Abstracts Archive - Page 547 of 1683 - ATC Abstracts

2020 American Transplant Congress
The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor C-MET Signaling
L. Paka, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: Hepatocyte growth factor (HGF) regulates cell growth, development and tissue repair. HGF activity is mediated by the c-MET signaling pathway. The biological effects of…
2020 American Transplant Congress
Hematopoietic Cell Kinase Promotes Kidney Fibrosis Through Autophagy Pathway
C. Wei, L. Mou, K. Banu, M. Menon, W. Zhang, C. He, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In our previous studies, we identified hematopoietic cell kinase (HCK) as a key driver of renal fibrosis through TGFβ/Smad3 pathway. Here in this study,…
2020 American Transplant Congress
Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection
S. Li¹, M. Song¹, Q. Li², A. Kirk¹, H. Xu¹
¹Surgery, Duke University, Durham, NC, ²Immunology, Duke University, Durham, NC
*Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…
2020 American Transplant Congress
Age-Enhanced Transplant Vasculopathy Associates with Impaired Vascular Mitophagy
M. Blin¹, D. Tyrrell¹, S. Wood¹, D. Farris¹, S. G. Tullius², D. R. Goldstein¹
¹Micro and Immunology/Internal Medicine, University of Michigan, Ann Arbor, MI, ²Transplant Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor aging leads to increased chronic allograft vasculopathy (CAV) for unclear reasons. Here, we investigated whether impaired alterations in mitophagy, a mechanism to remove…
2020 American Transplant Congress
Endothelial Cells Internalize Apoptotic Exosome-Like Vesicles Through Phosphatidylserine-Dependent Macropinocytosis
F. Migneault, M. Dieudé, A. Brodeur, N. Thibodeau, D. Beillevaire, M. Hébert
CRCHUM, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion and rejection favor endothelial apoptosis, which in turn contributes to maladaptive vascular repair leading to transplant vasculopathy. Apoptotic endothelial cells (EC) release exosome-like…
2020 American Transplant Congress
Clinical Outcomes from a Mobile Health, Pharmacist-Led Intervention: 12-Month Results of the Transafe Rx Randomized Controlled Trial
D. Taber, J. Hirsch, Z. Su, J. McGillicuddy, A. Posadas, J. Fleming
Med Univ of South Carolina, Charleston, SC
*Purpose: Medication errors and non-adherence are predominant causes of poor graft outcomes in kidney transplant (KTX) recipients. The primary aim of the TRANSAFE Rx RCT…
2020 American Transplant Congress
Highly Effective Short Course Therapy to Prevent Infection after Transplantation from HCV-Infected Organ Donors to Uninfected Recipients across Multiple Organ Types
A. Humar¹, M. Cypel¹, D. Kumar¹, H. Dahari², R. Vanin Pinto Ribeiro¹, N. Marks¹, N. Kamkar¹, I. Bahinskaya¹, F. Onofrio³, M. A. Zahoor³, O. Cerrochi³, K. Tinckam¹, S. J. Kim¹, T. W. Reichman¹, M. McDonald¹, T. K. Waddell¹, G. Sapisochin¹, M. Selzner¹, S. Keshavjee¹, H. L. Janssen³, B. E. Hansen³, L. Singer¹, J. Feld³
¹Transplant Centre, Toronto General Hospital, Toronto, ON, Canada, ²Loyala University, Chicago, IL, ³Toronto General Hospital, Toronto, ON, Canada
*Purpose: An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). Establishment of HCV infection in uninfected recipients is near-universal with…
2020 American Transplant Congress
Impact of Extended- versus Immediate-Release Tacrolimus on One-Year Development of De Novo DSA and Chronic Immune Activation in Kidney Transplantation (ASTOUND Study)
A. Wiseman¹, D. Kaufman², A. Patel³, D. Wojciechowski⁴, A. Tambur⁵, J. Kim⁶, J. Schwartz⁶
¹University of Colorado Hospital, Aurora, CO, ²University of Wisconsin, Madison, WI, ³Henry Ford Hospital, Detroit, MS, ⁴Massachusetts General Hospital, Boston, MA, ⁵Northwestern University, Chicago, IL, ⁶Astellas Pharma Global Development, Northbrook, IL
*Purpose: To compare, using an adaptive study design, the 1-year incidence of a novel two-part composite endpoint consisting of de novo donor-specific antibody (dnDSA) formation…
2020 American Transplant Congress
End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial
P. Husen¹, C. Boffa², I. Jochmans³, C. Krikke⁴, L. Davies², H. Hofker⁴, J. Pirenne³, R. Ploeg², A. Paul¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³University Hospitals Leuven, Leuven, Belgium, ⁴University Medical Center Groningen, Groningen, Netherlands
*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term 'in house' oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus…
2020 American Transplant Congress
Feasibility and Long Term Safety of T Regulatory Cell Therapy in Kidney Transplantation
P. N. Harden¹, D. Game², J. Van der Net¹, F. Issa³, W. Petchey¹, M. Brook¹, P. Friend¹, R. Hilton⁴, G. Lombardi⁵, K. Wood³
¹Kidney Transplantation, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, ²Kidney Transplantation, Guys and St Thomas's Hospital, London, United Kingdom, ³Transplant Immunology Research Group, Oxford University, Oxford, United Kingdom, ⁴Kidney Transplantation, Guys and St Thomas's Hospital, Oxford, United Kingdom, ⁵Transplant Immunology Group, Kings Healthcare Partners, London, United Kingdom
*Purpose: A sequential clinical trial of autologous polyclonal T regulatory cellular therapy compared with a standardised reference cohort of live donor kidney transplant recipients. The…