Hancock.
Path & Lab Med, CHOP & UPenn, Philadelphia, PA.
Given the major roadblocks to development of Treg-based cell therapy, pharmacologic approaches to expand endogenous Tregs warrant attention, including approaches with more sustained effects than…
2018 American Transplant Congress
T Cell Immunomonitoring Including Donor Specific Treg Expansion Prospectively Predicts Renal Allograft Tolerance Induced by Transient Mixed Chimerism
K. Hotta, T. Oura, A. Dehnadi, K. Huh, M. Matsunami, H. Sasaki, G. Benichou, J. Madsen, A. Cosimi, T. Kawai.
Center for Transplant Science, Massachusetts General Hospital, Boston, MA.
Background: Successful induction of allograft tolerance in MHC-mismatched kidney transplantation has been achieved after induction of transient chimerism in both nonhuman primates (NHP) and humans.…
2018 American Transplant Congress
Immunomodulation of Alloantibody Responses
C. Schuetz, M. Climov, A. Paril, Z. Wang, A. Andrews Roy, N. Navarro Alvarez, A. Matar, D. Sachs, R. Duran-Struuck, C. Huang.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
We have shown that i.v. exposure to MHC-mismatched donor PBMC using a novel, mild conditioning protocol results in B-cell tolerance with transient T-cell unresponsiveness. Here…
2018 American Transplant Congress
M-CSF and TNF-α Induce Human MDSCs That Attenuate GVHD
F. Han, C. Ding, Y. Zhao, P. Tian.
Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Myeloid-derived suppressor cells (MDSCs) negatively regulate immune response and participate in the induction of prolonged allograft survival in animal models. Human MDSC therapy may be…
2018 American Transplant Congress
The Role of pDCs in Formation of Treg-Rich Organized Lymphoid Structures in Spontaneously Accepted Murine Kidney Allografts is Dependent on Mismatching of MHC Class II Molecules at the H2-I-A^b Locus
T. O'Shea,^1,2 C. Yang,¹ I. Rosales,² N. Oh,¹ D. Ndishibandi,^1,2 T. Ashry,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction: Our lab has demonstrated that murine kidney allografts are spontaneously accepted in specific donor-recipient strain combinations. Histologic examination of spontaneously accepted DBA/2J (DBA) kidneys…
2018 American Transplant Congress
Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection
N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…