Abstracts Archive - Page 572 of 1683 - ATC Abstracts

2019 American Transplant Congress
High Prevalence of De Novo Donor-Specific Antibodies during Rejection after Liver Transplantation
J. Colmenero, N. Flores, A. Diaz, M. Vasquez, P. Ruiz, G. Crespo, J. Martorell, M. Navasa
Liver Transplant Unit, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Anti-HLA donor specific antibodies (dnDSA) after liver transplantation (LT) are currently under investigation. Recent studies show an incidence of dnDSA after LT ranging from…
2019 American Transplant Congress
Nivolumab-Induced Rejection of a Liver Allograft: PD-1 Inhibition Thwarts Liver Allograft Resistance to Humoral Rejection
B. T. Lee, H. Han, S. Chopra, A. J. Ahearn
Surgery, USC Keck School of Medicine, Los Angeles, CA
*Purpose: Checkpoint inhibitor therapy with Programmed cell death protein (PD-1) inhibitors has recently been FDA approved for the treatment of several malignancies. However, it has…
2019 American Transplant Congress
Immunologic Impact Of Native Kidney Function On Liver Transplant Patients
M. Mujtaba, S. Merwat, J. Fair, M. Bilal, A. Chatila, R. Kulkarni, J. Zou, S. Hussain, A. Gamilla-Crudo
Univ. of Texas Medical Branch, Galveston, TX
*Purpose: Renal failure in the setting of liver transplantation (LTx) is common and has an adverse impact on short and long-term graft and patient survival.…
2019 American Transplant Congress
Fatal Graft versus Host Disease in Liver Transplantation. An Analysis of UNOS Registry
S. Nagai¹, A. Yoshida¹, R. Salgia², M. Abouljoud¹, D. Moonka²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Graft-versus-host disease (GVHD) after liver transplant is a rare complication. This study aimed to analyze the UNOS registry to identify risk factors for fatal…
2019 American Transplant Congress
Assessing the Effectiveness of Early Maintenance Immunosuppression Practices in Liver Transplantation
T. Bittermann, R. Hubbard, J. Lewis, D. Goldberg
University of Pennsylvania, Philadelphia, PA
*Purpose: Evidence regarding the efficacy of maintenance immunosuppression (IS) regimens for liver transplantation (LT) arise from clinical trials. However, the ‘real world’ effectiveness of such…
2019 American Transplant Congress
Natural Course Of Tacrolimus Intra-patient Variability In Liver Transplant Recipients
N. Wilson, S. Tremblay, N. S. Ejaz, K. Zheng, J. Garrett, S. A. Shah, R. R. Alloway, T. E. Kaiser
University of Cincinnati, Cincinnati, OH
*Purpose: The evolution of tacrolimus (TAC) intra-patient variability (IPV) post liver transplant (LT) remains to be characterized. Identification of factors associated with high TAC-IPV may…
2019 American Transplant Congress
Karnofsky Performance Score as a Predictor of Acute Cellular Rejection Post Liver Transplantation
N. Kapila¹, K. Al Khalloufi², F. Salomon³, K. Kapila⁴, A. Gupta³, X. B. Zervos²
¹Gastroenterology and Hepatology, Cleveland Clinic Florida, Weston, FL, ²Transplant, Cleveland Clinic Florida, Weston, FL, ³Internal Medicine, Cleveland Clinic Florida, Weston, FL, ⁴Internal Medicine, University of Miami/JFK Medical Center, Atlantis, FL
*Purpose: The incidence of acute cellular rejection (ACR) following liver transplantation (LT) ranges from 20-40%. Development of ACR is associated with increased risk of graft…
2019 American Transplant Congress
Discovery and Validation of Blood Genomic Signatures of Acute Rejection in Liver Transplant Recipients
J. Levitsky¹, N. Bridges², J. Odim², M. Brown², D. Ikle³, B. Armstrong³, A. Demetris⁴, S. Asrani⁵, G. Klintmalm⁵, T. Schiano⁶, A. Moss⁷, K. Chavin⁸, C. Miller⁹, M. Kandpal¹⁰, L. Zhao¹⁰, S. Kurian¹¹, M. Abecassis¹⁰
¹Div of Gastroenterology & Comprehensive Tx Cnt, Chicago, IL, ²NIAID, Bethesda, MD, ³Rho, Chapel Hill, NC, ⁴UPMC, Pittsburgh, PA, ⁵Baylor, Dallas, TX, ⁶Mount Sinai, New York, NY, ⁷Mayo Arizona, Phoenix, AZ, ⁸Case Western, Cleveland, OH, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Comprehensive Transplant Center, Chicago, IL, ¹¹Scripps, San Diego, CA
*Purpose: Biomarker profiles diagnostic of acute rejection (AR) could enhance the management of liver transplant (LT) recipients. Our aim was to discover and validate blood…
2019 American Transplant Congress
Induction Immunosuppression Practices in Liver Transplantation are Variable and Predict Post-Transplant Survival
T. Bittermann¹, R. Hubbard², J. Lewis¹, D. Goldberg¹
¹Gastroenterology, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Unlike in other solid organ transplants, the benefits of induction immunosuppression prior to liver transplantation (LT) remain uncertain. The objective of this study was…
2019 American Transplant Congress
Leukopenia at the Time of Liver Transplantation: Medication Tolerance and Clinical Outcomes
E. Tiao¹, J. Casale¹, J. LaMattina², S. Hammad¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Surgery, University of Maryland School of Medicine, Baltimore, MD
*Purpose: Leukopenia post-orthotopic liver transplant (OLT) is associated with an increased incidence of infection and mortality. Prior to OLT, leukopenia may suggest innate immunosuppression and…