Abstracts Archive - Page 325 of 1683 - ATC Abstracts

2021 American Transplant Congress
Brain Natriuretic Peptide and Pedometer Activity are Most Predictive of Poor Kidney Transplant Waitlist Outcomes
P. Manay¹, P. TenEyck², R. Kalil³, M. Sanders⁴, M. Swee⁴, G. Binns⁵, J. Hornikel⁵, D. Katz¹
¹Department of Surgery, University of Iowa, Iowa City, IA, ²Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, ³Department of Medicine, University of Maryland Medical Center, Baltimore, MD, ⁴Department of Medicine, University of Iowa, Iowa City, IA, ⁵Iowa City VAMC, Iowa City, IA
*Purpose: Tools for indicating which patients are most at risk for complications and death after transplant listing would allow for a rational approach to targeted…
2021 American Transplant Congress
Incidence of Pancreatic Exocrine Insufficiency in Patients Undergoing Liver Transplantation
J. Klein¹, M. Rangel¹, I. Ifearulundu¹, Y. Gely¹, Z. Spigel², S. Janardhan³, M. Hertl¹, E. Chan¹
¹Surgery, Rush University Medical Center, Chicago, IL, ²Surgery, Allegheny Health Network, Pittsburgh, PA, ³Hepatology, Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study was to determine the incidence of Pancreatic Exocrine Insufficiency (PEI) in patients undergoing liver transplantation. Furthermore, patient-specific risk factors…
2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
J. Kang¹, L. Belyayev¹, O. Aguirre¹, K. Khan¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom³, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, ³Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…
2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
A. Johnson¹, G. Karadkhele², C. Larsen¹
¹Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…
2021 American Transplant Congress
Characteristics, Risk Factors, and Outcomes of Neutropenia for the First Year After Liver or Kidney Transplantation in Children
C. Jarasvaraparn¹, S. Choudhury², C. Rusch², K. Liss¹, J. Stoll¹, S. Hmiel³, S. Kulkarni¹
¹Pediatric Gastroenterology, Washington University School in St Louis, Saint Louis, MO, ²Pediatric, Washington University School in St Louis, Saint Louis, MO, ³Pediatric Nephrology, Washington University School in St Louis, Saint Louis, MO
*Purpose: Prior studies in adults have shown that approximately 20-38 % of subjects undergoing solid organ transplant develop neutropenia. In the current study, we characterized…
2021 American Transplant Congress
Comparative Proteomics Analysis Identifies the Biomarker of Ischemia-Reperfusion Injury During Liver Transplantation
M. Chen¹, L. Xiaohong², H. Xitao¹, J. Weiqiang¹
¹Transplant Center, Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: To a large extent the success of liver transplantation depends on quality of allografts. The molecular basis of the susceptibility of different liver allografts…
2021 American Transplant Congress
An Immune-modulatory Strategy to Mitigate Hepatic Ischemia/reperfusion Injury in a Murine Model
A. Kobayashi, A. Wanchoo, S. Farhadi, J. Simonovich, S. Duarte, V. Boominathan, S. Shrestha, G. Hudalla, B. G. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2021 American Transplant Congress
Kidney Programs Can Filter Off a Majority of Their Unwanted Organ Offers without Harming Transplant Volumes
A. Toll, H. McGehee, R. McTier, D. Stewart
Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Evaluate if multifactorial filters can reduce unwanted kidney offers to centers, thereby reducing administrative burden and getting to the accepting candidate quicker.*Methods: 34 centers…
2021 American Transplant Congress
Transgenic Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1, Or Hcd39) in Pig to Primate Xenotransplantation Models
R. Matheson¹, K. Deng¹, K. M. Lee¹, Z. A. Habibabady¹, C. G. Rickert¹, K. J. Ahrens¹, J. M. O¹, D. Becerra¹, P. Patel¹, W. Westlin², M. Youd², N. Serifis¹, T. M. Coe¹, D. Cloonan¹, A. M. Azimzadeh¹, C. LeGuern¹, J. C. Madsen¹, S. C. Robson³, J. F. Markmann¹
¹Transplantation Surgery Research, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Human CD39 (hCD39) is the gene of interest in xenotransplantation due to its reported capacity to prevent platelet aggregation by metabolizing extracellular ATP to…
2021 American Transplant Congress
Comparison of Donor-derived Cell Free Dna Between Recipients with First Solitary Allograft and Regrafts
S. Paluri¹, S. Muthusamy¹, M. Shinbashi¹, G. Gupta¹, B. Dale², Z. Kashi³, P. Halloran⁴, D. Kumar¹
¹Virginia Commonwealth University, Richmond, VA, ²CareDx, Brisbane, CA, ³Kashi Clinical Laboratories, Portland, OR, ⁴ATAGC, Edmonton, AB, Canada
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker of immunological injury. Multiple studies have validated its utility in recipients of first solitary kidney transplants…