Abstracts Archive - Page 382 of 1683 - ATC Abstracts

2020 American Transplant Congress
Intra-Lymph Node Injection of Microparticles Reprograms the Laminin Stromal Network to Prolong Allograft Survival
C. M. Paluskievicz¹, Y. Xiong¹, W. Piao¹, M. Willson-Shirkey¹, H. Eppler², C. M. Jewell², J. S. Bromberg¹
¹U Maryland, Baltimore, MD, Baltimore, MD, ²U Maryland, College Park, MD, College Park, MD
*Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) to induce pro-inflammatory or anti-inflammatory responses. We hypothesized…
2020 American Transplant Congress
A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data
J. Vetter¹, A. Heinzel², C. Aschauer², R. Reindl-Schwaighofer², K. Jelencsics², K. Hu², R. Oberbauer², S. Winkler¹, S. Schaller¹
¹Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, ²Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
*Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…
2020 American Transplant Congress
Single Cell RNA Sequencing Analysis of 3 Human Living-Donor Liver Transplant Allograft Biopsies after Infusion of Donor-Derived Regulatory Dendritic Cells
L. M. Tran¹, T. Tabib², A. F. Zahorchak¹, R. Lafyatis², M. A. Styn¹, A. Humar¹, F. G. Lakkis¹, D. M. Metes¹, A. W. Thomson¹
¹Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Department of Medicine and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Single-cell RNA sequencing is an emerging, powerful genomic technology that can describe heterogenous cellular populations of whole solid organs with high resolution. We report…
2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Y. Itabashi, R. Ravichandran, S. Bansal, T. Fleming, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…
2020 American Transplant Congress
Robot-Assisted versus Open Kidney Transplantation for Morbidly Obese Patients
S. D. Lee¹, B. Rawashdeh², E. K. McCracken², L. A. Cantrell³, A. Demirag², A. Agarwal², K. L. Brayman², S. J. Pelletier², J. Oberholzer²
¹Surgery, VCU Health, Richmond, VA, ²Surgery, University of Virginia, Charlottesville, VA, ³Obstetrics and Gynecology, University of Virginia, Charlottesville, VA
*Purpose: Obesity significantly impacts intraoperative and postoperative complications following kidney transplantation. Consequently, many centers deny access to transplantation in patients with a body mass index…
2020 American Transplant Congress
Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation
C. Aschauer¹, K. Jelencsics¹, K. Hu¹, R. Reindl-Schwaighofer¹, J. Vetter², A. Heinzel¹, A. Kainz¹, G. Gualdoni¹, S. Schaller², S. Winkler², R. Oberbauer¹
¹Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, ²Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg im Muehlkreis, Austria
*Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…
2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
K. Kumano¹, M. A. Kanak², S. Vasu¹, Y. Liu¹, M. Lawrence¹, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Virginial Commonwealth University Medical Center, Richmond, VA
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…
2020 American Transplant Congress
Exploring Psychosocial Factors and Disparity in Liver Transplant
K. Schmidt
Dept. of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA
*Purpose: Trends in liver transplant (LT) have shifted, and increasingly, individuals with alcohol liver disease (ALD) are receiving LT without 6-months of sobriety (Lee &…
2020 American Transplant Congress
The Effect of Expanding Utilization of Living Donor Liver Transplantation tn the United States
K. N. Wanis¹, A. Sarvet¹, M. J. Stensrud¹, B. Al-Judaibi², K. Tomiyama³, R. Hernandez-Alejandro³
¹Epidemiology, Harvard School of Public Health, Boston, MA, ²Division of Transplantation, University of Rochester, Rochester, NY, ³Division of Transplantation/Hepatobiliary Surgery, Department of Surgery, University of Rochester, Rochester, NY
*Purpose: We estimated the effect that expansion of living donor liver transplantation (LDLT) would have on mortality for individuals added to the waitlist.*Methods: Using data…
2020 American Transplant Congress
The Challenge of Selecting an Induction Agent: A Dual Regimen for Medically High-Risk Kidney Recipients
R. Craig-Schapiro, B. Magaoay, R. Grover, S. Sultan, M. Aull, S. Kapur
Weill Cornell Medical Center, New York, NY
*Purpose: Complications of the commonly used lymphocyte-depleting induction agent, rabbit anti-thymocyte globulin (rATG),include cardiorespiratory dysfunction with hypotension, tachycardia, myocardial infarction, and pulmonary edema. The choice…