Abstracts Archive - Page 327 of 1683 - ATC Abstracts

2021 American Transplant Congress
AlloMap Kidney Gene Expression Profiling Discriminates Rejection from Immuno-Quiescence in Renal Transplant Recipients
E. Akalin¹, A. Djamali², H. Xu³, X. Jin³, R. N. Woodward³, S. Dholakia³, J. S. Bromberg⁴
¹Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, ²University of Wisconsin, Madison, WI, ³CareDx, Brisbane, CA, ⁴University of Maryland School of Medicine, Baltimore, MD
*Purpose: Assessment of immune activation is important when considering pathologies such as allograft rejection as well as potential interventions that may extend allograft survival. Optimizing…
2021 American Transplant Congress
Evaluation of Serum Klotho Levels at Early Kidney Post-Transplant
T. Vazquez-Sanchez¹, J. Alonso-Titos¹, M. Sánchez-Niño², E. Sola¹, M. Leon³, V. Lopez¹, P. Ruiz-Esteban¹, E. Porrini⁴, A. Ortiz⁵, D. Hernández¹
¹Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Malaga, Spain, ²Nephrology, Instituto de InvestigaciónSanitaria de la FundaciónJiménez Díaz,UniversidadAutónoma de Madrid. REDINREN, Madrid, Spain, ³Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Malaga, Spain, ⁴Nephrology, Hospital Universitario de Canarias, CIBICAN, Universidadde laLaguna, REDinREN (RD16/0009/0031) Tenerife e Instituto Reina Sofía de Investigación Renal (IRSIN), Malaga, Spain, ⁵Nephrology, Instituto de InvestigaciónSanitaria de la FundaciónJiménez Díaz,UniversidadAutónoma de Madrid. REDINREN, Malaga, Spain
*Purpose: Klotho expression is lowered in patients with chronic kidney disease (CKD). After kidney transplant (KT), serum Klotho levels could be significantly increased compared to…
2021 American Transplant Congress
Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring
K. R. Sherwood¹, P. Wong¹, F. Fenninger¹, V. Wu¹, J. Beckrud², D. P. Cina³, L. Allan², J. Lan², P. A. Keown²
¹University of British Columbia, Vancouver, BC, Canada, ²Vancouver General Hospital, Vancouver, BC, Canada, ³Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada
*Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
2021 American Transplant Congress
Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis
H. BAE¹, H. Lee², J. Ryu³, B. Chung², E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of
*Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
2021 American Transplant Congress
Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation
L. M. Radomsky¹, A. Koch², C. Olbertz², J. F. Kuehne¹, Y. Liu², J. Keil¹, K. Beushausen¹, U. Rauen³, C. S. Falk¹, M. Kamler²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany
*Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
2021 American Transplant Congress
Is Subclinical Allograft Rejection by 2019 Banff Criteria Associated with Worse Kidney Allograft Outcomes? Comparison Between 2007 and 2019 Banff Criteria
M. T. Victor¹, S. Park², K. Guo¹, L. Zhao¹, J. Friedewald³
¹Feinberg School of Medicine, Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern Univeristy, Chicago, IL, ³Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: We hypothesize that Subclinical Acute Rejection (SubAR) under the new Banff 2019 criteria will be more strongly associated with a 2-year composite endpoint (2Y-CCE)…
2021 American Transplant Congress
Belatacept for Kidney Transplantation in the Age of Covid19, is it Safe?
J. Pagan¹, S. Anjan², Y. Natori³, A. Fernandez³, R. Zamora-Gonzalez², A. Mattiazzi¹, L. Mendez¹, G. Guerra¹
¹Nephrology, University of Miami, Miami, FL, ²Infectious Diseases, University of Miami, Miami, FL, ³Infectious Disease, University of Miami, Miami, FL
*Purpose: The COVID19 pandemic has affected kidney transplant recipients (KTR) with a wide spectrum of clinical severity. Up to this point, we have solely seen…
2021 American Transplant Congress
A Psychosocial Clinician Rating Scale is Used Differently Across Solid Organ Teams within a Single Transplant Center
S. Entenman¹, T. Chaffee², M. Pienta³, B. Young³, E. Clifton¹, J. Mellinger⁴, L. McElroy⁵, G. Winder¹
¹Psychiatry, University of Michigan, Ann Arbor, MI, ²Psychiatry, University of Missouri-Kansas City, Kansas City, MO, ³Surgery, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Surgery, Duke University, Durham, NC
*Purpose: Transplant psychosocial clinician rating scales like the Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) are widely used tools to standardize subjective patient data, stratify…
2021 American Transplant Congress
Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation
K. Lee, J. Park
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…
2021 American Transplant Congress
Posttraumatic Stress and Medication Adherence in Pediatric Transplant Recipients
S. Duncan-Park¹, L. Danziger-Isakov², B. Armstrong³, N. Williams⁴, J. Odim⁴, E. Shemesh⁵, S. Sweet⁶, R. Annunziato¹
¹Icahn School of Medicine at Mount Sinai and Fordham University, New York, NY, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rho Inc., Durham, NC, ⁴NIAID, Bethesda, MD, ⁵Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Washington University in St. Louis, St. Louis, MO
*Purpose: We investigated the relationship between posttraumatic stress symptoms (PTSS), medication adherence, and quality of life (QoL) in adolescent transplant recipients.*Methods: This protocol of the…