Abstracts Archive - Page 382 of 1683 - ATC Abstracts

2020 American Transplant Congress
The Fibrinogen-Like Protein 2 Molecule Influences the Development of Thymic Regulatory T-Cells
C. Lam¹, S. Moshkelgosha¹, G. A. Levy², A. Chruscinski³, S. C. Juvet⁴
¹Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada, ²Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada, ³Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, Canada, ⁴Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
*Purpose: Transplantation is the primary treatment for patients with end-stage organ failure. However, long-term outcomes are limited by immunosuppressant toxicities and chronic graft rejection. Identifying…
2020 American Transplant Congress
ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation
B. Motyka¹, A. Halpin¹, J. Pearcey¹, A. Kariminia², A. Halevy², S. Maier¹, A. Halevy², P. Subrt², C. W. Cairo¹, G. D. Cuvelier³, K. R. Schultz², L. J. West¹
¹Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, ²British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, ³CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
*Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO.…
2020 American Transplant Congress
A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data
J. Vetter¹, A. Heinzel², C. Aschauer², R. Reindl-Schwaighofer², K. Jelencsics², K. Hu², R. Oberbauer², S. Winkler¹, S. Schaller¹
¹Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, ²Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
*Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…
2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Y. Itabashi, R. Ravichandran, S. Bansal, T. Fleming, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…
2020 American Transplant Congress
Post-Transplantation Lymph Node Fibrosis: Significant Implications in Transplant Tolerance
X. Li¹, J. Zhao¹, L. Jiang¹, M. Uehara¹, V. Kasinath¹, S. Shin¹, S. G. Tullius¹, J. S. Bromberg², R. Abdi¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Maryland School of Medicine, Boston, MA
*Purpose: Lymph nodes (LNs) have been regarded as primary activation sites for alloimmunity following transplantation, but our group has revealed an additional dimension to their…
2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
K. Kumano¹, M. A. Kanak², S. Vasu¹, Y. Liu¹, M. Lawrence¹, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Virginial Commonwealth University Medical Center, Richmond, VA
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…
2020 American Transplant Congress
Prevalence of Risk Factors for NAFLD among Living Liver Donors
D. A. Axelrod¹, M. Simpson², E. Pomfret³, A. Ehrlich⁴, S. Rwema⁴, R. Chung⁴, F. Gordon⁵
¹Surgery, University of Iowa, Iowa CIty, IA, ²Surgery, Lahey Clinic, Burlington, MA, ³University of Colorado, Denver, CA, ⁴Mass General Hospital, Boston, MA, ⁵Lahey, Burlington, MA
*Purpose: The development of non-alcoholic fatty liver (NAFLD) disease has been strongly associated with the presence of polymorphisms in PNPLA3 rs738409. When compared with wild…
2020 American Transplant Congress
The Effect of Expanding Utilization of Living Donor Liver Transplantation tn the United States
K. N. Wanis¹, A. Sarvet¹, M. J. Stensrud¹, B. Al-Judaibi², K. Tomiyama³, R. Hernandez-Alejandro³
¹Epidemiology, Harvard School of Public Health, Boston, MA, ²Division of Transplantation, University of Rochester, Rochester, NY, ³Division of Transplantation/Hepatobiliary Surgery, Department of Surgery, University of Rochester, Rochester, NY
*Purpose: We estimated the effect that expansion of living donor liver transplantation (LDLT) would have on mortality for individuals added to the waitlist.*Methods: Using data…
2020 American Transplant Congress
Efficacy of Generic Sofosbuvir and Branded Daclatasvir Compared to Sofosbuvir and Ledipasvir Combination in the Treatment of Genotype 4 Hepatitis C Virus
H. Joharji, D. Alkortas, A. Ajlan, E. Devol, M. Ahmed, F. Aba Al-Khail, H. Elsiesy, M. Alsebayel, H. Alashgar, M. Alquaiz, W. Alhamoudi, A. Almoshishir, A. Aljedai
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
*Purpose: Genotype 4 HCV is the most common genotype in Saudi Arabia and the Middle East. Management of HCV has shifted in the last few…
2020 American Transplant Congress
Incidence of Non-Tuberculous Mycobacteria in the Transplant Population at a University Transplant Center in Northern Florida
D. Schain, Z. Breslow, G. El Helou, A. Cannella
Medicine/IDGM, Univ of Florida, College of Med, Gainesville, FL
*Purpose: Over the past decade, there has been an increase in the number of non-tuberculous mycobacteria (NTM) infections in the United States, especially in the…