Abstracts Archive - Page 785 of 1683 - ATC Abstracts

2018 American Transplant Congress
Biopsy Correlates of DSA in Antibody-Mediated Rejection: C4d vs Microvascular Inflammation Scores
C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.
Icahn School of Medicine at Mount Sinai, New York, NY.
Background: The diagnosis of antibody-mediated rejection (AMR) requires the presence of both the histologic features of AMR as well as donor-specific antibodies (DSA). Whether anti-HLA…
2018 American Transplant Congress
The Treatment of Antibody-Mediated Rejection in Kidney Transplantation: An Updated Systematic Review and Meta-Analysis
S. Wan,^1,2 T. Ying,^1,2 K. Wyburn,^1,2 D. Roberts,^3,4 M. Wyld,^1,2 S. Chadban.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia; ³Department of Renal Medicine, Canberra Hospital and Health Services, Canberra, Australia; ⁴Medical School, Australian National University, Canberra, Australia.
Introduction: Current treatment strategies for antibody-mediated rejection (AMR) in kidney transplantation are based on low quality data from a small number of controlled trials. Novel…
2018 American Transplant Congress
Impact of De Novo DSA (DnDSA) on Outcomes in HLA-Sensitized (HS) Patients Transplanted after IVIG + Rituximab Desensitization (DES)
A. Vo,¹ O. Aubert,² H. Edmund,¹ A. Peng,¹ R. Najjar,¹ S. Supreet,¹ J. Choi,¹ K. Lim,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France.
Introduction: Highly-HLA sensitized patients (HS) with donor specific antibodies (DSA) at transplant are at risk for Type 1 ABMR. However, the incidence of Type 2…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
The Promising Approach in Difficult Atypical Hemolytic Uremic Syndrome Series in Renal Transplantation
B. Yelken,¹ S. Gorcin,¹ E. Demir,² C. Karatas,³ E. Arpali,⁴ B. Akyollu,³ B. Kocak,⁴ O. Elbasi,⁵ E. Eksioğlu,⁵ A. Turkmen.²
¹Nephrology, Sisli Memorial Hospital, Istanbul, Turkey; ²Nephrology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey; ³General Surgery, Sisli Memorial Hospital, Istanbul, Turkey; ⁴Urology, Sisli Memorial Hospital, Istanbul, Turkey; ⁵Immunology, Sisli Memorial Hospital, Istanbul, Turkey.
BACKGROUND:Atypical hemolytic-uremic syndrome (aHUS) belongs to the group of thrombotic microangiopathies (TMAs), which can recur after renal transplantation if they have been identified as the…
2018 American Transplant Congress
Comparison of C1Q Binding and Flow Cytometric Crossmatch Results Provides an Accurate Evaluation of Hypersensitive Kidney Transplant Patients
E. Eksioğlu-Demiralp,¹ A. Türkmen,² B. Yelken,² S. Görçin,² O. Elbasi,¹ F. Yalçin,³ B. Koçak,² C. Karatas,⁴ M. Tuncer,⁴ M. Altinel.³
¹Tissue Typing and Immunology Laboratory, Memorial Health Group, Istanbul, Turkey; ²Sisli Hospital Transplantation Unit, Memorial Health Group, Istanbul, Turkey; ³Hizmet Hospital Transplantation Unit, Memorial Health Group, Istanbul, Turkey; ⁴Atasehir Hospital Transplantation Unit, Memorial Health Group, Istanbul, Turkey.
Measurement of C1q binding to Donor specific antibodies (DSA) gives transplantation chance to hypersensitive patients having non-binding high amount of anti-HLA antibodies. In our series…
2018 American Transplant Congress
Impact of Pretransplant Donor-Specific Antibodies on Kidney Allograft Recipients with Negative Flow Cytometry Crossmatches
H. Kwon, Y. Kim, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.
Asan Medical Center, Seoul, Korea.
This study evaluated the impact of DSA on clinical outcomes in KT recipients negative on FCXM. Of 575 consecutive patients who underwent living donor KT…
2018 American Transplant Congress
Is the NETos Increased in Acute Antibody Mediated Rejection?
R. Villca-Gonzales,¹ J. Torres-Ruiz,² D. Gomez-Martin,² J. Alberu,³ L. Morales-Buenrostro.¹
¹Nephrology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; ²Immunology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; ³Transplantation, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico.
Neutrophils can promote graft inflammation through a form of programmed cell death termed "NETosis". How alloantibodies contribute to neutrophil responses in grafts is not clear…
2018 American Transplant Congress
Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients
C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.
Icahn School of Medicine at Mount Sinai, New York.
Background: Studies have shown that borderline rejection (BR) and acute cellular rejection (ACR) often co-occur with antibody-mediated rejection (AMR). We examined the association between interstitial…
2018 American Transplant Congress
Clinical Heterogeneity of Early Anamnestic Donor Specific Antibody Responses in Kidney Transplantation
A. Loethen,¹ A. Lichvar,¹ S. Tremblay,¹ A. Shields,^1,2 A. Dao,¹ M. Cardi,² P. Brailey,¹ A. Girnita,¹ B. Abu Jawdeh,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati, OH; ²Christ Hospital, Cincinnati, OH.
Anamnestic donor specific antibody(DSA) responses in the early post-transplant period may threaten the renal transplant(RTx). We hypothesize earlier DSA detection will allow minimization of RTx…